gene

FOXO4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

48Outgoing

26Incoming

0Experiments

0Debates

Summary

FOXO4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Als, Cancer, Carcinoma. Connected to 44 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXO4
Full Name	Forkhead Box O4
Chromosome	Xq13.1
Protein Family	Forkhead box O family
Protein Type	Transcription Factor
Function	is a transcription factor belonging to the FOX O subfamily of Forkhead box proteins.
Primary Expression	various tissues with particularly high levels in:
Molecular Weight	59.6 kDa
Amino Acids	556 aa
Exons	4
Pathways	PI3K
UniProt ID	P98177
NCBI Gene ID	8941
Ensembl ID	ENSG00000124780
OMIM	300434
GeneCards	FOXO4
Human Protein Atlas	FOXO4
Associated Diseases	Als
Interactions	Actin, AKT, AMPK, AUTOPHAGY, CAMKII, CBL
KG Connections	74 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FOXO4 — AlphaFold P98177 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FOXO4 — Forkhead Box O4

gene · 3329 words

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Pathway Diagram

graph TD
    FOXO4["FOXO4"]
    Ms{"Ms"}
    FOXO4 -->|"activates"| Ms
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    FOXO4 -->|"therapeutic target"| Traumatic_Brain_Injury
    Als{"Als"}
    FOXO4 -->|"therapeutic target"| Als
    Diabetes{"Diabetes"}
    FOXO4 -->|"expressed in"| Diabetes
    Cancer{"Cancer"}
    FOXO4 -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    FOXO4 -->|"expressed in"| Carcinoma
    Longevity{"Longevity"}
    FOXO4 -->|"therapeutic target"| Longevity
    FOXO4 -->|"associated with"| Als
    Tumor{"Tumor"}
    FOXO4 -->|"therapeutic target"| Tumor
    Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
    FOXO4 -->|"activates"| Ubiquitin_Proteasome
    Akt(["Akt"])
    FOXO4 -->|"activates"| Akt
    Autophagy(["Autophagy"])
    FOXO4 -->|"activates"| Autophagy
    FOXO1["FOXO1"]
    FOXO1 -->|"contributes to"| FOXO4
    AKT["AKT"]
    AKT -->|"activates"| FOXO4
    AMPK["AMPK"]
    AMPK -->|"activates"| FOXO4
    CBL["CBL"]
    CBL -->|"activates"| FOXO4
    FOXA2["FOXA2"]
    FOXA2 -->|"associated with"| FOXO4
    FOXO6["FOXO6"]
    FOXO6 -->|"associated with"| FOXO4
    FOXK2["FOXK2"]
    FOXK2 -->|"associated with"| FOXO4
    FOXO3["FOXO3"]
    FOXO3 -->|"associated with"| FOXO4
    FOXP3["FOXP3"]
    FOXP3 -->|"associated with"| FOXO4
    FOXG1["FOXG1"]
    FOXG1 -->|"associated with"| FOXO4
    FOXD3["FOXD3"]
    FOXD3 -->|"associated with"| FOXO4
    SHH["SHH"]
    SHH -->|"expressed in"| FOXO4
    style FOXO4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (48)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Longevity	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Traumatic Brain Injury	therapeutic_target	disease	0.65
Ms	contributes_to	disease	0.65
Longevity	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65
Aging	contributes_to	disease	0.65
Cardiovascular	contributes_to	disease	0.65
APOPTOSIS	contributes_to	gene	0.60
Apoptosis	contributes_to	pathway	0.60
AKT	activates	gene	0.60
LYSOSOME	activates	gene	0.60
AMPK	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Actin	activates	protein	0.60
CANCER	contributes_to	gene	0.60
FOXM1	associated_with	gene	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Akt	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Proteasome	activates	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
Hedgehog	expressed_in	pathway	0.60
CAMKII	activates	gene	0.60
FOXP1	associated_with	gene	0.60
Stem Cell	activates	cell_type	0.60
SHH	expressed_in	gene	0.60
FOXO3	associated_with	gene	0.60
FOXA2	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
GENES	associated_with	gene	0.60
FOXK2	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
FOXO1	associated_with	gene	0.60
Rb	activates	protein	0.60
Stem Cell	expressed_in	cell_type	0.55

Incoming (26)

Source	Relation	Type	Str
FOXK2	associated_with	gene	0.60
FOXD3	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
AUTOPHAGY	activates	gene	0.60
LYSOSOME	activates	gene	0.60
CAMKII	activates	gene	0.60
FOXO	contributes_to	gene	0.60
FOXO1	associated_with	gene	0.60
AKT	activates	gene	0.60
CBL	activates	gene	0.60
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXP1	associated_with	gene	0.60
FOXM1	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
AGING	contributes_to	gene	0.60
AMPK	activates	gene	0.60
FOXO	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FOXO4 in their description or question text

No additional research found