gene

DVL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DVL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

8Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for DVL3 — Dishevelled Segment Polarity Protein 3

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🧬 Gene Info

Gene Symbol	DVL3
Full Name	Dishevelled Segment Polarity Protein 3
Chromosome	3q27.1
Function	Wnt signaling: Transduces both canonical and non-canonical Wnt signals
Molecular Weight	82 kDa
Amino Acids	740 aa
Pathways	Wnt signaling, wnt, Wnt
GeneCards	DVL3
Human Protein Atlas	DVL3
Neuronal migration	DVL3-mediated PCP signaling controls radial migration of cortical neurons during corticogenesis
Axon guidance	The DVL3-DAAM1-RHOA axis regulates growth cone dynamics and axonal pathfinding
Dendritic arborization	PCP signaling influences dendritic branching and spine morphogenesis
Ciliary basal body positioning	DVL3 localizes to the basal body and regulates ciliary placement during neural tube development
Radial migration	DVL3 regulates the transition of neurons from the ventricular zone to the cortical plate
Multipolar migration	DVL3-mediated PCP signaling controls the morphodynamic changes of migrating neurons
Associated Diseases	neurodegeneration
Interactions	MEX3A
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DVL3 — Dishevelled Segment Polarity Protein 3

gene · 2849 words

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Pathway Diagram

graph TD
    DVL3["DVL3"]
    Als{"Als"}
    DVL3 -->|"expressed in"| Als
    Anxiety{"Anxiety"}
    DVL3 -->|"expressed in"| Anxiety
    Depression{"Depression"}
    DVL3 -->|"expressed in"| Depression
    Complement(["Complement"])
    DVL3 -->|"expressed in"| Complement
    neurodegeneration["neurodegeneration"]
    DVL3 -->|"implicated in"| neurodegeneration
    IL_6["IL-6"]
    IL_6 -->|"expressed in"| DVL3
    style DVL3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
WNT	regulates	pathway	0.85
Cancer Stem-Like Cells	associated_with	cell_type	0.80
Wnt/β-catenin/c-Myc/SOX2	activates	pathway	0.80
EMT	associated_with	biological_process	0.80
Anxiety	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Complement	expressed_in	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
MEX3A	interacts_with	gene	0.80
IL-6	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DVL3 in their description or question text

No additional research found