gene

ABCB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

591Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

ABCB1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with AD, ALS, Aging. Connected to 366 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCB1
Full Name	ATP Binding Cassette Subfamily B Member 1
Chromosome	7q21.12
Protein Type	Transporter
Target Class	Transporter
Function	encodes a 170 kDa ATP-dependent efflux transporter that is a critical component of the blood-brain barrier.
Mechanism of Action	Small molecule inhibitors to reduce efflux pump activity and enhance CNS drug penetration
Primary Expression	the cortex and hippocampus, with moderate levels in the cerebellum and brainstem
Druggability	Medium (0.47)
Clinical Stage	Phase III
Molecular Weight	170 kDa
Exons	29
Pathways	Apoptosis, Blood-Brain Barrier, Ferroptosis, Nf-Κb, Notch
Ensembl ID	ENSG00000085563
GeneCards	ABCB1
Human Protein Atlas	ABCB1
Associated Diseases	AD, Aging, Als, Alzheimer
Known Drugs/Compounds	Tariquidar, Elacridar
Interactions	ABCG2, ACOX1, Actin, AKT, APOD, APOPTOSIS
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	589 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: ABCB1 — PDB 6QEX Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCB1["ABCB1"] -->|"activates"| Cancer["Cancer"]
    ABCB1["ABCB1"] -->|"activates"| Carcinoma["Carcinoma"]
    ABCB1["ABCB1"] -->|"activates"| Ms["Ms"]
    ABCB1["ABCB1"] -->|"associated"| Alzheimer["Alzheimer"]
    ABCB1["ABCB1"] -->|"therapeutic target"| Dementia["Dementia"]
    ABCB1["ABCB1"] -->|"associated"| Depression["Depression"]
    h_84808267["h-84808267"] -->|"therapeutic target"| ABCB1["ABCB1"]
    TFR1["TFR1"] -->|"interacts"| ABCB1["ABCB1"]
    LRP1["LRP1"] -->|"interacts"| ABCB1["ABCB1"]
    CAV1["CAV1"] -->|"interacts"| ABCB1["ABCB1"]
    style ABCB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (418)

Target	Relation	Type	Str
R-HSA-382556	member_of	pathway	1.00
R-HSA-2161517	member_of	pathway	1.00
R-HSA-9757110	member_of	pathway	1.00
R-HSA-9754706	member_of	pathway	1.00
Cancer	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Alzheimer's Disease	involved_in	disease	0.85
metabolic homeostasis	involved_in	process	0.80
antidepressant drugs	regulates	drug	0.80
Blood-Brain Barrier	involved_in	process	0.80
P_glycoprotein	encodes	protein	0.80
CANCER	therapeutic_target	gene	0.80
Tumor	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
APOE	associated_with	gene	0.70
Notch	therapeutic_target	pathway	0.70
blood-brain barrier	participates_in	pathway	0.70
hepatotoxicity	protects_against	phenotype	0.70
CANCER	activates	gene	0.70
MYC	targets	gene	0.70
neural stem cells	regulates	cell_type	0.70
Chemoresistance	therapeutic_target	pathway	0.70
Epigenetic	therapeutic_target	pathway	0.70
Inflammation	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Dementia	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	transports	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Carcinoma	activates	disease	0.65
Vascular Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Als	activates	disease	0.65
Dementia	transports	disease	0.65
Dementia	interacts_with	disease	0.65
Infection	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Leukemia	expressed_in	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65

Incoming (173)

Source	Relation	Type	Str
genes-abcb1	describes	wiki	0.95
h-84808267	targets	hypothesis	0.90
DOT1L	regulates	gene	0.80
CD44	therapeutic_target	gene	0.70
LRP1	interacts_with	gene	0.65
CAV1	interacts_with	gene	0.65
TFR1	interacts_with	gene	0.65
POR	therapeutic_target	gene	0.60
CYP3A5	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
PLCG2	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
JUN	activates	gene	0.60
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
UBIQUITIN	biomarker_for	gene	0.60
NR3C1	interacts_with	gene	0.60
NEIL1	activates	gene	0.60
NEIL3	activates	gene	0.60
BRAF	activates	gene	0.60
NEIL2	activates	gene	0.60
MBD2	activates	gene	0.60
NOS2	therapeutic_target	gene	0.60
CCL3	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
ABCG2	expressed_in	gene	0.60
GAPDH	expressed_in	gene	0.60
CYP3A4	interacts_with	gene	0.60
HDAC6	associated_with	gene	0.60
TP53	associated_with	gene	0.60
CCT2	associated_with	gene	0.60
GUSB	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
TNF	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
IREB2	interacts_with	gene	0.60
DNAJA1	interacts_with	gene	0.60
ATP1B1	interacts_with	gene	0.60
ATP1B3	interacts_with	gene	0.60
PARP1	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning ABCB1 in their description or question text

No additional research found