gene

ULK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ULK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ULK2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with ALS, Als, Inflammation. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ULK2
Full Name	Unc-51 Like Kinase 2
Chromosome	17p11.2
Function	ULK2 orchestrates autophagy initiation through a sophisticated cascade of protein interactions and phosphorylation events
Primary Expression	both excitatory and inhibitory neurons
Molecular Weight	105 kDa
Pathways	mTOR, mtor, AMPK, PI3K
UniProt ID	[Q8IYT8](https://www.uniprot.org/uniprot/Q8IYT8)
Ensembl ID	ENSG00000107485
GeneCards	ULK2
Human Protein Atlas	ULK2
[mTOR](/entities/mtor) sensing	ULK2 is inhibited by mTORC1 under nutrient-rich conditions; mTORC1 phosphorylates ULK2 at multiple sites to suppress autophagy initiation[@egan2011]
AMPK activation	Energy stress activates AMPK, which directly phosphorylates ULK2 at Ser317 and Ser777 to stimulate autophagy[@gwinn2008]
Phosphorylation targets	ULK2 phosphorylates multiple autophagy proteins including Beclin-1, Vps34, and ATG14 to promote autophagosome nucleation[@russell2013]
Neuronal autophagy	Critical for neuronal protein quality control, clearing misfolded proteins and damaged organelles[@button2014]
Associated Diseases	Als, Alzheimer, Inflammation
Interactions	ALZHEIMER, AMPK, APOE, APP, CALB1, CCT4
KG Connections	111 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ULK2 Gene

gene · 1088 words

→

ULK2 Protein

protein · 880 words

→

Pathway Diagram

graph TD
    ULK2["ULK2"]
    autophagy(["autophagy"])
    ULK2 -->|"regulates"| autophagy
    Als{"Als"}
    ULK2 -->|"activates"| Als
    Inflammation{"Inflammation"}
    ULK2 -->|"associated with"| Inflammation
    ALS{"ALS"}
    ULK2 -->|"activates"| ALS
    ULK1["ULK1"]
    ULK2 -->|"associated with"| ULK1
    Mitophagy(["Mitophagy"])
    ULK2 -->|"activates"| Mitophagy
    Autophagy(["Autophagy"])
    ULK2 -->|"associated with"| Autophagy
    GABARAPL2["GABARAPL2"]
    ULK2 -->|"associated with"| GABARAPL2
    INFLAMMATION["INFLAMMATION"]
    ULK2 -->|"associated with"| INFLAMMATION
    BECN1["BECN1"]
    ULK2 -->|"associated with"| BECN1
    AUTOPHAGY["AUTOPHAGY"]
    ULK2 -->|"associated with"| AUTOPHAGY
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    ULK2 -->|"associated with"| AUTOPHAGY_RELATED_GENES
    E2F4["E2F4"]
    E2F4 -->|"regulates"| ULK2
    AMPK["AMPK"]
    AMPK -->|"activates"| ULK2
    ATG1["ATG1"]
    ATG1 -->|"associated with"| ULK2
    ULK1 -->|"associated with"| ULK2
    P62["P62"]
    P62 -->|"activates"| ULK2
    AMPK -->|"associated with"| ULK2
    UVRAG["UVRAG"]
    UVRAG -->|"associated with"| ULK2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| ULK2
    AND["AND"]
    AND -->|"associated with"| ULK2
    AUTOPHAGY -->|"associated with"| ULK2
    style ULK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
autophagy	regulates	pathway	0.90
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65
Als	activates	disease	0.65
Inflammation	regulates	disease	0.65
PRDX3	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
Innate Immunity	regulates	pathway	0.60
AND	associated_with	gene	0.60
T Cell	activates	cell_type	0.60
COPA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
APP	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
Mitophagy	activates	pathway	0.60
Autophagy	associated_with	pathway	0.60
INFLAMMATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
Igf	associated_with	protein	0.60
autophagy pathway	participates_in	pathway	0.60
Alzheimer's disease	interacts_with	disease	0.60
Autophagy	regulates	pathway	0.60
ULK1	associated_with	gene	0.60
GABARAPL2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
P62	activates	gene	0.60
ATG1	associated_with	gene	0.60
MAP1LC3B	regulates	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
IDS	associated_with	gene	0.60
T Cell	expressed_in	cell_type	0.55
IGF2R	interacts_with	protein	0.50
SYNCRIP	interacts_with	concept	0.50

Incoming (55)

Source	Relation	Type	Str
E2F4	regulates	protein	0.90
AMPK	phosphorylates	protein	0.85
AMPK	activates	protein	0.64
COPA	interacts_with	gene	0.60
ATG1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
P62	activates	gene	0.60
UVRAG	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
COPA	associated_with	gene	0.60
AMPK	targets	gene	0.60
AMPK	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
GENES	regulates	gene	0.60
PROINFLAMMATORY CYTOKINES	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AND	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
ULK1	targets	gene	0.60
APP	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
STXBP3	interacts_with	gene	0.60
SYNCRIP	interacts_with	gene	0.60
SYNE2	interacts_with	gene	0.50
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50
PRDX3	interacts_with	gene	0.50
SSBP1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ULK2 in their description or question text

No additional research found