concept

AXON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1219Connections

12Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

AXON is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 388 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AXON
Key Genes/Proteins	ACHE, Actin, ADNP, AGING, AKT, Albumin
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

blarcamesine-axon

clinical_trial · 2860 words

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Pathway Diagram

graph TD
    AXON["AXON"]
    AXON -->|"causes"| ALS["ALS"]
    AXON -->|"activates"| Cancer["Cancer"]
    AXON -->|"causes"| Inflammation["Inflammation"]
    AXON -->|"causes"| Aging["Aging"]
    AXON -->|"activates"| Neuroinflammation["Neuroinflammation"]
    AXON -->|"stabilizes"| JUN["JUN"]
    AXON -->|"expressed in"| NEURON["NEURON"]
    CDK5["CDK5"] -->|"causes"| AXON
    CANCER["CANCER"] -->|"activates"| AXON
    HIPPO["HIPPO"] -->|"activates"| AXON
    G3BP1["G3BP1"] -->|"activates"| AXON
    NEURON -->|"activates"| AXON
    INFLAMMATION["INFLAMMATION"] -->|"causes"| AXON
    HSP90["HSP90"] -->|"activates"| AXON
    ROS["ROS"] -->|"activates"| AXON

Outgoing (763)

Target	Relation	Type	Str
Als	activates	disease	0.95
oligodendrocytes	found_in	cell_type	0.90
neural stem cells	found_in	cell_type	0.90
astrocytes	found_in	cell_type	0.90
neurons	found_in	cell_type	0.90
Neurodegeneration	causes	disease	0.85
Cancer	activates	disease	0.85
hippocampus	enriched_in	brain_region	0.80
unfolded protein response	involved_in	pathway	0.80
spinal cord	enriched_in	brain_region	0.80
microglia	found_in	cell_type	0.80
NEURON	activates	gene	0.80
NEURODEGENERATION	causes	gene	0.80
CANCER	activates	gene	0.80
NEURON	causes	gene	0.80
Amyotrophic Lateral Sclerosis	activates	disease	0.75
ALS	causes	disease	0.75
Inflammation	activates	disease	0.75
Alzheimer	activates	disease	0.75
Alzheimer	regulates	disease	0.75
Parkinson	regulates	disease	0.75
Als	regulates	disease	0.75
Tumor	activates	disease	0.75
Multiple Sclerosis	associated_with	disease	0.75
AXON REGENERATION	associated_with	gene	0.70
pyramidal neurons	found_in	cell_type	0.70
MICROGLIA	associated_with	gene	0.70
Schwann cells	found_in	cell_type	0.70
ASTROCYTES	activates	gene	0.70
ASTROCYTE	associated_with	gene	0.70
Oxidative Stress	activates	pathway	0.70
OXIDATIVE STRESS	activates	gene	0.70
Differentiation	regulates	pathway	0.70
ALZHEIMER	regulates	gene	0.70
INFLAMMATION	activates	gene	0.70
PARKINSON	regulates	gene	0.70
AXON REGENERATION	activates	gene	0.70
Mapk	activates	pathway	0.70
white matter	enriched_in	brain_region	0.70
DNA	activates	gene	0.70
Mtor	associated_with	pathway	0.70
MTOR	associated_with	gene	0.70
interneurons	found_in	cell_type	0.70
TRAK1	interacts_with	gene	0.70
AKT	regulates	gene	0.70
cortex	enriched_in	brain_region	0.70
macrophages	found_in	cell_type	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.70
ALZHEIMER	activates	gene	0.70

Incoming (456)

Source	Relation	Type	Str
TAU	expressed_in	entity	0.90
neurodegeneration	disrupts	disease	0.90
MAPT	expressed_in	protein	0.90
TRAK1	expressed_in	protein	0.90
MAP6	expressed_in	protein	0.80
aging	disrupts	disease	0.80
multiple sclerosis	disrupts	disease	0.80
neuroinflammation	disrupts	disease	0.80
autism	disrupts	disease	0.80
Alzheimer's disease	disrupts	disease	0.80
NAD	activates	gene	0.70
SARM1	activates	gene	0.70
ALS	disrupts	disease	0.70
ROS	activates	gene	0.70
BDNF	activates	gene	0.70
Parkinson's disease	disrupts	disease	0.70
BDNF	inhibits	gene	0.70
RNA	interacts_with	gene	0.70
spinal muscular atrophy	disrupts	disease	0.70
NAD	regulates	gene	0.70
PROGRANULIN	regulates	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
SOD1	inhibits	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NEURON	therapeutic_target	gene	0.60
TRAK1	expressed_in	gene	0.60
G3BP1	encodes	gene	0.60
CAMKII	regulates	gene	0.60
PCSK9	activates	gene	0.60
EGF	activates	gene	0.60
HIF	associated_with	gene	0.60
AXON REGENERATION	associated_with	gene	0.60
G3BP1	activates	gene	0.60
NEURON	activates	gene	0.60
INFLAMMATION	causes	gene	0.60
HSP90	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ROS	activates	gene	0.60
NEURON	expressed_in	gene	0.60
DYNACTIN	interacts_with	gene	0.60
TRAK1	interacts_with	gene	0.60
KRAS	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
CD8	associated_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
ASTROCYTE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
EPHB3	interacts_with	gene	0.60
CACNA1B	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
eIF2α Phosphorylation Imbalance Creates Integrated Stress Re	0.866	ALS	-
hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport F	0.834	ALS	-
GLE1-Mediated mRNA Export Defect Creates Translation-Compete	0.826	ALS	-
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.698	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.698	neurodegeneration	What is the molecular mechanism by which

Axonal RNA Transport Reconstitution	0.695	neurodegeneration	RNA binding protein dysregulation across
STMN2 Restoration as a Prerequisite for Axon Growth After TD	0.683	neurodegeneration	What molecular mechanisms enable functio
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
Axonal Transport Defect: C9orf72 hexanucleotide expansion im	0.660	neurodegeneration	What are the neuron-specific effects of
A genetically encoded reporter for axonal mitochondrial prot	0.565	neuroscience	How can subcellular compartmentalization
Synaptic-Selective Autophagy Receptor Expression to Bypass A	0.370	proteomics	Quantitative proteomics of the aging syn
Axonal Integrity Recovery Following Amyloid Clearance Drives	0.365	-	Can CSF p-tau217 normalization serve as

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Temporal analysis showing mitochondrial defects precede other p	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
ALS Regional Onset and Spread: Network-Level Staging Model	clinical	ALS	0.400	0.50	human	proposed	$7,500,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Environmental Exposure Causal Attribution in ALS — Experiment Design	validation	ALS	0.400	0.50	human	proposed	$3,000,000
Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966]	Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X	Theranostics	2023	1
Multisystem proteinopathy: Where myopathy and motor neuron disease converge. [PMID:33145792]	Korb MK, Kimonis VE, Mozaffar T	Muscle Nerve	2021	1
The role of m6A modification in the biological functions and diseases. [PMID:33611339]	Jiang X, Liu B, Nie Z, Duan L, Xiong Q,	Signal Transduct Target Ther	2021	1
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liv [PMID:33213490]	Senlin Zhao, Yushuai Mi, Bingjie Guan, B	Journal of hematology & oncolo	2020	1
Rare Inherited forms of Paget's Disease and Related Syndromes. [PMID:30756140]	Ralston SH, Taylor JP	Calcif Tissue Int	2019	1
A LNK-CBL-HNRPA2B1-GPX4 signaling axis mediates dopaminergic neuron vulnerabilit [PMID:41616574]	["Liu Z", "Wang R", "Shen M", "Lan X", "	Redox biology	2026	0
Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding pro [PMID:41725810]	["Cerasuolo A", "Pecchillo Cimmino T", "	Frontiers in microbiology	2026	0
Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-q [PMID:41888191]	["Shahatibieke D", "Tang X", "Zheng X",	Scientific reports	2026	0
LncRNA 4930544M13Rik-201 regulates CACNA2D1 expression via interacting with hnRN [PMID:41864512]	Fang Z, Liu F, Tang Q, Liu Y, Peng Y, Zh	Brain research bulletin	2026	0
Comparative Binding Analysis by Computational Methods and Quartz Crystal Microba [PMID:41728844]	["Volkova O", "Serova A", "Kravtsov V",	Journal of chemical informatio	2026	0
Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non-Syndro [PMID:41918261]	Guo S, Guo T, Xu Y, Chen R, Wang X	Orthodontics & craniofacial re	2026	0
Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 [PMID:41853685]	Zhou Z, Li Y, Yang P, Zhu R, Li J, Wu B,	Current research in structural	2026	0
Neddylation-Mediated hnRNPA2B1 Degradation Aggravates Retinal Endothelial Cell D [PMID:41773772]	Chen TR, Zhou JX, Hou YR, Zhang YN, Li C	Investigative ophthalmology &	2026	0
Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition o [PMID:41662154]	["Park R", "Demny M", "Miller L", "Pedra	RNA biology	2026	0
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP [PMID:41787499]	Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li	Journal of translational medic	2026	0
Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergi [PMID:41507195]	["Jin Y", "Cao Y", "Ma W", "Li R", "Li Y	Nature communications	2026	0
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatic [PMID:41725222]	["Xu W", "Shi L", "Lu A", "Cui L", "Qian	Immunity, inflammation and dis	2026	0
Expression, purification, and biophysical characterization of liquid-liquid phas [PMID:41297573]	["Dur\u00e1n-Armenta L", "Meszaros A", "	Protein expression and purific	2026	0
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progre [PMID:34453888]	Jiang L, Lin W, Zhang C, Ash PEA, Verma	Molecular cell	2021	0
Stress granule mediated protein aggregation and underlying gene defects in the F [PMID:31626953]	Baradaran-Heravi Y, Van Broeckhoven C, v	Neurobiology of disease	2020	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AXON in their description or question text

AXON

Understanding Entity Pages

Summary

Wiki Pages (1)

blarcamesine-axon

Pathway Diagram

Outgoing (763)

Incoming (456)

Targeting Hypotheses (12)

Mentioning Analyses (0)

Experiments (10)

Related Papers (20)

Debates (0)

Related Research

Axonal RNA Transport Reconstitution

STMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance

Stathmin-2 Splice Switching to Prevent Axonal Degeneration Across the ALS-FTD-AD

Axonal Transport Defect: C9orf72 hexanucleotide expansion impairs retrograde aut

A genetically encoded reporter for axonal mitochondrial protein import fidelity

Synaptic-Selective Autophagy Receptor Expression to Bypass Axonal Lysosome Defic

Axonal Integrity Recovery Following Amyloid Clearance Drives CSF p-tau217 Normal