| Gene Symbol | RBM45 |
| Aliases | RBM45PROTEIN |
| Chromosome | 2q32.1 |
| Function | is a neuronally-expressed RNA-binding protein that has emerged as a significant player in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). |
| Primary Expression | the central nervous system, with particularly high expression in motor neurons, cortical neurons, and hippocampal pyramidal cells |
| Subcellular Localization | and stress granule dynamics |
| Molecular Weight | 46 kDa |
| Amino Acids | 405 aa |
| GeneCards | RBM45 |
| Human Protein Atlas | RBM45 |
| RNA Recognition Motifs (RRMs) | Three RRMs (RRM1, RRM2, RRM3) located in the central region of the protein: |
| RRM1 | Primary RNA-binding domain with highest affinity for target RNAs |
| RRM2 | Assists in RNA binding and contributes to specificity |
| RRM3 | Involved in protein-protein interactions and complex formation |
| C-terminal Region | Contains additional interaction motifs and nuclear localization signals |
| Associated Diseases | neurodegeneration |
| Interactions | ASCT2 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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