protein

CACNA1H

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1H: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

105Connections

0Hypotheses

0Analyses

50Outgoing

44Incoming

0Experiments

0Debates

Summary

Page for CACNA1H Protein (Cav3.2 T-type Calcium Channel)

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🔬 Protein Info

Gene Symbol	CACNA1H
Full Name	Calcium Voltage-Gated Channel Subunit Alpha1 H
Aliases	Cav3.2 T-type Calcium Channel
Chromosome	16p13.3
Function	The CACNA1H gene encodes the α1H subunit that forms the pore of the T-type calcium channel (CaV3.2).
UniProt ID	O43480
NCBI Gene ID	8916
Ensembl ID	ENSG00000118260
GeneCards	CACNA1H
Human Protein Atlas	CACNA1H
Associated Diseases	Alzheimer, Autism, Bipolar, Cancer, Inflammation, Parkinson
Interactions	CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, cacna1f
KG Connections	105 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CACNA1H — AlphaFold O43480 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CACNA1H Gene

gene · 855 words

→

CACNA1H Protein (Cav3.2 T-type Calcium Channel)

protein · 755 words

→

Pathway Diagram

graph TD
    CACNA1H["CACNA1H"]
    Alzheimer["Alzheimer"]
    CACNA1H -->|"associated with"| Alzheimer
    Cancer["Cancer"]
    CACNA1H -->|"associated with"| Cancer
    Schizophrenia["Schizophrenia"]
    CACNA1H -->|"associated with"| Schizophrenia
    Autism["Autism"]
    CACNA1H -->|"associated with"| Autism
    Parkinson["Parkinson"]
    CACNA1H -->|"associated with"| Parkinson
    Bipolar["Bipolar"]
    CACNA1H -->|"associated with"| Bipolar
    Inflammation["Inflammation"]
    CACNA1H -->|"associated with"| Inflammation
    CACNA1D["CACNA1D"]
    CACNA1H -->|"associated with"| CACNA1D
    CACNA1G["CACNA1G"]
    CACNA1H -->|"associated with"| CACNA1G
    HTR2C["HTR2C"]
    CACNA1H -->|"associated with"| HTR2C
    DRD2["DRD2"]
    CACNA1H -->|"associated with"| DRD2
    PARKINSON["PARKINSON"]
    CACNA1H -->|"associated with"| PARKINSON
    Dopaminergic["Dopaminergic"]
    CACNA1H -->|"associated with"| Dopaminergic
    CCS["CCS"]
    CACNA1H -->|"contributes to"| CCS
    CACNA2D2["CACNA2D2"]
    CACNA1H -->|"associated with"| CACNA2D2
    CACNA1C["CACNA1C"]
    CACNA1H -->|"associated with"| CACNA1C
    CACNA1I["CACNA1I"]
    CACNA1H -->|"associated with"| CACNA1I
    SLC1A1["SLC1A1"]
    CACNA1H -->|"associated with"| SLC1A1
    INFLAMMATION["INFLAMMATION"]
    CACNA1H -->|"associated with"| INFLAMMATION
    GABRA1["GABRA1"]
    CACNA1H -->|"associated with"| GABRA1
    AND["AND"]
    CACNA1H -->|"associated with"| AND
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    CACNA1H -->|"associated with"| PARKINSON_S_DISEASE
    CANCER["CANCER"]
    CACNA1H -->|"associated with"| CANCER
    GENES["GENES"]
    CACNA1H -->|"associated with"| GENES
    ALZHEIMER["ALZHEIMER"]
    CACNA1H -->|"associated with"| ALZHEIMER
    GRIA1["GRIA1"]
    CACNA1H -->|"associated with"| GRIA1
    SLC6A2["SLC6A2"]
    CACNA1H -->|"associated with"| SLC6A2
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| CACNA1H
    CCS["CCS"]
    CCS -->|"contributes to"| CACNA1H
    CACNA1C["CACNA1C"]
    CACNA1C -->|"associated with"| CACNA1H

Outgoing (61)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
CACNA1C	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
Rb	associated_with	protein	0.60
INFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA2D2	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
CACNA1B	transports	gene	0.60
CACNA2D2	interacts_with	gene	0.60
GABRA1	interacts_with	gene	0.60
GRIK4	interacts_with	gene	0.60
GRM5	interacts_with	gene	0.60
HTR2A	interacts_with	gene	0.60
HTR2C	interacts_with	gene	0.60
SLC1A1	interacts_with	gene	0.60
SLC6A2	interacts_with	gene	0.60
PARKINSON	associated_with	gene	0.60
GABAergic neurons	expressed_in	cell_type	0.60
DRD2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
Dopaminergic	associated_with	cell_type	0.60
HTR2C	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CACNA1I	interacts_with	gene	0.60
DRD2	interacts_with	gene	0.60
CACNA2D1	interacts_with	gene	0.60
DRD1	interacts_with	gene	0.60
CACNA1F	associated_with	gene	0.60

Incoming (44)

Source	Relation	Type	Str
CACNA1G	interacts_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
CACNA1B	transports	gene	0.60
CACNA1A	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
CACNA1F	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
cacna1f	interacts_with	gene	0.50
CACNA1D	interacts_with	gene	0.50
CACNA2D2	interacts_with	gene	0.50
CACNA1I	interacts_with	gene	0.50
CACNA2D1	interacts_with	gene	0.50
CACNA1E	interacts_with	protein	0.50
CACNA1B	interacts_with	gene	0.50
DRD1	interacts_with	gene	0.50
GABRA1	interacts_with	gene	0.50
GRM5	interacts_with	gene	0.50
GRIK4	interacts_with	gene	0.50
SLC6A2	interacts_with	gene	0.50
SLC1A1	interacts_with	protein	0.50
HTR2A	interacts_with	protein	0.50
DRD2	interacts_with	gene	0.50
HTR2C	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CACNA1H in their description or question text

No additional research found