gene

DOT1L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOT1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

DOT1L - Histone H3K79 methyltransferase involved in epigenetic regulation and neurodegeneration

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🧬 Gene Info

Gene Symbol	DOT1L
Full Name	Histone H3K79 Methyltransferase
Aliases	Disruptor of Telomeric Silencing 1-like
Protein Type	Transferase
Function	encodes a protein of 1,670 amino acids with methyltransferase activity that is conserved from yeast to humans [2](https://pubmed.
Molecular Weight	190 kDa
Amino Acids	670 aa
Pathways	Calcium Signaling, Epigenetic, Hedgehog, Nf-Κb, Toll-Like Receptor
Ensembl ID	ENSG00000100811
GeneCards	DOT1L
Human Protein Atlas	DOT1L
H3K79me1	Associated with active gene expression, enriched in gene bodies
H3K79me2	Marks transcribed genes, particularly in promoter regions
H3K79me3	Correlates with highly expressed genes and DNA damage response
Associated Diseases	AD, cancer, carcinoma, Chemoresistance, Ms, ovarian cancer
Interactions	AND, App, CANCER, GSDMD, INFLAMMATION, IRF3
KG Connections	116 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DOT1L Gene

gene · 2800 words

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DOT1L Protein

protein · 1788 words

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Pathway Diagram

graph TD
    DOT1L["DOT1L"]
    DOT1L -->|"mediates"| PARP_Inhibitor_Resistance["PARP Inhibitor Resistance"]
    DOT1L -->|"involved_in"| Ovarian_Carcinoma["Ovarian Carcinoma"]
    DOT1L -->|"inhibits"| Cancer["Cancer"]
    DOT1L -->|"activates"| Carcinoma["Carcinoma"]
    DOT1L -->|"regulates"| Ms["Ms"]
    DOT1L -->|"regulates"| Als["Als"]
    DOT1L -->|"activates"| Inflammation["Inflammation"]
    DOT1L -->|"activates"| Fibrosis["Fibrosis"]
    PARP1["PARP1"] -->|"interacts"| DOT1L
    ABCB1["ABCB1"] -->|"contributes to"| DOT1L
    PLCG2["PLCG2"] -->|"contributes to"| DOT1L
    INFLAMMATION["INFLAMMATION"] -->|"activates"| DOT1L
    TFE3["TFE3"] -->|"regulates"| DOT1L
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| DOT1L
    GSDMD["GSDMD"] -->|"activates"| DOT1L
    IRF3["IRF3"] -->|"activates"| DOT1L
    STING["STING"] -->|"activates"| DOT1L

Outgoing (84)

Target	Relation	Type	Str
Ovarian Cancer	associated_with	disease	0.90
PARP inhibitor resistance	drives	phenotype	0.90
PARP Inhibitor Resistance	mediates	phenotype	0.90
PARP INHIBITOR RESISTANCE	mediates	entity	0.90
Parp Inhibitor Resistance	mediates	phenotype	0.90
Parpi Resistance	upregulates	phenotype	0.90
PARP Inhibitor Resistance	involved_in	phenotype	0.90
Ovarian Cancer	upregulates	disease	0.85
Chemoresistance	associated_with	phenotype	0.85
OVARIAN CANCER	associated_with	entity	0.85
Ovarian Carcinoma	associated_with	disease	0.85
PARP Inhibitor Resistance	contributes_to	phenotype	0.85
survival	downregulates	phenotype	0.80
transcription	regulates	process	0.80
Chromatin Modification	involved_in	process	0.80
PARP inhibitor	biomarker_for	drug	0.80
ABCB1	regulates	gene	0.80
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	regulates	disease	0.65
OVARIAN CANCER	causes	disease	0.65
Inflammation	activates	disease	0.65
Ms	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Covid	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Senescence	regulates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
TFEB	regulates	gene	0.60
DNMT3A	regulates	gene	0.60
GENES	regulates	gene	0.60
MEIS1	regulates	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Raf	inhibits	protein	0.60
MTOR	associated_with	gene	0.60
PIEZO1	regulates	gene	0.60
CD14	regulates	gene	0.60
NLRP3	activates	gene	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
PARP1	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
Epigenetic	associated_with	pathway	0.60
RNA	regulates	gene	0.60
T Cell	associated_with	cell_type	0.60
PARP1	inhibits	entity	0.60
PLCG2	regulates	entity	0.60
AMPK	regulates	gene	0.60

Incoming (32)

Source	Relation	Type	Str
PARP1	associated_with	protein	0.90
PARP1	interacts_with	protein	0.90
UBIQUITIN	binds_to	protein	0.85
BRCA mutation	associated_with	phenotype	0.75
GSDMD	activates	gene	0.60
IRF3	activates	gene	0.60
STING	activates	gene	0.60
CD14	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
OVERVIEW	implicated_in	gene	0.60
NAMPT	associated_with	gene	0.60
ABCB1	regulates	entity	0.60
PARP1	activates	gene	0.60
TFE3	regulates	gene	0.60
RNA	regulates	gene	0.60
AND	activates	gene	0.60
BRCA	expressed_in	gene	0.60
PYROPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AND	regulates	gene	0.60
CANCER	inhibits	entity	0.60
CANCER	associated_with	entity	0.60
PLCG2	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
TLR	regulates	gene	0.60
FBXW7	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
ABCB1	associated_with	gene	0.60
ABCB1	co_expressed_with	gene	0.50
PLCG2	regulates	gene	0.50
PARP1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DOT1L in their description or question text

No additional research found