| Gene Symbol | RBPJ |
| Full Name | Recombination Signal Binding Protein for Immunoglobulin Kappa J Region |
| Chromosome | 4q25 |
| Protein Type | Transcription Factor |
| Function | is a critical transcription factor that serves as the primary mediator of Notch signaling. |
| Primary Expression | cortical layers II-VI, particularly in layer 2/3 pyramidal neurons |
| Amino Acids | 434 aa |
| Pathways | Notch signaling, Notch, Notch Signaling, NOTCH |
| UniProt ID | [Q06323](https://www.uniprot.org/uniprot/Q06323) |
| Ensembl ID | ENSG00000168214 |
| GeneCards | RBPJ |
| Human Protein Atlas | RBPJ |
| p53-mediated apoptosis | RBPJ can interact with p53 to modulate apoptotic responses |
| TFII-I interactions | RBPJ interacts with general transcription factors to regulate housekeeping genes |
| Chromatin remodeling | RBPJ recruits chromatin modifiers independent of Notch signaling |
| Associated Diseases | neurodegeneration |
| Interactions | AKT1, CANCER, CXCL1, NOTCH1, RNA, STAT3 |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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