gene

CYP2D6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP2D6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

250Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CYP2D6 encodes a key drug-metabolizing enzyme with over 100 known alleles affecting drug response. Strongly implicated in Parkinson's disease risk through metabolism of neurotoxins and neuroprotective compounds.

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🧬 Gene Info

Gene Symbol	CYP2D6
Full Name	Cytochrome P450 2D6
Protein Type	Enzyme
Function	encodes a crucial phase I drug-metabolizing enzyme that plays a pivotal role in the metabolism of approximately 25% of all clinically used drugs.
Molecular Weight	56 kDa
Amino Acids	497 aa
Pathways	Oxidative Stress
Ensembl ID	ENSG00000100168
GeneCards	CYP2D6
Human Protein Atlas	CYP2D6
Catalytic reaction type	Hydroxylation, O-dealkylation, N-dealkylation
Cofactor requirement	NADPH-cytochrome P450 reductase
Substrate preference	Planar aromatic compounds with a nitrogen-containing basic group
Optimal pH	7.4 (physiological)
Molecular weight	~56 kDa
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Anxiety
Known Drugs/Compounds	antidepressant drugs
Interactions	ABCB1, Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, BID
KG Connections	250 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CYP2D6 — Cytochrome P450 2D6

gene · 2233 words

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Pathway Diagram

graph TD
    CYP2D6["CYP2D6"]
    CYP2D6 -->|"target for"| Dementia["Dementia"]
    CYP2D6 -->|"activates"| Parkinson["Parkinson"]
    CYP2D6 -->|"activates"| Als["Als"]
    CYP2D6 -->|"target for"| Ms["Ms"]
    CYP2D6 -->|"activates"| ALS["ALS"]
    CYP2D6 -->|"target for"| Epigenetic["Epigenetic"]
    JUN["JUN"] -->|"activates"| CYP2D6
    GENES["GENES"] -->|"target for"| CYP2D6
    DNA["DNA"] -->|"activates"| CYP2D6
    PER["PER"] -->|"interacts"| CYP2D6
    GPNMB["GPNMB"] -->|"transports"| CYP2D6
    NUCKS1["NUCKS1"] -->|"transports"| CYP2D6

Outgoing (152)

Target	Relation	Type	Str
antidepressant drugs	modulates	drug	0.85
Fibrosis	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	regulates	disease	0.65
Lung Cancer	associated_with	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Dementia	transports	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	transports	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Cancer	causes	disease	0.65
Fibrosis	causes	disease	0.65
Vascular Dementia	transports	disease	0.65
Aging	interacts_with	disease	0.65
Als	causes	disease	0.65
Hepatitis	regulates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	protects_against	disease	0.65
Dementia	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Parkinson	associated_with	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
CYP3A4	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60

Incoming (98)

Source	Relation	Type	Str
GENES	causes	gene	0.60
CYP1A1	associated_with	gene	0.60
NR1I2	therapeutic_target	gene	0.60
SLC6A2	affects	gene	0.60
ABCB1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CANCER	causes	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CYP2C19	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
JUN	activates	gene	0.60
SLC6A3	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
DES	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60
XRCC1	causes	gene	0.60
TP53	causes	gene	0.60
CHAT	therapeutic_target	gene	0.60
CYP3A4	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
PPAR	transports	gene	0.60
CHAT	transports	gene	0.60
ACE	transports	gene	0.60
BCHE	transports	gene	0.60
CHRNA7	transports	gene	0.60
CHRNA7	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYP2D6 in their description or question text

No additional research found