protein

SARM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SARM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

123Connections

2Hypotheses

0Analyses

50Outgoing

30Incoming

0Experiments

0Debates

Summary

SARM1 is a protein involved in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Alzheimer's disease, Cancer. Connected to 29 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SARM1
Primary Expression	hippocampus
Subcellular Localization	Axonal mitochondria-associated; activated by rising NMN:NAD+ ratio upon mitochondrial stress
Molecular Weight	89.5 kDa
Pathways	Disease Progression, Neuroinflammation
GeneCards	SARM1
Human Protein Atlas	SARM1
Primary Target	SARM1 NADase catalytic domain (TIR domain)
Target Type	Small-molecule allosteric inhibitor or NAD+ competitive inhibitor
Associated Diseases	Als, Alzheimer's disease, Memory Impairment, neurodegeneration, traumatic brain injury
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, AUTOPHAGY, AXON
KG Connections	123 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SARM1["SARM1"]
    axonal_degeneration(["axonal degeneration"])
    SARM1 -->|"activates"| axonal_degeneration
    neuroinflammation(["neuroinflammation"])
    SARM1 -->|"regulates"| neuroinflammation
    Alzheimer_s_disease{"Alzheimer's disease"}
    SARM1 -->|"associated with"| Alzheimer_s_disease
    hippocampal_neurons["hippocampal neurons"]
    SARM1 -->|"expressed in"| hippocampal_neurons
    Ms{"Ms"}
    SARM1 -->|"activates"| Ms
    AND["AND"]
    SARM1 -->|"activates"| AND
    DLK["DLK"]
    SARM1 -->|"activates"| DLK
    PUMA["PUMA"]
    SARM1 -->|"activates"| PUMA
    Apoptosis(["Apoptosis"])
    SARM1 -->|"activates"| Apoptosis
    Mapk(["Mapk"])
    SARM1 -->|"activates"| Mapk
    TNF["TNF"]
    TNF -->|"inhibits"| SARM1
    NAD["NAD"]
    NAD -->|"activates"| SARM1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| SARM1
    AXON["AXON"]
    AXON -->|"activates"| SARM1
    BAX["BAX"]
    BAX -->|"activates"| SARM1
    style SARM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (93)

Target	Relation	Type	Str
Jnk/Sting/Tbk1 Pathway	regulates	pathway	0.95
Depressive-Like Behavior	promotes	phenotype	0.95
BDNF	regulates	protein	0.90
Neurodegeneration	associated_with	process	0.90
Axonal Degeneration	associated_with	process	0.90
Hippocampal Neurons	expressed_in	cell_type	0.85
Neuroinflammation	involved_in	process	0.85
Central Nervous System	expressed_in	cell_type	0.80
Alzheimer's Disease	associated_with	disease	0.80
Memory Impairment	associated_with	phenotype	0.80
Neurodegeneration	mediates	process	0.80
Disease Progression	involved_in	process	0.75
AXON	activates	gene	0.70
axonal degeneration	activates	process	0.70
neuroinflammation	regulates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
hippocampal neurons	expressed_in	cell_type	0.70
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
Neuropathy	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Tumor	activates	disease	0.65
Glioma	therapeutic_target	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Stroke	activates	disease	0.65
APOPTOSIS	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
GBM	activates	gene	0.60
STROKE	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
Autophagy	activates	pathway	0.60
hippocampus	expressed_in	brain_region	0.60
Tumor Microenvironment	therapeutic_target	pathway	0.60
BRAIN INJURY	associated_with	gene	0.60
NEURON	activates	gene	0.60
Stem Cell	activates	pathway	0.60
Neuron	inhibits	cell_type	0.60
neuroinflammation	activates	disease	0.60
neurons	expressed_in	cell_type	0.60
neurodegeneration	implicated_in	disease	0.60
STING	activates	gene	0.60

Incoming (30)

Source	Relation	Type	Str
TNF	inhibits	entity	0.80
NAD	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AXON	activates	gene	0.60
BAX	activates	gene	0.60
CD68	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
DLK	regulates	gene	0.60
DLK	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
NAD	inhibits	gene	0.60
AXON	inhibits	gene	0.60
ROS	inhibits	gene	0.60
MAPK	activates	gene	0.60
BDNF	activates	gene	0.60
PSD95	activates	gene	0.60
NLRP3	inhibits	gene	0.60
PSD95	inhibits	gene	0.60
JNK	inhibits	gene	0.60
JNK	interacts_with	gene	0.60
NMNAT2	activates	gene	0.60
RNA	activates	gene	0.60
C3	activates	gene	0.60
C6	activates	gene	0.60
Neurodegeneration	activates	disease	0.50
Neuroinflammation	activates	process	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.698	neurodegeneration	What is the molecular mechanism by which
NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitopha	0.578	neurodegeneration	How do different organelle-specific auto

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SARM1 in their description or question text

No additional research found