| Gene Symbol | RBPJL |
| Full Name | Recombination Binding Protein Lambda |
| Chromosome | 20q13.12 |
| Protein Type | Transcription Factor |
| Function | encodes a transcription factor that functions as a key component of the Notch signaling pathway. |
| Primary Expression | pancreatic islets |
| Pathways | Notch signaling, Notch, Notch pathway |
| UniProt ID | [Q9Y244](https://www.uniprot.org/uniprot/Q9Y244) |
| Ensembl ID | ENSG00000166323 |
| GeneCards | RBPJL |
| Human Protein Atlas | RBPJL |
| N-terminal domain | Contains the DNA-binding motif that recognizes the consensus RBPJ binding sequence (CGTGGGAA) |
| Rel-homology region (RHR) | Core transcription regulatory domain |
| C-terminal activation/repression domain | Modulates transcriptional activity based on cellular context |
| Notch interaction domain | Mediates binding to Notch receptor intracellular domains |
| Associated Diseases | Dementia |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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