gene

PAFAH1B1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAFAH1B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

32Outgoing

16Incoming

0Experiments

0Debates

Summary

Page for PAFAH1B1 — Platelet Activating Factor Acetylhydrolase 1B Subunit 1

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🧬 Gene Info

Gene Symbol	PAFAH1B1
Full Name	Platelet Activating Factor Acetylhydrolase 1B Subunit 1
Chromosome	17p13.3
Protein Type	Hydrolase
Function	is a gene located on chromosome 17p13.
Primary Expression	Ubiquitously expressed; high expression in brain, particularly neurons
Amino Acids	410 aa
Exons	11
Pathways	Nucleokinesis
UniProt ID	P43004
NCBI Gene ID	5099
Ensembl ID	ENSG00000007174
OMIM	601545
GeneCards	PAFAH1B1
Human Protein Atlas	PAFAH1B1
Associated Diseases	Als, Lissencephaly Type 1, Type 1 Lissencephaly
Interactions	CDK5, DAB1, NDEL1, NLRP3, RAGE, TFEB
KG Connections	48 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PAFAH1B1 — AlphaFold P43004 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PAFAH1B1 — Platelet Activating Factor Acetylhydrolase 1B Subunit 1

gene · 738 words

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Pathway Diagram

graph TD
    PAFAH1B1["PAFAH1B1"]
    Ms{"Ms"}
    PAFAH1B1 -->|"interacts with"| Ms
    Als{"Als"}
    PAFAH1B1 -->|"interacts with"| Als
    PAFAH1B1 -->|"associated with"| Als
    ALS{"ALS"}
    PAFAH1B1 -->|"causes"| ALS
    DAB1["DAB1"]
    PAFAH1B1 -->|"interacts with"| DAB1
    DCX["DCX"]
    PAFAH1B1 -->|"associated with"| DCX
    LIS1["LIS1"]
    PAFAH1B1 -->|"associated with"| LIS1
    CDK5["CDK5"]
    PAFAH1B1 -->|"interacts with"| CDK5
    PAFAH1B1 -->|"causes"| DAB1
    REELIN["REELIN"]
    PAFAH1B1 -->|"causes"| REELIN
    Neuron["Neuron"]
    PAFAH1B1 -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    PAFAH1B1 -->|"implicated in"| neurodegeneration
    DCX -->|"associated with"| PAFAH1B1
    CDK5 -->|"interacts with"| PAFAH1B1
    LIS1 -->|"associated with"| PAFAH1B1
    DAB1 -->|"interacts with"| PAFAH1B1
    CDK5 -->|"associated with"| PAFAH1B1
    DAB1 -->|"associated with"| PAFAH1B1
    CDK5 -->|"causes"| PAFAH1B1
    AXON["AXON"]
    AXON -->|"causes"| PAFAH1B1
    LIS1 -->|"causes"| PAFAH1B1
    NEURON["NEURON"]
    NEURON -->|"causes"| PAFAH1B1
    DCX -->|"causes"| PAFAH1B1
    DYNEIN["DYNEIN"]
    DYNEIN -->|"causes"| PAFAH1B1
    style PAFAH1B1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
Lissencephaly Type 1	causes	disease	0.95
nucleokinesis	regulates	process	0.90
Nucleokinesis	involved_in	process	0.90
Type 1 Lissencephaly	causes	disease	0.85
Microtubules	interacts_with	compound	0.85
NDEL1	interacts_with	protein	0.80
ALS	causes	disease	0.65
Als	causes	disease	0.65
Als	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
DYNEIN	causes	gene	0.60
Actin	causes	protein	0.60
Dynein	causes	protein	0.60
DCX	causes	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
RAGE	activates	gene	0.60
TFEB	activates	gene	0.60
neuroinflammation	activates	disease	0.60
RAGE	regulates	gene	0.60
DAB1	interacts_with	gene	0.60
DCX	associated_with	gene	0.60
LIS1	associated_with	gene	0.60
CDK5	interacts_with	gene	0.60
REELIN	causes	gene	0.60
Cdk5	causes	protein	0.60
DAB1	causes	gene	0.60
Neuron	causes	cell_type	0.60
AXON	causes	gene	0.60
Neuron	expressed_in	cell_type	0.55
LIS1	causes	protein	0.50

Incoming (16)

Source	Relation	Type	Str
DYNEIN	causes	gene	0.60
CDK5	associated_with	gene	0.60
DAB1	associated_with	gene	0.60
CDK5	causes	gene	0.60
NLRP3	activates	gene	0.60
DCX	associated_with	gene	0.60
CDK5	interacts_with	gene	0.60
LIS1	associated_with	gene	0.60
DAB1	interacts_with	gene	0.60
REELIN	causes	gene	0.60
DAB1	causes	gene	0.60
AXON	causes	gene	0.60
NEURON	causes	gene	0.60
MICROTUBULES	causes	gene	0.60
LIS1	causes	gene	0.60
DCX	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PAFAH1B1 in their description or question text

No additional research found