concept

NR1I2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR1I2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

0Hypotheses

0Analyses

44Outgoing

38Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NR1I2
Key Genes/Proteins	ABCB1, ACE, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE
Related Diseases	Als, ALS, Alzheimer, Cancer
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    NR1I2["NR1I2"]
    NR1I2 -->|"interacts"| DZSM["DZSM"]
    NR1I2 -->|"target for"| Alzheimer["Alzheimer"]
    NR1I2 -->|"target for"| Als["Als"]
    NR1I2 -->|"target for"| Dementia["Dementia"]
    NR1I2 -->|"transports"| Vascular_Dementia["Vascular Dementia"]
    NR1I2 -->|"transports"| ALS["ALS"]
    DZSM -->|"regulates"| NR1I2
    POR["POR"] -->|"target for"| NR1I2
    CYP3A5["CYP3A5"] -->|"target for"| NR1I2
    ALZHEIMER["ALZHEIMER"] -->|"target for"| NR1I2
    CHAT["CHAT"] -->|"target for"| NR1I2
    CYP3A4["CYP3A4"] -->|"target for"| NR1I2
    APOE["APOE"] -->|"target for"| NR1I2
    DEMENTIA["DEMENTIA"] -->|"target for"| NR1I2

Outgoing (44)

Target	Relation	Type	Str
DZSM	interacts_with	drug	0.70
Vascular Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
CHAT	therapeutic_target	gene	0.60
CYP2D6	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CYP3A5	therapeutic_target	gene	0.60
CYP3A4	therapeutic_target	gene	0.60
POR	therapeutic_target	gene	0.60
CHRNA7	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
CYP2D6	transports	gene	0.60
SLC22A1	transports	gene	0.60
CYP3A4	transports	gene	0.60
ACE	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
Ras	therapeutic_target	protein	0.60
POR	regulates	gene	0.60
PPAR	regulates	gene	0.60
SLC22A1	regulates	gene	0.60
HSP90AA1	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
Sphingolipid	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
CHRNA7	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
AND	transports	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (38)

Source	Relation	Type	Str
DZSM	regulates	drug	0.70
HDAC6	associated_with	gene	0.60
TP53	associated_with	gene	0.60
CCT2	associated_with	gene	0.60
GUSB	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
TNF	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ABCB1	regulates	gene	0.60
ACE	regulates	gene	0.60
CHAT	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
CYP2D6	regulates	gene	0.60
CYP3A4	regulates	gene	0.60
CYP3A5	regulates	gene	0.60
PPAR	transports	gene	0.60
DEMENTIA	transports	gene	0.60
GENES	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CHAT	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
ACE	transports	gene	0.60
POR	transports	gene	0.60
BCHE	transports	gene	0.60
CYP3A5	transports	gene	0.60
CHRNA7	therapeutic_target	gene	0.60
POR	therapeutic_target	gene	0.60
CYP3A5	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CHAT	therapeutic_target	gene	0.60
CYP3A4	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
CYP2D6	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
ACE	therapeutic_target	gene	0.60
CYP2C19	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NR1I2 in their description or question text

No additional research found