concept

TRAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

1Hypotheses

0Analyses

50Outgoing

42Incoming

10Experiments

0Debates

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💡 Concept Info

Name	TRAK1
Key Genes/Proteins	Actin, Actr1A, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS
Related Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Related Pathways	Apoptosis, axonal mitochondrial motility
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    TRAK1["TRAK1"]
    TRAK1 -->|"activates"| Ischemia["Ischemia"]
    TRAK1 -->|"activates"| Ms["Ms"]
    TRAK1 -->|"activates"| Stroke["Stroke"]
    TRAK1 -->|"activates"| Hypertension["Hypertension"]
    TRAK1 -->|"activates"| Als["Als"]
    TRAK1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TRAK1 -->|"activates"| Glaucoma["Glaucoma"]
    TRAK1 -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TRAK1 -->|"regulates"| MIRO1["MIRO1"]
    TRAK1 -->|"activates"| Apoptosis["Apoptosis"]
    OPTN["OPTN"] -->|"binds"| TRAK1
    MIRO1 -->|"binds"| TRAK1
    MITOCHONDRIA["MITOCHONDRIA"] -->|"interacts"| TRAK1
    AXON["AXON"] -->|"interacts"| TRAK1
    KIF5B["KIF5B"] -->|"regulates"| TRAK1
    ASTROCYTES["ASTROCYTES"] -->|"activates"| TRAK1
    CD38["CD38"] -->|"regulates"| TRAK1
    APOPTOSIS["APOPTOSIS"] -->|"activates"| TRAK1
    NEURON["NEURON"] -->|"interacts"| TRAK1

Outgoing (76)

Target	Relation	Type	Str
mitochondrial trafficking	mediates	process	0.95
Dynein	binds	protein	0.95
Mitochondrial Trafficking	regulates	process	0.95
Axonal Mitochondrial Transport	mediates	process	0.90
Axon	expressed_in	cell_type	0.90
Dynein/Dynactin Complex	binds	protein	0.90
KIF5B	binds	protein	0.90
Actr1A	binds	protein	0.90
axon outgrowth	associated_with	phenotype	0.90
mitochondria	binds	cell_type	0.90
KIF5B	interacts_with	protein	0.90
KIF5A	associated_with	protein	0.85
Cargo Transport	involved_in	process	0.85
Axonal Outgrowth	regulates	phenotype	0.85
TRAK2	associated_with	protein	0.75
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Glaucoma	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Hypertension	activates	disease	0.65
Als	activates	disease	0.65
Raf	interacts_with	protein	0.60
AXON	interacts_with	gene	0.60
AXON REGENERATION	activates	gene	0.60
MIRO1	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
NEURON	transports	gene	0.60
AND	associated_with	gene	0.60
ALS	activates	gene	0.60
mitochondria	interacts_with	cell_type	0.60
axonal mitochondrial motility	involved_in	pathway	0.60
axons	expressed_in	brain_region	0.60
Raf	transports	protein	0.60
MITOCHONDRIA	transports	gene	0.60
DYNACTIN	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
Axonal Transport	transports	pathway	0.60
KIF5C	associated_with	gene	0.60
OPTN	activates	gene	0.60
neurodegeneration	activates	disease	0.60
KIF5A	regulates	gene	0.60
AND	regulates	gene	0.60
AND	interacts_with	gene	0.60
NORMAL TENSION GLAUCOMA	activates	gene	0.60
Neuron	interacts_with	cell_type	0.60
MITOCHONDRIA	associated_with	gene	0.60
Kinesin	regulates	protein	0.60

Incoming (42)

Source	Relation	Type	Str
OPTN	interacts_with	protein	0.95
MIRO1	binds	protein	0.90
OPTN	binds	gene	0.90
MITOCHONDRIA	interacts_with	gene	0.70
AXON	interacts_with	gene	0.70
NEURON	interacts_with	gene	0.60
NEURON	transports	gene	0.60
AND	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
AXON REGENERATION	activates	gene	0.60
KIF5A	regulates	gene	0.60
AND	regulates	gene	0.60
DYNEIN	interacts_with	gene	0.60
MITOCHONDRIA	transports	gene	0.60
AND	interacts_with	gene	0.60
KIF5A	associated_with	gene	0.60
DYNACTIN	interacts_with	gene	0.60
KIF5C	associated_with	gene	0.60
GLAUCOMA	activates	gene	0.60
KIF5B	regulates	gene	0.60
ASTROCYTES	activates	gene	0.60
CD38	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
NORMAL TENSION GLAUCOMA	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
KIF5B	activates	gene	0.60
ALS	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	interacts_with	gene	0.60
OPTN	activates	gene	0.60
KIF5A	activates	gene	0.55
KIF5A	interacts_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
AXON	associated_with	concept	0.50
KINESIN-1	interacts_with	protein	0.50
KIF5C	interacts_with	protein	0.50
Neurodegeneration	activates	disease	0.50
Hypertension	activates	disease	0.50
MIRO1	interacts_with	protein	0.50
KIF5B	interacts_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.621	neurodegeneration	Mitochondrial transfer between astrocyte

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
AAV-LRRK2 IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
AAV-LRRK2 Gene Therapy IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson'	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745]	Rydzanicz M, Jagła M, Kosinska J, Tomasi	Clin Genet	2017	1
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375]	van Spronsen M, Mikhaylova M, Lipka J, S	Neuron	2013	1
Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670]	Randall TS, Moores C, Stephenson FA	FEBS Lett	2013	1
Therapeutic developments in pancreatic cancer. [PMID:37798442]	["Hu Z", "O'Reilly E"]	Nature reviews. Gastroenterolo	2024	0
Defining treatment-resistant depression. [PMID:31638723]	["Gaynes B", "Lux L", "Gartlehner G", "A	Depression and anxiety	2020	0
Emerging trends in global freshwater availability. [PMID:29769728]	["Rodell M", "Famiglietti J", "Wiese D",	Nature	2018	0
Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969]	["Kurmani S", "Squire I"]	Current heart failure reports	2017	0
Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335]	["Aquino R", "Vasques P", "Cavalcante D"	Revista do Colegio Brasileiro	2017	0
The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062]	["Kane J", "Johnson R", "Robinson C", "J	The Journal of adolescent heal	2016	0
A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607]	["Naqvi N", "Li M", "Calvert J", "Tejada	Cell	2014	0
Family medicine match rate increases slightly. [PMID:22585896]	Sheri Porter	Annals of family medicine	2012	0
Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899]	["Pivac N", "Knezevi\u0107 A", "Gornik O	Molecular & cellular proteomic	2011	0
The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503]	["Bulgakova N", "Knust E"]	Journal of cell science	2009	0
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423]	["Landsman L", "Bar-On L", "Zernecke A",	Blood	2009	0
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324]	Brickley K, Smith MJ, Beck M, Stephenson	The Journal of biological chem	2005	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRAK1 in their description or question text

No additional research found