gene 1,505 words KG: ent-gene-ed5fed2c
Contents

ATG13 — Autophagy Related 13

🧬 Gene Info
Gene SymbolATG13
Full NameAutophagy Related 13
Chromosome11p11.2
Functionis a critical gene encoding a key regulator of the autophagy initiation machinery in eukaryotic cells.
Molecular Weight60 kDa
Amino Acids559 aa
PathwaysApoptosis, Autophagy, Complement, Ferroptosis, Glycolysis
UniProt ID[Q9UQL6](https://www.uniprot.org/uniprot/Q9UQL6)
Ensembl IDENSG00000152256
OMIM614608
GeneCardsATG13
Human Protein AtlasATG13
Hor domain (HR)Located at the N-terminus, mediates protein-protein interactions
LIR (LC3-interacting region)At the C-terminus, enables binding to LC3/GABARAP family proteins
UBAN-like motifFacilitates interaction with specific autophagy receptors
Associated Diseasesneurodegeneration
InteractionsAGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections186 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.88
Circadian Clock-Autophagy Synchronization
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
VCP-Mediated Autophagy Enhancement
Score: 0.59

Related Analyses (7)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed

Related Experiments (1)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
ATG1
gene · KG edge: interacts_with

Knowledge Graph (2 edges)

ent-gene-ed5fed2c data_in benchmark_ot_ad_answer_key:ATG13
benchmark_ot_ad_answer_key:ATG13 data_in ent-gene-ed5fed2c

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