protein

NUCKS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUCKS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

46Outgoing

30Incoming

0Experiments

0Debates

Summary

NUCKS1 is a protein involved in neurodegeneration research. Key relationships include: transports, associated with, activates. Associated with ALS, Als, Ms. Connected to 55 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NUCKS1
Full Name	NUCKS1, Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1
Chromosome	1q32.1
Protein Type	Kinase
Function	NUCKS1 encodes a nuclear protein that serves as a substrate for several kinases, including casein kinases and cyclin-dependent kinases.
Primary Expression	neurons and glial cells, where it may play roles in neuronal survival and response to cellular stress
Molecular Weight	66 kDa
Pathways	Epigenetic
UniProt ID	Q9H0U4
NCBI Gene ID	64766
Ensembl ID	ENSG00000138231
GeneCards	NUCKS1
Human Protein Atlas	NUCKS1
Transcriptional regulation	Modulates gene expression through chromatin remodeling
Associated Diseases	ALS, Ms, Parkinson
Interactions	Actin, DNA, JUN, PARKINSON, PARKINSON'S DISEASE
KG Connections	76 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NUCKS1 — AlphaFold Q9H0U4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NUCKS1 Gene

gene · 783 words

→

NUCKS1 Protein

protein · 664 words

→

Pathway Diagram

graph TD
    NUCKS1["NUCKS1"]
    NUCKS1 -->|"activates"| Parkinson["Parkinson"]
    NUCKS1 -->|"activates"| Als["Als"]
    NUCKS1 -->|"activates"| ALS["ALS"]
    NUCKS1 -->|"activates"| Epigenetic["Epigenetic"]
    NUCKS1 -.protects against.-> Dna_Methylation["Dna Methylation"]
    NUCKS1 -->|"transports"| CYP2D6["CYP2D6"]
    NUCKS1 -->|"transports"| SLC6A2["SLC6A2"]
    JUN["JUN"] -->|"activates"| NUCKS1
    DNA["DNA"] -->|"activates"| NUCKS1
    GPNMB["GPNMB"] -->|"transports"| NUCKS1
    SLC6A2 -->|"transports"| NUCKS1
    CYP2D6 -->|"transports"| NUCKS1
    SNCA["SNCA"] -->|"transports"| NUCKS1
    APOE["APOE"] -->|"transports"| NUCKS1
    LRRK2["LRRK2"] -->|"transports"| NUCKS1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| NUCKS1
    SLC6A3["SLC6A3"] -->|"transports"| NUCKS1

Outgoing (46)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	associated_with	disease	0.60
Epigenetic	activates	pathway	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
Actin	activates	protein	0.60
ALS	associated_with	disease	0.60
Dna Methylation	protects_against	pathway	0.60
Epigenetic	protects_against	pathway	0.60
DNA	activates	gene	0.60
GENES	transports	gene	0.60
ABCB1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
CYP2D6	transports	gene	0.60
SLC6A2	transports	gene	0.60
JUN	activates	gene	0.60
SNCA	transports	gene	0.60
GCH1	transports	gene	0.60
DRD2	transports	gene	0.60
SLC6A3	transports	gene	0.60
LRRK2	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CYP3A4	transports	gene	0.60
SLC6A4	transports	gene	0.60
GPNMB	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
AND	transports	gene	0.60
Dopaminergic	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
GPNMB	affects	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
SLC6A3	co_expressed_with	gene	0.50
SLC6A2	co_expressed_with	gene	0.50
CYP3A4	associated_with	gene	0.50

Incoming (30)

Source	Relation	Type	Str
CYP2D6	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
SLC6A4	transports	gene	0.60
GCH1	transports	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
SLC6A2	affects	gene	0.60
CYP2D6	affects	gene	0.60
SNCA	affects	gene	0.60
APOE	affects	gene	0.60
LRRK2	affects	gene	0.60
SLC6A3	affects	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2C19	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
JUN	activates	gene	0.60
SLC6A3	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GPNMB	transports	gene	0.60
DNA	activates	gene	0.60
GENES	associated_with	gene	0.60
DRD2	transports	gene	0.60
ABCB1	transports	gene	0.60
GPNMB	co_expressed_with	protein	0.50
LRRK2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NUCKS1 in their description or question text

No additional research found