concept

AUTOPHAGY-RELATED GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGY-RELATED GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

389Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AUTOPHAGY-RELATED GENES is a concept in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Als, Alzheimer, Atherosclerosis. Connected to 309 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AUTOPHAGY-RELATED GENES
Key Genes/Proteins	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1, AMPK, AND
Related Diseases	Als, ALS, Alzheimer
Related Pathways	Akt, Apoptosis

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Autophagy-Related Genes

gene · 812 words

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Pathway Diagram

graph TD
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    AUTOPHAGY_RELATED_GENES -->|"regulates"| autophagy["autophagy"]
    AUTOPHAGY_RELATED_GENES -->|"activates"| Als["Als"]
    AUTOPHAGY_RELATED_GENES -->|"activates"| Parkinson["Parkinson"]
    AUTOPHAGY_RELATED_GENES -->|"activates"| Neuroinflammation["Neuroinflammation"]
    AUTOPHAGY_RELATED_GENES -->|"activates"| Inflammation["Inflammation"]
    AUTOPHAGY_RELATED_GENES -->|"regulates"| Ms["Ms"]
    MTOR["MTOR"] -->|"activates"| AUTOPHAGY_RELATED_GENES
    PI3K["PI3K"] -->|"activates"| AUTOPHAGY_RELATED_GENES
    AKT["AKT"] -->|"activates"| AUTOPHAGY_RELATED_GENES
    SOX9["SOX9"] -->|"activates"| AUTOPHAGY_RELATED_GENES
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| AUTOPHAGY_RELATED_GENES
    MICROGLIA["MICROGLIA"] -->|"regulates"| AUTOPHAGY_RELATED_GENES
    P62["P62"] -->|"activates"| AUTOPHAGY_RELATED_GENES
    ULK1["ULK1"] -->|"regulates"| AUTOPHAGY_RELATED_GENES

Outgoing (215)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:AUTOPHAGY-RELATED GENES	data_in	dataset_row	0.00
Autophagy	associated_with	pathway	1.00
GENES	associated_with	gene	1.00
Autophagy	regulates	pathway	1.00
AUTOPHAGY	associated_with	gene	1.00
GENES	regulates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
Intestinal Disease	associated_with	disease	0.90
Neurodevelopmental Disorders	associated_with	disease	0.88
Intestinal Epithelial Maintenance	contributes_to	phenotype	0.85
Als	regulates	disease	0.85
intestinal disease	associated_with	disease	0.80
Cancer	therapeutic_target	disease	0.75
Inflammation	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Inflammation	regulates	disease	0.75
Hepatitis	therapeutic_target	disease	0.75
Als	activates	disease	0.75
INFLAMMATION	regulates	gene	0.70
autophagy	regulates	process	0.70
CANCER	regulates	gene	0.70
Autophagy	activates	pathway	0.70
Apoptosis	associated_with	pathway	0.70
Heart Failure	associated_with	disease	0.65
Cardiac	associated_with	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Longevity	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Infection	regulates	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Cardiac	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Ischemia	activates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Sepsis	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiovascular	regulates	disease	0.65

Incoming (174)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:AUTOPHAGY-RELATED GENES	data_in	dataset_row	0.00
autophagy-related-genes	describes	wiki	0.90
CHROMATINOPATHY GENES	regulates	gene	0.82
trehalose	upregulates	compound	0.80
APOPTOSIS	associated_with	gene	0.70
MIRNAS	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
BECLIN1	associated_with	gene	0.60
PI3K	activates	gene	0.60
P62	associated_with	gene	0.60
AKT	activates	gene	0.60
SOX9	activates	gene	0.60
PIK3C3	activates	gene	0.60
MAPK14	associated_with	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
UVRAG	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
GABARAPL2	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
ATG7	associated_with	gene	0.60
STING	activates	gene	0.60
ATG5	associated_with	gene	0.60
CGAS	activates	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
FAS	expressed_in	gene	0.60
RELA	associated_with	gene	0.60
ATF6	expressed_in	gene	0.60
CFLAR	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
VEGFA	expressed_in	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ERK1	activates	gene	0.60
DNA	regulates	gene	0.60
EPILEPSY	associated_with	gene	0.60
MTOR	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
P62	activates	gene	0.60
ULK1	regulates	gene	0.60
SQSTM1	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
STAT1	activates	gene	0.60
LC3B	inhibits	gene	0.60
ATG5	regulates	gene	0.60
GABARAP	regulates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AUTOPHAGY-RELATED GENES in their description or question text

No additional research found