gene

atg101

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about atg101: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

41Outgoing

13Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ATG101
Chromosome	14q24.2
Function	Complex stabilization: ATG101 binds to both ULK1 and ATG13, preventing their degradation
Molecular Weight	200 kDa
Amino Acids	271 aa
UniProt ID	Q9Y4P1
NCBI Gene ID	84888
Ensembl ID	ENSG00000160072
OMIM	618328
GeneCards	ATG101
Human Protein Atlas	ATG101
ULK1/2	Serine/threonine kinases that initiate autophagy
ATG101	Scaffold protein stabilizing the complex
FIP200	Focal adhesion kinase family interacting protein of 200 kDa
ATG13	Regulatory subunit with multiple phosphorylation sites
Associated Diseases	neurodegeneration
Interactions	ATG13, C9ORF72, RB1CC1, ULK1
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: atg101 — AlphaFold Q9Y4P1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

atg101

gene · 661 words

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Pathway Diagram

graph TD
    ATG101["ATG101"]
    ATG101 -->|"interacts"| ULK1["ULK1"]
    ATG101 -->|"interacts"| Autophagy["Autophagy"]
    ATG101 -->|"interacts"| Parkinson["Parkinson"]
    ATG101 -->|"activates"| Als["Als"]
    ATG101 -->|"inhibits"| Dementia["Dementia"]
    ATG101 -->|"inhibits"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ATG101 -->|"inhibits"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ATG["ATG"] -->|"component_of"| ATG101
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"interacts"| ATG101
    ATG14L["ATG14L"] -->|"activates"| ATG101
    ATG13["ATG13"] -->|"interacts"| ATG101
    ZDHHC13["ZDHHC13"] -->|"activates"| ATG101
    AUTOPHAGY["AUTOPHAGY"] -->|"interacts"| ATG101
    LYSOSOME["LYSOSOME"] -->|"activates"| ATG101

Outgoing (41)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG101	data_in	dataset_row	0.00
ULK1	interacts_with	gene	0.70
Autophagy	interacts_with	pathway	0.70
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	inhibits	disease	0.65
ULK1	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
Complement	interacts_with	pathway	0.60
Mitophagy	interacts_with	pathway	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALS	inhibits	gene	0.60
ATG13	regulates	gene	0.60
ATG5	regulates	gene	0.60
MTOR	regulates	gene	0.60
PRKAA1	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
T Cell	expressed_in	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
PARKIN	interacts_with	gene	0.60
ATG13	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
ATG9A	interacts_with	gene	0.60
LC3	inhibits	gene	0.60
C9ORF72	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
ATG5	expressed_in	gene	0.60
Neuron	expressed_in	cell_type	0.55
ULK1	interacts_with	gene	0.50
C9ORF72	interacts_with	gene	0.50
RB1CC1	interacts_with	gene	0.50
Autophagy	interacts_with	process	0.50
ATG13	interacts_with	protein	0.50

Incoming (13)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG101	data_in	dataset_row	0.00
ATG	component_of	gene	0.80
ATG14L	activates	gene	0.60
ATG	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.60
RNA	inhibits	gene	0.60
AMPK	regulates	gene	0.60
ATG13	interacts_with	gene	0.60
ZDHHC13	activates	gene	0.60
FIP200	interacts_with	gene	0.60
NBR1	inhibits	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning atg101 in their description or question text

No additional research found