gene

PDGFA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

7Outgoing

8Incoming

0Experiments

0Debates

Summary

PDGFA encodes PDGF-A, a growth factor involved in glial cell development, myelination, and neuroprotection. Associated with Parkinson's disease, ALS, and white matter disorders.

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🧬 Gene Info

Gene Symbol	PDGFA
Full Name	Platelet-Derived Growth Factor Subunit A
Chromosome	7p22.3
Protein Family	Platelet-derived growth factor family
Function	is a human gene located on chromosome 7p22.
Molecular Weight	24 kDa
Amino Acids	211 aa
Exons	7
Pathways	PI3K, MAPK pathway
GeneCards	PDGFA
Human Protein Atlas	PDGFA
Associated Diseases	Parkinson's disease, ALS
Interactions	ACE2, AKT, CLU, EPHA2, GBM, HMGB2
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDGFA — Platelet-Derived Growth Factor Subunit A

gene · 766 words

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Pathway Diagram

graph TD
    PDGFA["PDGFA"]
    Ms{"Ms"}
    PDGFA -->|"interacts with"| Ms
    Glioblastoma{"Glioblastoma"}
    PDGFA -->|"therapeutic target"| Glioblastoma
    Akt(["Akt"])
    PDGFA -->|"activates"| Akt
    neurodegeneration["neurodegeneration"]
    PDGFA -->|"implicated in"| neurodegeneration
    PDGFRA["PDGFRA"]
    PDGFRA -->|"inhibits"| PDGFA
    AKT["AKT"]
    AKT -->|"activates"| PDGFA
    EPHA2["EPHA2"]
    EPHA2 -->|"inhibits"| PDGFA
    GBM["GBM"]
    GBM -->|"inhibits"| PDGFA
    style PDGFA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Glioblastoma	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
S100A9	activates	gene	0.60
PLAU	activates	gene	0.60
Akt	activates	pathway	0.60
TGM2	activates	gene	0.60
S100A8	activates	gene	0.60

Incoming (8)

Source	Relation	Type	Str
ACE2	activates	gene	0.60
HMGB2	activates	gene	0.60
PDGFRA	inhibits	gene	0.60
AKT	activates	gene	0.60
EPHA2	inhibits	gene	0.60
GBM	inhibits	gene	0.60
CLU	activates	gene	0.60
MMP12	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDGFA in their description or question text

No additional research found