gene 3,328 words KG: WNT4
Contents

WNT4 Gene

🧬 Gene Info
Gene SymbolWNT4
Chromosome1p36.23
Protein TypeGene
Functionis a member of the Wnt family of secreted lipid-modified signaling proteins that play critical roles in development, tissue homeostasis, and disease processes.
Primary Expressionvarious brain regions and regulates neural stem cell maintenance, neuronal differentiation, synapse formation, and neuroprotection
Amino Acids351 aa
Exons4
PathwaysWNT, Wnt, Wnt signaling
UniProt IDP56705
NCBI Gene ID7498
Ensembl IDENSG00000163359
GeneCardsWNT4
Human Protein AtlasWNT4
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsCDK1, EGFR, ERBB2, FOXO1, GENES, GNB4
KG Connections28 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Transcriptional Autophagy-Lysosome Coupling
Score: 0.90
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

blarcamesine-axon
clinical_trial · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in
Genes
index · KG edge: activates
CDK1 — Cyclin-Dependent Kinase 1
gene · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

HSP90B1 activates WNT4
PI3K regulates WNT4
EGFR activates WNT4
HSPA4 activates WNT4
FOXO1 activates WNT4
HSP90AA1 activates WNT4
PRKACB activates WNT4
PIK3R1 activates WNT4
IGF1 activates WNT4
CDK1 activates WNT4

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