protein

HSP27

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP27: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

2Analyses

50Outgoing

42Incoming

0Experiments

2Debates

Summary

HSP27 is a protein involved in neurodegeneration research. Key relationships include: regulates, treats, therapeutic target. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 83 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HSPB1
Full Name	Heat Shock Protein Family B Member 1
Aliases	Hsp27
Chromosome	7q11.23.
Molecular Weight	27 kDa
Amino Acids	205 aa
Pathways	MAPK Pathway, NF-κB, PI3K
GeneCards	HSPB1
Human Protein Atlas	HSPB1
Basal state	16-24 subunit oligomers
Stressed state	Smaller oligomers (8-12 mers) with increased chaperone activity
Phosphorylated state	Disassembly to dimers/tetramers
Associated Diseases	Aging, Als, Alzheimer, Cardiovascular, disease, Ms
Interactions	Actin, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
SciDEX Hypotheses	HSPB1 Phosphorylation Mimetics to Promote Protecti
KG Connections	321 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: HSP27 — AlphaFold P04792 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HSPB1 — Heat Shock Protein Family B Member 1

gene · 1404 words

→

Pathway Diagram

graph TD
    HSP27["HSP27"]
    Neurodegeneration{"Neurodegeneration"}
    HSP27 -->|"regulates"| Neurodegeneration
    Als{"Als"}
    HSP27 -->|"regulates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    HSP27 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    HSP27 -->|"regulates"| Ms
    HSP27 -->|"activates"| Als
    HSP27 -->|"activates"| Ms
    HSP27 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Cancer{"Cancer"}
    HSP27 -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    HSP27 -->|"regulates"| Tumor
    Parkinson{"Parkinson"}
    HSP27 -->|"therapeutic target"| Parkinson
    Fibrosis{"Fibrosis"}
    HSP27 -->|"regulates"| Fibrosis
    Autophagy(["Autophagy"])
    HSP27 -->|"regulates"| Autophagy
    P62["P62"]
    P62 -->|"regulates"| HSP27
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"regulates"| HSP27
    CTSH["CTSH"]
    CTSH -->|"interacts with"| HSP27
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| HSP27
    C1QB["C1QB"]
    C1QB -->|"interacts with"| HSP27
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| HSP27
    SOD1["SOD1"]
    SOD1 -->|"activates"| HSP27
    IRS1["IRS1"]
    IRS1 -->|"interacts with"| HSP27
    CANCER["CANCER"]
    CANCER -->|"interacts with"| HSP27
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| HSP27
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"therapeutic target"| HSP27
    HSP70["HSP70"]
    HSP70 -->|"therapeutic target"| HSP27
    style HSP27 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (109)

Target	Relation	Type	Str
Phase Condensates	modulates	mechanism	0.90
Proteostasis	regulates	process	0.90
proteostasis	regulates	process	0.85
protein aggregation	suppresses	process	0.85
Phosphorylation	associated_with	process	0.85
AKT	regulates	gene	0.70
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	regulates	disease	0.65
Ms	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	treats	disease	0.65
PARKINSON'S DISEASE	treats	gene	0.60
PARKINSON	treats	gene	0.60
AMYLOID	treats	gene	0.60
AUTOPHAGY	treats	gene	0.60
Autophagy	treats	pathway	0.60
Chaperone	treats	pathway	0.60
Lysosomal Degradation	treats	pathway	0.60
MITOPHAGY	treats	gene	0.60
Mitophagy	treats	pathway	0.60
ALS	regulates	gene	0.60
Tdp-43	inhibits	pathway	0.60
Amyloid	inhibits	pathway	0.60
Sod1	inhibits	pathway	0.60
HSP70	treats	gene	0.60
ATG13	inhibits	gene	0.60
BECLIN1	inhibits	gene	0.60
HSP70	expressed_in	gene	0.60
EIF2A	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TAU	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
HIF	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
CANCER	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
Mtor	regulates	pathway	0.60
Epithelial-Mesenchymal Transition	regulates	pathway	0.60

Incoming (42)

Source	Relation	Type	Str
Lysosomal Damage	associated_with	process	0.80
C1QB	interacts_with	gene	0.60
SOD1	activates	gene	0.60
APP	inhibits	gene	0.60
TDP-43	inhibits	gene	0.60
HSP70	expressed_in	gene	0.60
TAU	inhibits	gene	0.60
ATG16L1	expressed_in	gene	0.60
SOD1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
HSP90	expressed_in	gene	0.60
EIF2A	inhibits	gene	0.60
BECLIN1	inhibits	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
ASTROCYTES	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
CTSH	interacts_with	gene	0.60
PROTEIN MISFOLDING	regulates	gene	0.60
IRS1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
HSP70	therapeutic_target	gene	0.60
CFTR	regulates	gene	0.60
PKC	regulates	gene	0.60
ATG13	inhibits	gene	0.60
MIRNAS	regulates	gene	0.60
P62	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
HER2	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
Autophagy	regulates	process	0.50
P62/SQSTM1	regulates	protein	0.50
GRP78	expressed_in	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the therapeutic window between insufficient and toxic levels of TDP-43 a

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.848

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate highlighted a critical dosing paradox where both hypo- and hypermethy

closed · Rounds: 4 · Score: 0.82 · 2026-04-12

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning HSP27 in their description or question text

No additional research found