Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about hepatotoxicity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| MCC950 | causes | drug | 0.90 |
| NRF2 overactivation | causes | process | 0.90 |
| EGCG | causes | drug | 0.90 |
| caspase-3 inhibition | causes | phenotype | 0.90 |
| HSP90 inhibitors | causes | drug | 0.90 |
| MIR375 | suppresses | gene | 0.87 |
| Ginsenoside RG3 | protects_against | compound | 0.85 |
| Ginsenoside Rg3 | protects_against | compound | 0.85 |
| AKT | associated_with | gene | 0.80 |
| ABCB1 | protects_against | gene | 0.70 |
| LXR agonists | causes | drug | 0.70 |
| aloe-emodin | causes | drug | 0.70 |
| LXR_agonists | causes | drug | 0.70 |
| HSP90 inhibitors | causes | drug | 0.70 |
| REV-ERBα agonists | causes | drug | 0.70 |
| SIRT1 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.627
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.43 · 2026-04-20
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
closed · Rounds: 4 · Score: 1.00 · 2026-04-20
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
closed · Rounds: 4 · Score: 0.84 · 2026-04-11
closed · Rounds: 4 · Score: 0.86 · 2026-04-10
Hypotheses and analyses mentioning hepatotoxicity in their description or question text
No additional research found