CSPG4

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSPG4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

CSPG4 (NG2) - Cell surface proteoglycan on pericytes, critical for blood-brain barrier integrity and neurovascular function in neurodegeneration

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flowchart TD
    N0["CSPG4"]
    N1["ALS"]
    N0 -->|"interacts with"| N1
    N2["Inflammation"]
    N0 -->|"interacts with"| N2
    N3["AXON"]
    N0 -->|"regulates"| N3
    N4["AND"]
    N0 -->|"regulates"| N4
    N5["ASTROCYTES"]
    N0 -->|"regulates"| N5
    N6["NOTCH"]
    N0 -->|"interacts with"| N6
    N7["HSPG2"]
    N0 -->|"interacts with"| N7
    N8["Notch"]
    N0 -->|"interacts with"| N8
    N9["INFLAMMATION"]
    N9 -->|"interacts with"| N0
    N10["PROGRANULIN"]
    N10 -->|"interacts with"| N0
    N11["BRAIN INJURY"]
    N11 -->|"interacts with"| N0
    N12["Astrocyte"]
    N0 -->|"expressed in"| N12
    N13["Neuron"]
    N0 -->|"expressed in"| N13
    N0 -->|"associated with"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 pathway
    class N9 gene
    class N10 gene
    class N11 gene

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