gene

SLC6A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

202Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Norepinephrine transporter gene critical for noradrenergic signaling in brain and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	SLC6A2
Full Name	Norepinephrine Transporter
Chromosome	16q12.2
Protein Type	Transporter
Function	is a gene encoding a critical membrane transport protein responsible for the reuptake of norepinephrine (noradrenaline) from the synaptic cleft back into presynaptic neurons.
Primary Expression	noradrenergic neurons of the central nervous system:
Molecular Weight	70 kDa
Amino Acids	617 aa
Pathways	Epigenetic, autophagy pathway
UniProt ID	[P23975](https://www.uniprot.org/uniprot/P23975)
Ensembl ID	ENSG00000170270
OMIM	163910
GeneCards	SLC6A2
Human Protein Atlas	SLC6A2
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Anxiety, Autism
Known Drugs/Compounds	antidepressant drugs
Interactions	Actin, CACNA1B, CACNA1H, DNA, DRD1, DRD2
KG Connections	202 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A2 — Norepinephrine Transporter

gene · 1544 words

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Pathway Diagram

graph TD
    SLC6A2["SLC6A2"]
    SLC6A2 -->|"target for"| Dementia["Dementia"]
    SLC6A2 -->|"activates"| Parkinson["Parkinson"]
    SLC6A2 -->|"activates"| Als["Als"]
    SLC6A2 -->|"activates"| ALS["ALS"]
    SLC6A2 -->|"target for"| Epigenetic["Epigenetic"]
    SLC6A2 -->|"activates"| JUN["JUN"]
    GENES["GENES"] -->|"target for"| SLC6A2
    JUN -->|"activates"| SLC6A2
    DNA["DNA"] -->|"activates"| SLC6A2
    PER["PER"] -->|"interacts"| SLC6A2
    GPNMB["GPNMB"] -->|"transports"| SLC6A2
    NUCKS1["NUCKS1"] -->|"transports"| SLC6A2
    CYP2D6["CYP2D6"] -->|"transports"| SLC6A2

Outgoing (114)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SLC6A2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
antidepressant drugs	therapeutic_target	drug	0.80
Inflammation	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	protects_against	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	protects_against	disease	0.65
Dementia	associated_with	disease	0.65
Als	activates	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Autism	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Cancer	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
JUN	activates	gene	0.60
CYP2D6	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
APOE	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
Epigenetic	activates	pathway	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
Epigenetic	interacts_with	pathway	0.60
DNA	activates	gene	0.60
GENES	transports	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60

Incoming (88)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SLC6A2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
LRRK2	transports	gene	0.60
SLC6A4	transports	gene	0.60
GCH1	transports	gene	0.60
ABCB1	transports	gene	0.60
DRD2	transports	gene	0.60
SNCA	transports	gene	0.60
CYP3A4	transports	gene	0.60
CYP2D6	transports	gene	0.60
APOE	transports	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
SLC1A1	interacts_with	gene	0.60
CYP2C19	associated_with	gene	0.60
SLC6A3	transports	gene	0.60
DNA	activates	gene	0.60
GENES	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
CYP3A5	associated_with	gene	0.60
AND	transports	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
GENES	transports	gene	0.60
PARKINSON	activates	gene	0.60
PER	therapeutic_target	gene	0.60
CYP2D6	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GRM5	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC6A2 in their description or question text

No additional research found