gene

MARCKS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MARCKS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

22Outgoing

14Incoming

0Experiments

0Debates

Summary

Page for MARCKS — Myristoylated Alanine-Rich Protein Kinase C Substrate

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🧬 Gene Info

Gene Symbol	MARCKS
Full Name	Myristoylated Alanine-Rich Protein Kinase C Substrate
Chromosome	6q21
Protein Type	Kinase
Function	is a key substrate of Protein Kinase C (PKC) with critical roles in synaptic plasticity, cytoskeletal dynamics, and cell signaling[@hartwig1992][@sheetz2006].
Primary Expression	Brain (neurons, glia), lung, spleen, immune cells
Pathways	PI3K/AKT/mTOR pathway
UniProt ID	P29566
NCBI Gene ID	4082
Ensembl ID	ENSG00000198237
OMIM	177620
GeneCards	MARCKS
Human Protein Atlas	MARCKS
Associated Diseases	Als, Ms
Interactions	PRKCH, TRIM1-269aa
KG Connections	36 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MARCKS — AlphaFold P29566 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MARCKS — Myristoylated Alanine-Rich Protein Kinase C Substrate

gene · 509 words

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Pathway Diagram

graph TD
    MARCKS["MARCKS"]
    PI3K_AKT_mTOR_pathway(["PI3K/AKT/mTOR pathway"])
    MARCKS -->|"activates"| PI3K_AKT_mTOR_pathway
    Cancer{"Cancer"}
    MARCKS -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    MARCKS -->|"expressed in"| Tumor
    Als{"Als"}
    MARCKS -->|"associated with"| Als
    Ms{"Ms"}
    MARCKS -->|"associated with"| Ms
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    MARCKS -->|"expressed in"| IMMUNE_INFILTRATION
    CANCER["CANCER"]
    MARCKS -->|"expressed in"| CANCER
    APP["APP"]
    MARCKS -->|"associated with"| APP
    LAMP1["LAMP1"]
    MARCKS -->|"associated with"| LAMP1
    MBP["MBP"]
    MARCKS -->|"associated with"| MBP
    LAMP2["LAMP2"]
    MARCKS -->|"associated with"| LAMP2
    MARCKS -->|"associated with"| IMMUNE_INFILTRATION
    TRIM1_269aa["TRIM1-269aa"]
    TRIM1_269aa -->|"interacts with"| MARCKS
    PRKCH["PRKCH"]
    PRKCH -->|"phosphorylates"| MARCKS
    CD4["CD4"]
    CD4 -->|"expressed in"| MARCKS
    THBS2["THBS2"]
    THBS2 -->|"expressed in"| MARCKS
    CTSK["CTSK"]
    CTSK -->|"expressed in"| MARCKS
    IL1B["IL1B"]
    IL1B -->|"associated with"| MARCKS
    SOD2["SOD2"]
    SOD2 -->|"associated with"| MARCKS
    style MARCKS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
PI3K/AKT/mTOR pathway	activates	pathway	0.90
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Epilepsy	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
LAMP2	associated_with	gene	0.60
S100A9	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
IRF1	associated_with	gene	0.60
MBP	associated_with	gene	0.60
SQSTM1	regulates	gene	0.60
Fibroblast	expressed_in	cell_type	0.60
FUS	associated_with	gene	0.60
PGRN	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
APP	associated_with	gene	0.60

Incoming (14)

Source	Relation	Type	Str
TRIM1-269aa	interacts_with	protein	0.90
PRKCH	phosphorylates	gene	0.70
CD4	expressed_in	gene	0.60
CTSK	expressed_in	gene	0.60
IL1B	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
ABCA1	regulates	gene	0.60
APOE	regulates	gene	0.60
CTSB	regulates	gene	0.60
CTSH	regulates	gene	0.60
HLA	regulates	gene	0.60
FCER1G	regulates	gene	0.60
THBS2	expressed_in	gene	0.60
EPILEPSY	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MARCKS in their description or question text

No additional research found