protein

GSK-3Β

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK-3Β: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

140Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

GSK-3β protein - major tau kinase in Alzheimer's disease, Wnt signaling

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🔬 Protein Info

Gene Symbol	GSK
Full Name	3β: Comprehensive Scientific Overview
Function	Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase originally identified for its role in glycogen metabolism.
GeneCards	GSK
Human Protein Atlas	GSK
Associated Diseases	ALS, Alzheimer, Neurodegeneration, Tumor
Interactions	AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND
KG Connections	119 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GSK-3β

entity · 994 words

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Pathway Diagram

graph TD
    GSK_3_(["GSK-3Beta"])
    __catenin["beta-catenin"]
    Neurodegeneration["Neurodegeneration"]
    Alzheimer["Alzheimer"]
    ALS["ALS"]
    JNK["JNK"]
    PI3K["PI3K"]
    Autophagy["Autophagy"]
    Amyloid["Amyloid"]
    Mtor["Mtor"]
    Pi3K_Akt["Pi3K/Akt"]
    Cell_Cycle["Cell Cycle"]
    Apoptosis["Apoptosis"]
    Jak_Stat["Jak-Stat"]
    NEURODEGENERATION["NEURODEGENERATION"]
    RAS["RAS"]
    ERK["ERK"]
    JAK["JAK"]
    AMYLOID["AMYLOID"]
    BID["BID"]
    BCL_2["BCL-2"]
    GSK_3_ -->|"phosphorylates"| __catenin
    GSK_3_ -->|"causes"| Neurodegeneration
    GSK_3_ -->|"causes"| Alzheimer
    GSK_3_ -->|"causes"| ALS
    GSK_3_ <-->|"interacts"| JNK
    GSK_3_ <-->|"interacts"| PI3K
    GSK_3_ -->|"causes"| Autophagy
    GSK_3_ -->|"causes"| Amyloid
    GSK_3_ <-->|"interacts"| Mtor
    GSK_3_ <-->|"interacts"| Pi3K_Akt
    GSK_3_ -->|"causes"| Cell_Cycle
    GSK_3_ -->|"activates"| Apoptosis
    GSK_3_ -->|"causes"| Jak_Stat
    NEURODEGENERATION -->|"causes"| GSK_3_
    RAS <-->|"interacts"| GSK_3_
    ERK <-->|"interacts"| GSK_3_
    JAK -->|"causes"| GSK_3_
    AMYLOID -->|"causes"| GSK_3_
    BID -->|"causes"| GSK_3_
    BCL_2 -->|"causes"| GSK_3_
    style GSK_3_ fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (76)

Target	Relation	Type	Str
tau	phosphorylates	protein	0.95
Tau	phosphorylates	protein	0.95
Alzheimer's_disease	activates	disease	0.90
Tau Hyperphosphorylation	activates	phenotype	0.90
CREB	upstream_of	protein	0.88
β-catenin	phosphorylates	protein	0.85
Tau Phosphorylation	involved_in	process	0.85
neurofibrillary tangle	promotes	phenotype	0.82
Pro-apoptotic Factors	activates	protein	0.80
apoptosis	activates	process	0.70
MAPT	regulates	protein	0.70
Alzheimer's_disease	associated_with	disease	0.70
Alzheimer	activates	disease	0.65
Alzheimer	causes	disease	0.65
Neurodegeneration	activates	disease	0.65
Depression	activates	disease	0.65
ALS	activates	disease	0.65
ALS	causes	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Neurodegeneration	causes	disease	0.65
Carcinoma	inhibits	disease	0.65
CDK5	activates	gene	0.60
Long-Term Potentiation	activates	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
CREB	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
Autophagy	causes	pathway	0.60
Amyloid	causes	pathway	0.60
Mtor	interacts_with	pathway	0.60
Pi3K/Akt	interacts_with	pathway	0.60
Cell Cycle	causes	pathway	0.60
Apoptosis	activates	pathway	0.60
Jak-Stat	causes	pathway	0.60
TAU	causes	gene	0.60
BAD	causes	gene	0.60
AMYLOID	causes	gene	0.60
JNK	interacts_with	gene	0.60
Tgf-Β	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
MTOR	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
BID	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
BCL-2	causes	gene	0.60
ERK	interacts_with	gene	0.60
ALZHEIMER	causes	gene	0.60
RAS	interacts_with	gene	0.60
BAX	causes	gene	0.60

Incoming (64)

Source	Relation	Type	Str
miR-219-5p	downregulates	biomarker	0.95
AKT	inhibits	protein	0.95
14-3-3ζ	interacts_with	protein	0.92
TAU	associated_with	gene	0.90
PKR	activates	gene	0.90
GLP-1R	inhibits	protein	0.88
AKT	interacts_with	protein	0.85
Lithium	inhibits	gene	0.80
WNT	regulates	gene	0.70
oxidative stress	increases	process	0.70
IL-1β	activates	protein	0.70
BCL-2	causes	gene	0.60
BAX	causes	gene	0.60
BAD	causes	gene	0.60
AKT	interacts_with	gene	0.60
BDNF	interacts_with	gene	0.60
AUTOPHAGY	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
AMYLOID	causes	gene	0.60
CREB	interacts_with	gene	0.60
TAU	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
TRKB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
SPR	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
BID	causes	gene	0.60
GENES	activates	gene	0.60
PSEN2	activates	gene	0.60
DEPRESSION	activates	gene	0.60
MAPT	activates	gene	0.60
AKT1	activates	gene	0.60
CAPN1	activates	gene	0.60
BACE1	activates	gene	0.60
NRF2	activates	gene	0.60
ERK	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
RCAN1	activates	gene	0.60
ERK1	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMPK	activates	gene	0.60
PP2A	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
KEAP1	activates	gene	0.60
CREB	activates	gene	0.60
TNF-Α	activates	gene	0.60
TAU	activates	gene	0.60
DNA	activates	gene	0.60