concept

FUT8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FUT8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

0Hypotheses

1Analyses

50Outgoing

34Incoming

0Experiments

1Debates

Summary

FUT8 is a concept in neurodegeneration research. Key relationships include: regulates, associated with, co discussed. Associated with ALS, Als, Arthritis. Connected to 57 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	FUT8
Key Genes/Proteins	AKT, AND, APOE, APOE4, APP, B3GAT1
Related Diseases	als, Als, ALS, Arthritis, cancer

🔮 Predicted Structure: FUT8 — AlphaFold A0A669KAW1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    FUT8["FUT8"]
    FUT8 -->|"mediates"| IgG_Core_Fucosylation["IgG Core Fucosylation"]
    FUT8 -->|"regulates"| Als["Als"]
    FUT8 -->|"regulates"| Cancer["Cancer"]
    FUT8 -->|"regulates"| Ms["Ms"]
    FUT8 -->|"activates"| Arthritis["Arthritis"]
    FUT8 -->|"transports"| ALS["ALS"]
    FUT8 -->|"expressed in"| ST6GAL1["ST6GAL1"]
    FUT8 -->|"regulates"| Tgf__["Tgf-Beta"]
    FUT8 -->|"regulates"| ERBB3["ERBB3"]
    h_9a108e26["h-9a108e26"] -->|"targets"| FUT8
    JUN["JUN"] -->|"regulates"| FUT8
    APP["APP"] -->|"regulates"| FUT8
    ST6GAL1 -->|"regulates"| FUT8
    MAX["MAX"] -->|"regulates"| FUT8
    EGFR["EGFR"] -->|"regulates"| FUT8
    BACE1["BACE1"] -->|"regulates"| FUT8
    ERBB3 -->|"regulates"| FUT8
    TCR["TCR"] -->|"regulates"| FUT8
    AND["AND"] -->|"regulates"| FUT8

Outgoing (78)

Target	Relation	Type	Str
N-glycosylation pathway	involved_in	pathway	0.95
α2,6-sialylation	suppresses	process	0.90
Igg Glycosylation	regulates	process	0.90
Transferrin Glycosylation	regulates	process	0.90
EGFR	associated_with	protein	0.85
Glycoprotein Sialylation	regulates	process	0.85
Tgfbr1	modulates	protein	0.80
Various Human Diseases	associated_with	disease	0.70
ST6GAL1	associated_with	gene	0.70
Arthritis	activates	disease	0.65
Als	transports	disease	0.65
ALS	activates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	transports	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
GENES	associated_with	gene	0.60
CANCER	regulates	gene	0.60
JUN	regulates	gene	0.60
AND	expressed_in	gene	0.60
ST6GAL1	regulates	gene	0.60
MAX	associated_with	gene	0.60
AND	activates	gene	0.60
TCR	regulates	gene	0.60
B Cell	activates	cell_type	0.60
Egfr	regulates	protein	0.60
Transferrin	associated_with	protein	0.60
EGFR	regulates	gene	0.60
BACE1	regulates	gene	0.60
APP	regulates	gene	0.60
MAX	regulates	gene	0.60
PI3K	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
AKT	regulates	gene	0.60
ST6GAL1	upregulates	entity	0.60
Rb	regulates	protein	0.60
Tgf-Β	regulates	pathway	0.60
ST6GAL1	expressed_in	gene	0.60
ST6GAL1	activates	gene	0.60
JUN	transports	gene	0.60
Epithelial	regulates	cell_type	0.60
ERBB3	regulates	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
Neurogenesis	regulates	pathway	0.60
Differentiation	inhibits	pathway	0.60
Immune Response	regulates	pathway	0.60
B Cell	transports	cell_type	0.60
TRIM21	activates	gene	0.60
Ras	associated_with	protein	0.60

Incoming (34)

Source	Relation	Type	Str
h-9a108e26	targets	hypothesis	0.90
ERBB3	associated_with	gene	0.60
ST6GAL1	associated_with	gene	0.60
AND	regulates	gene	0.60
JUN	transports	gene	0.60
GENES	associated_with	gene	0.60
ST6GAL1	expressed_in	gene	0.60
ST6GAL1	activates	gene	0.60
FUT6	interacts_with	gene	0.60
MAX	regulates	gene	0.60
EGFR	regulates	gene	0.60
BACE1	regulates	gene	0.60
APP	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
JUN	regulates	gene	0.60
APP	regulates	gene	0.60
ST6GAL1	regulates	gene	0.60
ERBB3	regulates	gene	0.60
TCR	regulates	gene	0.60
APOE4	activates	gene	0.55
APOE4	regulates	gene	0.55
APOE4	interacts_with	gene	0.55
APOE4	expressed_in	gene	0.55
B Cell	associated_with	cell_type	0.50
B Cell	activates	cell_type	0.50
TRANSFERRIN	interacts_with	protein	0.50
ST6GAL1	interacts_with	gene	0.43
DNAJB1	co_discussed	gene	0.40
ST6GAL1	co_discussed	gene	0.40
HSPA1A	co_discussed	gene	0.40
HSP90AA1	co_discussed	gene	0.40
FKBP5	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning FUT8 in their description or question text

No additional research found