concept

ACE2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ACE2
Key Genes/Proteins	ALDH1A1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOE, APOE4
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid, Apoptosis

Wiki Pages (2)

Knowledge base pages for this entity

BACE2 Gene

gene · 635 words

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BACE2 Protein

protein · 594 words

→

Pathway Diagram

graph TD
    ACE2["ACE2"]
    ACE2 -->|"targets"| SARS_CoV_2["SARS-CoV-2"]
    ACE2 -->|"binds_to"| SARS_COV_2["SARS-COV-2"]
    ACE2 -->|"targets"| Sars_Cov_2["Sars-Cov-2"]
    ACE2 -->|"binds"| Sars_Cov_2_Receptor_Binding_Do["Sars-Cov-2 Receptor Binding Domain"]
    ACE2 -->|"participates in"| Counter_regulatory_Renin_Angio["Counter-regulatory Renin-Angiotensin System"]
    ACE2 -.protects against.-> Ms["Ms"]
    SARS_CoV_2 -->|"binds"| ACE2
    FCGRT["FCGRT"] -.protects against.-> ACE2
    NEP["NEP"] -->|"activates"| ACE2
    APOPTOSIS["APOPTOSIS"] -->|"activates"| ACE2
    ALZHEIMER["ALZHEIMER"] -->|"activates"| ACE2
    NEPRILYSIN["NEPRILYSIN"] -->|"activates"| ACE2
    TAU["TAU"] -->|"activates"| ACE2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| ACE2

Outgoing (68)

Target	Relation	Type	Str
Sars-Cov-2	targets	disease	0.90
SARS-CoV-2	binds	entity	0.90
SARS-COV-2	binds_to	entity	0.90
Sars-Cov-2 Receptor Binding Domain	binds	compound	0.85
Counter-regulatory Renin-Angiotensin System	participates_in	pathway	0.80
Ang-(1-7)	produces	compound	0.80
Ang II	converts_to	compound	0.80
Als	associated_with	disease	0.65
Diabetes	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	causes	disease	0.65
Aging	causes	disease	0.65
Diabetes	causes	disease	0.65
Alzheimer	activates	disease	0.65
Ms	protects_against	disease	0.65
Als	protects_against	disease	0.65
ALS	protects_against	disease	0.65
PDGFA	activates	gene	0.60
PLAU	activates	gene	0.60
S100A8	activates	gene	0.60
S100A9	activates	gene	0.60
TGM2	activates	gene	0.60
TMPRSS2	protects_against	gene	0.60
FCGRT	protects_against	gene	0.60
neuroinflammation	associated_with	disease	0.60
CRISPR-Cas	participates_in	pathway	0.60
CLU	activates	gene	0.60
HMGB2	activates	gene	0.60
MMP12	activates	gene	0.60
TMPRSS2	interacts_with	gene	0.60
FCGRT	activates	gene	0.60
SARS	activates	gene	0.60
TMPRSS2	activates	gene	0.60
FGF21	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
FGF21	activates	gene	0.60
neurodegeneration	regulates	disease	0.60
SARS	interacts_with	gene	0.60
FCGRT	interacts_with	gene	0.60
NEP	associated_with	gene	0.60
IDE	expressed_in	gene	0.60
NEP	expressed_in	gene	0.60
IDE	activates	gene	0.60
hippocampus	expressed_in	brain_region	0.60
Apoptosis	activates	pathway	0.60
CTSD	associated_with	gene	0.60
SARS	regulates	gene	0.60
IDE	associated_with	gene	0.60

Incoming (18)

Source	Relation	Type	Str
FGF21	interacts_with	gene	0.80
HMOX1	associated_with	gene	0.60
FGF21	associated_with	gene	0.60
LPL	associated_with	gene	0.60
ALDH1A1	associated_with	gene	0.60
GUSB	associated_with	gene	0.60
SARS	inhibits	gene	0.60
NEP	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
TAU	activates	gene	0.60
FCGRT	protects_against	gene	0.60
NEURODEGENERATION	activates	gene	0.60
APOE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
SARS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACE2 in their description or question text

No additional research found