gene

GRIK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

0Experiments

0Debates

Summary

Page for GRIK4 - Glutamate Receptor Kainate Type Subunit 4

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🧬 Gene Info

Gene Symbol	GRIK4
Full Name	Glutamate Ionotropic Kainate Type Subunit 4
Aliases	Page for GRIK4, Page for GRIK4 Protein
Chromosome	21q21.3
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	100 kDa
Amino Acids	906 aa
Exons	16
UniProt ID	Q16479
NCBI Gene ID	2899
Ensembl ID	ENSG00000160225
OMIM	604153
GeneCards	GRIK4
Human Protein Atlas	GRIK4
Associated Diseases	Alzheimer, Autism, Bipolar, Cancer, Depression, Inflammation
Interactions	CACNA1B, CACNA1H, DRD1, DRD2, GABRA1, GABRB2
KG Connections	88 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GRIK4 — AlphaFold Q16479 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRIK4["GRIK4"]
    Ms{"Ms"}
    GRIK4 -->|"therapeutic target"| Ms
    Depression{"Depression"}
    GRIK4 -->|"therapeutic target"| Depression
    GRIK4 -->|"associated with"| Depression
    SLC6A4["SLC6A4"]
    GRIK4 -->|"associated with"| SLC6A4
    KCNK2["KCNK2"]
    GRIK4 -->|"associated with"| KCNK2
    Complement(["Complement"])
    GRIK4 -->|"therapeutic target"| Complement
    Neurogenesis(["Neurogenesis"])
    GRIK4 -->|"therapeutic target"| Neurogenesis
    BDNF["BDNF"]
    GRIK4 -->|"associated with"| BDNF
    GRIK4 -->|"associated with"| Neurogenesis
    GRIK4 -->|"associated with"| Complement
    TRD{"TRD"}
    GRIK4 -->|"associated with"| TRD
    neurodegeneration["neurodegeneration"]
    GRIK4 -->|"implicated in"| neurodegeneration
    BDNF -->|"associated with"| GRIK4
    GENES["GENES"]
    GENES -->|"associated with"| GRIK4
    SLC6A4 -->|"associated with"| GRIK4
    DEPRESSION["DEPRESSION"]
    DEPRESSION -->|"associated with"| GRIK4
    KCNK2 -->|"associated with"| GRIK4
    AND["AND"]
    AND -->|"associated with"| GRIK4
    style GRIK4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (59)

Target	Relation	Type	Str
Depression	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Neurogenesis	associated_with	pathway	0.60
Complement	associated_with	pathway	0.60
App	therapeutic_target	protein	0.60
BDNF	associated_with	gene	0.60
Actin	therapeutic_target	protein	0.60
Bdnf	associated_with	protein	0.60
GRM5	interacts_with	gene	0.60
AND	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Rb	associated_with	protein	0.60
HTR2C	interacts_with	gene	0.60
Complement	therapeutic_target	pathway	0.60
Neurogenesis	therapeutic_target	pathway	0.60
KCNK2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
GABAergic neurons	expressed_in	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Dopaminergic	associated_with	cell_type	0.60
DEPRESSION	associated_with	gene	0.60
TRD	associated_with	disease	0.56
Hypothalamus	expressed_in	brain_region	0.55
Cerebellum	expressed_in	brain_region	0.55
Thalamus	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55

Incoming (29)

Source	Relation	Type	Str
KCNK2	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
CACNA1H	interacts_with	gene	0.60
GABRB2	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
HTR2C	interacts_with	gene	0.50
DRD1	interacts_with	gene	0.50
DRD2	interacts_with	gene	0.50
GABRA1	interacts_with	gene	0.50
GRM5	interacts_with	gene	0.50
CACNA1B	interacts_with	gene	0.50
BDNF	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIK4 in their description or question text

No additional research found