concept

CA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

382Connections

7Hypotheses

3Analyses

50Outgoing

50Incoming

11Experiments

4Debates

Summary

CA1 is a concept in neurodegeneration research. Key relationships include: co discussed, protects against, interacts with. Associated with DEPRESSION. Connected to 16 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CA1
Key Genes/Proteins	ABCA1, ACHE, AMYLOID, AMYLOID-BETA, APOE, APP
Related Diseases	AGING, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE, AMYLOID PLAQUES
Linked Hypotheses	21 hypotheses

🔮 Predicted Structure: CA1 — AlphaFold P00915 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CA1["CA1"]
    ketamine["ketamine"] -->|"activates"| CA1
    ABCA1["ABCA1"] -->|"expressed in"| CA1
    MTOR["MTOR"] -->|"expressed in"| CA1
    P62["P62"] -->|"expressed in"| CA1
    LC3["LC3"] -->|"expressed in"| CA1
    APOE["APOE"] -->|"expressed in"| CA1
    SQSTM1["SQSTM1"] -->|"expressed in"| CA1
    LDL["LDL"] -->|"expressed in"| CA1
    AMPK["AMPK"] -->|"expressed in"| CA1
    ACTB["ACTB"] -->|"expressed in"| CA1

Outgoing (62)

Target	Relation	Type	Str
iron enrichment	associated_with	phenotype	0.95
selective vulnerability to neurodegeneration	associated_with	phenotype	0.90
hippocampal sclerosis	associated_with	phenotype	0.80
SYNAPTIC PLASTICITY	treats	phenotype	0.70
CHOLESTEROL	regulates	phenotype	0.70
TAU	treats	protein	0.70
subiculum	spreads_to	brain_region	0.70
SYNAPTIC PLASTICITY	regulates	phenotype	0.70
AGING	causes	phenotype	0.70
AGING	interacts_with	phenotype	0.70
HIPPOCAMPUS	exacerbates	brain_region	0.65
MICROGLIA	expressed_in	cell_type	0.65
MICROGLIA	degrades	cell_type	0.65
NEURODEGENERATION	activates	disease	0.65
NEURON	degrades	cell_type	0.65
NEURONS	degrades	cell_type	0.65
NLRP3	degrades	gene	0.65
LOCUS COERULEUS	exacerbates	brain_region	0.65
GABAERGIC	inhibits	cell_type	0.65
GLUTAMATERGIC	inhibits	cell_type	0.65
NEURON	increases	cell_type	0.65
NEURONS	increases	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
METFORMIN	protects_against	drug	0.65
DEPRESSION	activates	disease	0.65
TAU	interacts_with	gene	0.65
MICROGLIA	impairs	cell_type	0.65
PSD95	regulates	gene	0.65
DENTATE GYRUS	regulates	brain_region	0.65
ENTORHINAL CORTEX	inhibits	brain_region	0.65
TAU	inhibits	gene	0.65
AGING	biomarker_for	phenotype	0.65
P2RX7	inhibits	gene	0.60
NEURON	protects_against	cell_type	0.60
GFAP	protects_against	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
NEURON	interacts_with	cell_type	0.60
NEURONS	interacts_with	cell_type	0.60
MICROGLIA	causes	cell_type	0.60
NEURON	regulates	cell_type	0.60
MICROGLIA	inhibits	cell_type	0.60
PYRAMIDAL	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
INTERNEURON	regulates	cell_type	0.60
ROS	associated_with	phenotype	0.50
METFORMIN	associated_with	drug	0.45
TAU	associated_with	protein	0.45
PSD95	co_discussed	gene	0.40
DENTATE GYRUS	co_discussed	brain_region	0.40

Incoming (320)

Source	Relation	Type	Str
pyramidal neurons	expressed_in	cell_type	1.00
AMYLOID	treats	protein	0.70
GABRA1	phosphorylates	gene	0.70
AMYLOID	regulates	protein	0.70
NEURON	treats	cell_type	0.70
CORTEX	causes	brain_region	0.70
TAU	protects_against	protein	0.70
APP	stabilizes	gene	0.70
HDAC3	inhibits	gene	0.70
ISCHEMIA	activates	disease	0.70
CA3	regulates	brain_region	0.70
ketamine	activates	drug	0.70
KETAMINE	regulates	drug	0.65
SYNAPTIC PLASTICITY	causes	phenotype	0.65
ASTROCYTE	associated_with	cell_type	0.65
AMYLOID-BETA	associated_with	gene	0.65
LACTATE	activates	phenotype	0.65
HDAC3	associated_with	gene	0.60
ALZHEIMER'S DISEASE	targets	disease	0.60
ASTROCYTES	associated_with	cell_type	0.60
ASTROCYTE	causes	cell_type	0.60
ACHE	protects_against	gene	0.60
ASTROCYTES	inhibits	cell_type	0.60
ASTROCYTE	inhibits	cell_type	0.60
BDNF	protects_against	gene	0.60
CCL5	expressed_in	gene	0.55
MICROGLIA	expressed_in	gene	0.55
ALZHEIMER	expressed_in	gene	0.55
ASTROCYTES	expressed_in	gene	0.55
TAUOPATHY	expressed_in	gene	0.55
JUN	expressed_in	gene	0.55
LIPOPHAGY	expressed_in	gene	0.55
APOE3	expressed_in	gene	0.55
CTSH	expressed_in	gene	0.55
MYOT	expressed_in	gene	0.55
PTK2B	expressed_in	gene	0.55
ACE	expressed_in	gene	0.55
PLCG2	expressed_in	gene	0.55
APP	expressed_in	gene	0.55
ABI3	expressed_in	gene	0.55
CD33	expressed_in	gene	0.55
INPP5D	expressed_in	gene	0.55
PSEN1	expressed_in	gene	0.55
TREM2	expressed_in	gene	0.55
COMPLEMENT	expressed_in	gene	0.55
TAU	expressed_in	gene	0.55
NEURON	expressed_in	gene	0.55
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.55
RNA	expressed_in	gene	0.55
AND	expressed_in	gene	0.55

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.927	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.861	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.820	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
APOE4 astrocytes exhibit impaired cholesterol efflux via ABC	0.760	neuroscience	APOE4-driven lipid metabolism dysregulat

Selective LXRβ agonists restore ABCA1/ABCG1 expression and A	0.710	neuroscience	APOE4-driven lipid metabolism dysregulat
APOE4 hypolipidation and ABCA1 mistrafficking impair cholest	0.680	molecular biology	Does APOE4's reduced lipid-binding direc

Mentioning Analyses (3)

Scientific analyses that reference this entity

Spatial Transcriptomics Analysis of Alzheimer's Disease Brain Regions

neurodegeneration | 2026-04-16 | 0 hypotheses

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 44 hypotheses Top: 0.990

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 67 hypotheses Top: 1.000

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	0.00	Spp1 knockout AD mouse models	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
Synaptic plasticity and protein expression analysis in mPFC	exploratory	insomnia-anxiety comorbidity	0.850	0.00	mPFC brain slices from PCPA-tr	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Animal Model Comparison for Neurodegenerative Disease Therapeutics	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026
Human umbilical cord mesenchymal stem cells therapy for Alzheimer's disease: a s [PMID:41847685]	Si C, Ma L, Ding W, Tian Y, Zhang J, Cao	Frontiers in neurology	2026
Cannabidiol and pBDNF Cotreatment Attenuates Pathological Symptoms and Improves [PMID:41924980]	Chaulagain B, Gothwal A, Mahanta AK, Jar	ACS chemical neuroscience	2026
Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerati [PMID:41868184]	Liu Z, Zhang H, Wan B, Yin S, Yue R	Drug design, development and t	2026
Modulation of mitochondrial quality by exercise mimetics: A potential strategy f [PMID:41804756]	Ke Z, Wang B, Liang R	Journal of Alzheimer's disease	2026
Neurotransmitter dysregulation in depression, anxiety, and suicidality: From syn [PMID:41924767]	K S V ABG, Verma AK, A SS, Sinha SS, Boy	Psychiatry research	2026
Hippocampal neural circuit mechanisms in Alzheimer's disease revealed by viral-g [PMID:41082949]	["Ye Q", "Gast G", "Holmes T", "Xu X"]	Neurobiology of disease	2025
Therapeutic Potential of Natural Compounds for Brain Ischemia-Reperfusion Injury [PMID:41007298]	["Yoo K", "Won M", "Ahn J", "Park J"]	Biology	2025

Debates (4)

Multi-agent debates referencing this entity

How does spatial gene expression in the hippocampus and entorhinal cortex distin

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Do spatial transcriptomic neighborhoods provide sufficient discriminative power

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CA1 in their description or question text

Selective LXRβ agonists restore ABCA1/ABCG1 expression and APOE lipidation in AP

Score: 0.710 · neuroscience · 2026-04-22

**Molecular Mechanism and Rationale** The molecular basis for selective liver X receptor beta (LXRβ/NR1H2) agonism in A

APOE4 hypolipidation and ABCA1 mistrafficking impair cholesterol efflux and seco

Score: 0.680 · molecular biology · 2026-04-24

A plausible upstream submechanism is that lipid-poor APOE4 disrupts ABCA1 trafficking, likely via ARF6-associated endoso

CA1

Understanding Entity Pages

Summary

Wiki Pages (21)

O-LM Cells

ABCA1 - ATP-Binding Cassette Transporter A1

ABCA1 Gene

Spinocerebellar Ataxia Type 17 (SCA17)

ABCA1→Cholesterol Efflux→APOE Lipidation→Alzheimer's Disease Causal Chain

Hippocampal CA1 Pyramidal Neurons in Aging-Related Tauopathy

ABCA1 Protein

Hippocampal CA1 Interneurons

Hippocampal CA1 Pyramidal Neurons (Expanded)

KCA1A Gene

BAP1 (BRCA1-Associated Protein 1)

BRCA1 Gene

BRCA1 Protein

Hippocampal CA1 Pyramidal Neurons in Alzheimer's Disease

Hippocampal CA1 Pyramidal Neurons

PMCA1 Protein — Plasma Membrane Calcium ATPase 1