concept

PUERARIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PUERARIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

97Connections

0Hypotheses

0Analyses

50Outgoing

25Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PUERARIN
Key Genes/Proteins	Actin, AGING, AKT, AKT1, ALZHEIMER, AMPK
Related Diseases	Aging, Als, Alzheimer
Related Pathways	Angiogenesis, Apoptosis, Autophagy

Pathway Diagram

graph TD
    PUERARIN["PUERARIN"]
    PUERARIN -->|"activates"| AMPK["AMPK"]
    PUERARIN -->|"target for"| Oxidative_Stress["Oxidative Stress"]
    PUERARIN -->|"target for"| Angiogenesis["Angiogenesis"]
    PUERARIN -->|"inhibits"| Obesity["Obesity"]
    PUERARIN -->|"target for"| Aging["Aging"]
    PUERARIN -->|"target for"| Senescence["Senescence"]
    PUERARIN -->|"target for"| Stroke["Stroke"]
    PUERARIN -->|"target for"| Ischemia["Ischemia"]
    PUERARIN -->|"target for"| Inflammation["Inflammation"]
    PUERARIN -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"target for"| PUERARIN
    GAIN["GAIN"] -->|"inhibits"| PUERARIN
    GABRA1["GABRA1"] -->|"activates"| PUERARIN
    ROS["ROS"] -->|"target for"| PUERARIN
    NATURAL_COMPOUNDS["NATURAL COMPOUNDS"] -->|"treats"| PUERARIN
    STROKE["STROKE"] -->|"target for"| PUERARIN
    APOPTOSIS["APOPTOSIS"] -->|"target for"| PUERARIN
    GASTRODIN["GASTRODIN"] -->|"treats"| PUERARIN
    AKT1["AKT1"] -->|"activates"| PUERARIN
    TNF["TNF"] -->|"inhibits"| PUERARIN

Outgoing (72)

Target	Relation	Type	Str
GABRA1	binds_to	gene	0.90
DMV-vagus_pathway	inhibits	biological_pathway	0.80
Angiogenesis	therapeutic_target	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
AMPK	activates	gene	0.70
Neuroinflammation	regulates	disease	0.65
Als	inhibits	disease	0.65
Sepsis	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Als	associated_with	disease	0.65
Depression	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Obesity	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
FLAVONOIDS	treats	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
INFLAMMATION	therapeutic_target	gene	0.60
Neurogenesis	therapeutic_target	pathway	0.60
BRAIN INJURY	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
PI3K	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
Oxidative Stress	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Microglia	activates	cell_type	0.60
T Cell	associated_with	cell_type	0.60
Neuron	activates	cell_type	0.60
AKT	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
AKT	activates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
GDNF	activates	gene	0.60
BDNF	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60

Incoming (25)

Source	Relation	Type	Str
OXIDATIVE STRESS	therapeutic_target	gene	0.70
STROKE	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
GASTRODIN	treats	gene	0.60
NATURAL COMPOUNDS	treats	gene	0.60
TNF	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
ROS	therapeutic_target	gene	0.60
AKT1	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
NRF2	activates	gene	0.60
JNK	inhibits	gene	0.60
NGF	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
C-JUN	inhibits	gene	0.60
AKT	inhibits	gene	0.60
GDNF	activates	gene	0.60
MICROGLIA	activates	gene	0.60
BDNF	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMPK	interacts_with	gene	0.60
GAIN	inhibits	gene	0.60
GABRA1	activates	gene	0.60
GABRA1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PUERARIN in their description or question text

No additional research found