P2X7

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2X7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

P2X7 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 71 entities in the SciDEX knowledge graph.

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graph TD
    P2X7["P2X7"]
    Als{"Als"}
    P2X7 -->|"associated with"| Als
    Ms{"Ms"}
    P2X7 -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    P2X7 -->|"associated with"| Diabetes
    Aging{"Aging"}
    P2X7 -->|"expressed in"| Aging
    P2X7 -->|"activates"| Ms
    Depression{"Depression"}
    P2X7 -->|"contributes to"| Depression
    Anxiety{"Anxiety"}
    P2X7 -->|"activates"| Anxiety
    P2X7 -->|"expressed in"| Als
    P2X7 -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    P2X7 -->|"regulates"| Inflammation
    Multiple_Sclerosis{"Multiple Sclerosis"}
    P2X7 -->|"activates"| Multiple_Sclerosis
    P2X7 -->|"activates"| Als
    P2RY1["P2RY1"]
    P2RY1 -->|"associated with"| P2X7
    P2RX7["P2RX7"]
    P2RX7 -->|"activates"| P2X7
    NLRP3["NLRP3"]
    NLRP3 -->|"expressed in"| P2X7
    PANX1["PANX1"]
    PANX1 -->|"activates"| P2X7
    P2RX4["P2RX4"]
    P2RX4 -->|"associated with"| P2X7
    P2RX7 -->|"associated with"| P2X7
    VDAC1["VDAC1"]
    VDAC1 -->|"activates"| P2X7
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"contributes to"| P2X7
    AQP4["AQP4"]
    AQP4 -->|"activates"| P2X7
    BRAIN_INJURY["BRAIN INJURY"]
    BRAIN_INJURY -->|"inhibits"| P2X7
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| P2X7
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"associated with"| P2X7
    style P2X7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0