gene

NEIL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEIL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

9Outgoing

2Incoming

0Experiments

0Debates

Summary

NEIL3 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Carcinoma. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NEIL3
Full Name	Nei-Like DNA Glycosylase 3
Chromosome	4q34.3
Protein Type	Enzyme
Function	encodes a DNA repair enzyme that specializes in removing oxidized purine bases from DNA, particularly in proliferating cells and neural tissue.
Primary Expression	stem cells and neural tissue, where it plays crucial roles in maintaining genomic integrity during neurogenesis and other developmental processes
Molecular Weight	60 kDa
Amino Acids	605 aa
UniProt ID	Q8TCJ1
NCBI Gene ID	55247
Ensembl ID	ENSG00000128590
OMIM	608773
GeneCards	NEIL3
Human Protein Atlas	NEIL3
8-oxoguanine (8-oxoG)	The most common oxidative DNA lesion
Associated Diseases	neurodegeneration
Interactions	ABCB1, BRAF, CANCER, ERK, NEIL1, NEIL2
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEIL3 — AlphaFold Q8TCJ1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NEIL3 Gene

gene · 1917 words

→

NEIL3 Protein

protein · 626 words

→

Pathway Diagram

graph TD
    NEIL3["NEIL3"]
    Tumor{"Tumor"}
    NEIL3 -->|"activates"| Tumor
    Als{"Als"}
    NEIL3 -->|"activates"| Als
    Cancer{"Cancer"}
    NEIL3 -->|"activates"| Cancer
    Ms{"Ms"}
    NEIL3 -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    NEIL3 -->|"activates"| Carcinoma
    CANCER["CANCER"]
    NEIL3 -->|"activates"| CANCER
    BRAF["BRAF"]
    NEIL3 -->|"activates"| BRAF
    NEIL2["NEIL2"]
    NEIL3 -->|"activates"| NEIL2
    ABCB1["ABCB1"]
    NEIL3 -->|"activates"| ABCB1
    neurodegeneration["neurodegeneration"]
    NEIL3 -->|"implicated in"| neurodegeneration
    ERK["ERK"]
    ERK -->|"activates"| NEIL3
    NEIL1["NEIL1"]
    NEIL1 -->|"activates"| NEIL3
    style NEIL3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
NEIL2	activates	gene	0.60
ABCB1	activates	gene	0.60
CANCER	activates	gene	0.60
BRAF	activates	gene	0.60

Incoming (2)

Source	Relation	Type	Str
NEIL1	activates	gene	0.60
ERK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEIL3 in their description or question text

No additional research found