protein

NEIL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEIL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

6Outgoing

5Incoming

0Experiments

0Debates

Summary

NEIL2 is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Carcinoma. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NEIL2
Full Name	Nei Endonuclease VIII-Like 2
Chromosome	8p23.1
Protein Family	FPG/Nei DNA Glycosylase Family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Brain (cortex, hippocampus), Testis, Liver, Kidney
Subcellular Localization	Nucleus, Mitochondria
Molecular Weight	40 kDa
UniProt ID	Q96S44
Ensembl ID	ENSG00000179119
GeneCards	NEIL2
Human Protein Atlas	NEIL2
Interactions	ABCB1, BRAF, CANCER, ERK, NEIL1, NEIL3
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NEIL2 — AlphaFold Q96S44 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NEIL2 — Nei Endonuclease VIII-Like 2

gene · 527 words

→

NEIL2 Protein

protein · 521 words

→

Pathway Diagram

graph TD
    NEIL2["NEIL2"]
    Tumor{"Tumor"}
    NEIL2 -->|"activates"| Tumor
    Als{"Als"}
    NEIL2 -->|"activates"| Als
    Cancer{"Cancer"}
    NEIL2 -->|"activates"| Cancer
    Ms{"Ms"}
    NEIL2 -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    NEIL2 -->|"activates"| Carcinoma
    ABCB1["ABCB1"]
    NEIL2 -->|"activates"| ABCB1
    neurodegeneration["neurodegeneration"]
    NEIL2 -->|"implicated in"| neurodegeneration
    ERK["ERK"]
    ERK -->|"activates"| NEIL2
    NEIL1["NEIL1"]
    NEIL1 -->|"activates"| NEIL2
    NEIL3["NEIL3"]
    NEIL3 -->|"activates"| NEIL2
    CANCER["CANCER"]
    CANCER -->|"activates"| NEIL2
    BRAF["BRAF"]
    BRAF -->|"activates"| NEIL2
    style NEIL2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	activates	disease	0.65
ABCB1	activates	gene	0.60

Incoming (5)

Source	Relation	Type	Str
NEIL1	activates	gene	0.60
NEIL3	activates	gene	0.60
BRAF	activates	gene	0.60
ERK	activates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEIL2 in their description or question text

No additional research found