gene

GABRA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

294Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

10Experiments

1Debates

Summary

Comprehensive analysis of GABRA1 gene in neurodegenerative diseases including Alzheimer's and Parkinson's, covering molecular biology, protein function, disease mechanisms, and therapeutic targets

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GABRA1
Chromosome	5q34
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Positive allosteric modulator of GABA-A receptor
Mechanism of Action	GABRA1 mediates inhibitory neurotransmission through GABA-A receptor subunit composition, modulating neuronal excitability and synaptic signaling. In neurodegeneration contexts, alterations in GABRA1 expression or function can contribute to neuronal hyperexcitability, oxidative stress, and potentially accelerated cellular damage mechanisms associated with progressive neurological disorders.
Subcellular Localization	postsynaptic sites, where it clusters at synaptic junctions through interactions with gephyrin and other scaffold protei
Druggability	High (0.90)
Clinical Stage	Approved
Molecular Weight	51 kDa
Amino Acids	456 aa
Exons	11
Pathways	GABA-A receptor / inhibitory neurotransmission
UniProt ID	P14867
GeneCards	GABRA1
Human Protein Atlas	GABRA1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	beta-sitosterol
Interactions	AMYLOID, APOE, App, AQP4, C1Q, CACNA1B
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Biorhythmic Interference via Controlled Sleep Osci
KG Connections	294 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — GABRA1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6D6U — X-ray / Cryo-EM

🔮 AI Predicted Structure

P14867 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GABRA1 Gene

gene · 2606 words

→

GABRA1 Protein

protein · 526 words

→

Pathway Diagram

flowchart TD
    GABRA1["GABRA1
GABA-A Receptor
Alpha-1 Subunit"]
    GABA_signaling["GABAergic
Neurotransmission"]
    Neuronal_inhibition["Neuronal
Inhibition"]
    
    APOE["APOE
Apolipoprotein E"]
    CHAT["CHAT
Choline
Acetyltransferase"]
    DNA_meth["DNA Methylation
Pathway"]
    Epigenetic["Epigenetic
Regulation"]
    
    Alzheimer["Alzheimer's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    Dementia["Dementia"]
    Epilepsy["Epilepsy"]
    Depression["Depression"]
    Anxiety["Anxiety
Disorders"]
    
    Aging["Aging
Process"]
    Neurodegeneration["Neurodegeneration"]
    Cognitive_decline["Cognitive
Decline"]
    
    GABRA1 -->|"encodes"| GABA_signaling
    GABA_signaling -->|"promotes"| Neuronal_inhibition
    
    DNA_meth -->|"regulates"| GABRA1
    Epigenetic -->|"modulates"| GABRA1
    
    GABRA1 -->|"associated_with"| APOE
    GABRA1 -->|"associated_with"| CHAT
    
    GABRA1 -->|"therapeutic_target"| Dementia
    GABRA1 -->|"associated_with"| Alzheimer
    GABRA1 -->|"inhibits"| ALS
    GABRA1 -->|"associated_with"| Epilepsy
    GABRA1 -->|"associated_with"| Depression
    GABRA1 -->|"associated_with"| Anxiety
    
    GABRA1 -->|"inhibits"| Aging
    Aging -->|"promotes"| Neurodegeneration
    Neurodegeneration -->|"leads_to"| Cognitive_decline
    
    style GABRA1 fill:#006494
    style GABA_signaling fill:#1b5e20
    style Neuronal_inhibition fill:#1b5e20
    style DNA_meth fill:#4a1a6b
    style Epigenetic fill:#4a1a6b
    style APOE fill:#4a1a6b
    style CHAT fill:#4a1a6b
    style Alzheimer fill:#ef5350
    style ALS fill:#ef5350
    style Dementia fill:#ef5350
    style Aging fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Epilepsy fill:#5d4400
    style Depression fill:#5d4400
    style Anxiety fill:#5d4400
    style Cognitive_decline fill:#5d4400

Outgoing (188)

Target	Relation	Type	Str
Gaba-A Receptor	involved_in	receptor	0.95
Epilepsy	causes	disease	0.95
Blindness	causes	phenotype	0.90
Blindness	associated_with	phenotype	0.90
Optic Atrophy	causes	phenotype	0.85
GABRG2	interacts_with	gene	0.85
Insomnia	therapeutic_target	disease	0.85
BLINDNESS	causes	disease	0.80
puerarin-induced_intestinal_fat_loss	required_for	process	0.80
EPILEPSY	associated_with	disease	0.80
EPILEPSY	causes	disease	0.80
SNAP25	activates	gene	0.70
SYN1	activates	gene	0.70
NOTCH	transports	gene	0.70
GRIA1	activates	gene	0.70
GRIN2A	activates	gene	0.70
Central Precocious Puberty	involved_in	disease	0.70
CA1	phosphorylates	brain_region	0.70
ASTROCYTES	causes	cell_type	0.70
AMYLOID	activates	protein	0.70
ALS	causes	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Aging	causes	disease	0.65
Cancer	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Central Precocious Puberty	implicated_in	disease	0.65
Obesity	regulates	disease	0.65
Aging	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Aging	inhibits	disease	0.65
inhibitory neurons	expressed_in	cell_type	0.65
Epilepsy	associated_with	disease	0.65
Obesity	inhibits	disease	0.65
neurons	expressed_in	cell_type	0.65
Anxiety	associated_with	disease	0.65
autophagy pathway	participates_in	pathway	0.60
GABAergic neurons	expressed_in	cell_type	0.60
ICPP	associated_with	disease	0.60

Incoming (106)

Source	Relation	Type	Str
h-49791706	targets	hypothesis	0.90
puerarin	binds_to	compound	0.90
Haploinsufficiency	associated_with	process	0.85
GABAERGIC	activates	cell_type	0.70
TAU	treats	protein	0.70
GABA	inhibits	phenotype	0.70
NEURONS	inhibits	cell_type	0.70
beta-sitosterol	targets	compound	0.70
GAIN	inhibits	gene	0.60
GABRG2	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
CYP2E1	associated_with	gene	0.60
MKRN3	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
PUERARIN	activates	gene	0.60
PER	therapeutic_target	gene	0.60
DLK1	interacts_with	gene	0.60
CACNA1H	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
TACR3	associated_with	gene	0.60
LIN28B	associated_with	gene	0.60
PER	interacts_with	gene	0.60
ABCB1	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
APOE	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
DLK1	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Biorhythmic Interference via Controlled Sleep Oscillations	0.661	neurodegeneration	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.729

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Phenobarbital treatment efficacy study	clinical	intractable epilepsy	0.900	0.00	human patient and Gabra1+/-/Ga	proposed	N/A
Gabra1+/-/Gabrg2+/- mouse model characterization	validation	epilepsy with optic atrophy	0.900	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
Optic nerve myelination analysis	exploratory	optic atrophy	0.880	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
GABAA receptor subunit expression analysis	exploratory	epilepsy	0.850	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Neural Oscillation Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
A brain-to-gut signal controls intestinal fat absorption. [PMID:39261733]	Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB,	Nature	2024	1
Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human [PMID:37703949]	Zhang Q, Forster-Gibson C, Bercovici E,	Exp Neurol	2023	1
Pharmacogenetics of anxiety and depression in Alzheimer's disease. [PMID:36628952]	Cacabelos R, Carril JC, Corzo L, Pego R,	Pharmacogenomics	2023	1
Genetic factors in precocious puberty. [PMID:34665958]	Shim YS, Lee HS, Hwang JS	Clin Exp Pediatr	2022	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Prenatal alcohol exposure dysregulates the expression of clock genes and alters [PMID:41086861]	Reina-Campos M, Gallego-Landin I, Medran	Open biology	2025	0
Sleep-improving effect and the potential mechanism of Morus alba L. on mice. [PMID:39255910]	Kong X, Zhou X, Li R, Kang Q, Hao L, Zhu	Fitoterapia	2024	0
To beat Omicron, Delta and bird flu, Europe must pull together [PMID:34893768]	Desvars-Larrive Amélie	Nature	2021	0
Facilitating successful online meetings in healthcare. [PMID:33789331]	Dennis Sherrod; Cecil Holland	Nursing management	2021	0
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213]	["Su Z", "Zhang K", "Kappel K", "Li S",	Nature	2021	0
A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa [PMID:32047260]	["Yan Y", "Shi K", "Teng F", "Chen J", "	Acta pharmacologica Sinica	2020	0
AAV Capsid-Promoter Interactions Determine CNS Cell-Selective Gene Expression In [PMID:32213322]	["Powell S", "Samulski R", "McCown T"]	Molecular therapy : the journa	2020	0
Precision medicine treatment in acute myeloid leukemia using prospective genomic [PMID:33106665]	["Burd A", "Levine R", "Ruppert A", "Mim	Nature medicine	2020	0
Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molec [PMID:29937276]	["Readhead B", "Haure-Mirande J", "Funk	Neuron	2018	0
Formal group insertion into aryl C‒N bonds through an aromaticity destruction-re [PMID:30143605]	["Han D", "He Q", "Fan R"]	Nature communications	2018	0
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial ap [PMID:23589839]	["Nieminen A", "Eskelinen V", "Haikala H	Proceedings of the National Ac	2013	0

Debates (1)

Multi-agent debates referencing this entity

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning GABRA1 in their description or question text

No additional research found