gene

MBD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MBD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

14Outgoing

9Incoming

0Experiments

0Debates

Summary

Page for MBD2 Gene - Methyl-CpG Binding Domain Protein 2

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🧬 Gene Info

Gene Symbol	MBD2
Full Name	Methyl-CpG Binding Domain Protein 2
Aliases	Page for MBD2 Gene, Page for MBD2 Protein
Chromosome	18q21.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the brain with particularly high levels in:
Molecular Weight	46 kDa
Amino Acids	80 aa
UniProt ID	Q9UBT4
NCBI Gene ID	8932
Ensembl ID	ENSG00000134046
OMIM	605078
GeneCards	MBD2
Human Protein Atlas	MBD2
Methyl-CpG binding domain (MBD)	Located at the N-terminus (amino acids 144-206), this ~80 aa domain confers specificity for methylated CpG dinucleotides
Associated Diseases	Ms
Interactions	ABCB1, KMT2A
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MBD2 — AlphaFold Q9UBT4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MBD2 Gene - Methyl-CpG Binding Domain Protein 2

gene · 841 words

→

MBD2 Protein - Methyl-CpG Binding Domain Protein 2

protein · 1107 words

→

Pathway Diagram

graph TD
    MBD2["MBD2"]
    Carcinoma{"Carcinoma"}
    MBD2 -->|"regulates"| Carcinoma
    Ms{"Ms"}
    MBD2 -->|"associated with"| Ms
    Tumor{"Tumor"}
    MBD2 -->|"activates"| Tumor
    ABCB1["ABCB1"]
    MBD2 -->|"activates"| ABCB1
    KMT2A["KMT2A"]
    MBD2 -->|"activates"| KMT2A
    neurodegeneration["neurodegeneration"]
    MBD2 -->|"implicated in"| neurodegeneration
    style MBD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Carcinoma	regulates	disease	0.65
Ms	associated_with	disease	0.65
Tumor	activates	disease	0.65
Epigenetic	expressed_in	pathway	0.60
Erk	expressed_in	protein	0.60
Ras	expressed_in	protein	0.60
Pi3K	expressed_in	protein	0.60
ERK1/2	expressed_in	gene	0.60
KMT2A	activates	gene	0.60
AKT	expressed_in	gene	0.60
MAPK14	expressed_in	gene	0.60
ABCB1	activates	gene	0.60
MAPK	expressed_in	gene	0.60
Dna Methylation	expressed_in	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
RNA	expressed_in	gene	0.60
ERK	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
ADRA2A	expressed_in	gene	0.60
DNMT3B	expressed_in	gene	0.60
DNMT1	expressed_in	gene	0.60
DNMT3A	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
ADRA2B	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MBD2 in their description or question text

No additional research found