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protein 708 words KG: ABCBLPROTEIN
Contents

P-glycoprotein (ABCB1)

🔬 Protein Info
Gene SymbolABCB1
Full NameATP-Binding Cassette Subfamily B Member 1 (P-glycoprotein)
Chromosome7q21.12
Protein TypeTransporter
Functionof 1,280 amino acids
Primary ExpressionBrain endothelial cells (blood-brain barrier), Liver, Kidney, Intestine
Molecular Weight170 kDa
Amino Acids280 aa
Exons28
UniProt IDP08183
NCBI Gene ID5243
Ensembl IDENSG00000065527
OMIM171040
GeneCardsABCB1
Human Protein AtlasABCB1
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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