gene

NDUFA9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFA9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

Gene encoding a core subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase), essential for oxidative phosphorylation and implicated in Leigh syndrome and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	NDUFA9
Full Name	NADH:Ubiquinone Oxidoreductase Subunit A9
Aliases	NADH:ubiquinone oxidoreductase
Chromosome	12p12.3
Protein Type	Oxidoreductase
Function	Catalyzes electron transfer from NADH to ubiquinone
Primary Expression	all tissues with high energy requirements: - Heart: Highest expression (cardiac muscle) - Skeletal Muscle: High oxidative fiber expression -
Molecular Weight	39kDa
Amino Acids	377 aa
Pathways	Akt, Cell Cycle, Pi3K
UniProt ID	O96070
NCBI Gene ID	4704
GeneCards	NDUFA9
Human Protein Atlas	NDUFA9
Associated Diseases	Alzheimer, Alzheimer's Disease, Huntington, Neurodegenerative Disorders, Parkinson
Interactions	ALZHEIMER, AND, GENES, HIP1, HUNTINGTON, HUNTINGTON'S DISEASE
KG Connections	118 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDUFA9 — AlphaFold O96070 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NDUFA9 Gene

gene · 1453 words

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NDUFA9 Protein

protein · 657 words

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Pathway Diagram

graph TD
    NDUFA9["NDUFA9"]
    Parkinson_s_Disease{"Parkinson's Disease"}
    NDUFA9 -->|"associated with"| Parkinson_s_Disease
    Alzheimer{"Alzheimer"}
    NDUFA9 -->|"associated with"| Alzheimer
    Ms{"Ms"}
    NDUFA9 -->|"regulates"| Ms
    Parkinson{"Parkinson"}
    NDUFA9 -->|"regulates"| Parkinson
    Huntington{"Huntington"}
    NDUFA9 -->|"associated with"| Huntington
    NDUFA9 -->|"associated with"| Parkinson
    Prion_Disease{"Prion Disease"}
    NDUFA9 -->|"associated with"| Prion_Disease
    Pi3K(["Pi3K"])
    NDUFA9 -->|"regulates"| Pi3K
    Akt(["Akt"])
    NDUFA9 -->|"regulates"| Akt
    TUBB["TUBB"]
    NDUFA9 -->|"associated with"| TUBB
    PI3K["PI3K"]
    NDUFA9 -->|"regulates"| PI3K
    GENES["GENES"]
    NDUFA9 -->|"associated with"| GENES
    TUBB -->|"associated with"| NDUFA9
    SNCA["SNCA"]
    SNCA -->|"associated with"| NDUFA9
    TUBB3["TUBB3"]
    TUBB3 -->|"associated with"| NDUFA9
    SLC6A3["SLC6A3"]
    SLC6A3 -->|"associated with"| NDUFA9
    TUBB4B["TUBB4B"]
    TUBB4B -->|"associated with"| NDUFA9
    AKT["AKT"]
    AKT -->|"associated with"| NDUFA9
    PI3K -->|"regulates"| NDUFA9
    AKT -->|"regulates"| NDUFA9
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| NDUFA9
    AND["AND"]
    AND -->|"associated with"| NDUFA9
    GENES -->|"associated with"| NDUFA9
    style NDUFA9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFA9	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Parkinson'S Disease	associated_with	disease	0.95
Neurodegenerative Disorders	associated_with	disease	0.88
Alzheimer'S Disease	associated_with	disease	0.85
Parkinson's Disease	biomarker_for	disease	0.85
Parkinson's Disease	associated_with	disease	0.85
Alzheimer's Disease	associated_with	disease	0.80
Alzheimer	associated_with	disease	0.65
Ms	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Huntington	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Prion Disease	associated_with	disease	0.65
Huntington	therapeutic_target	disease	0.65
Huntington	interacts_with	disease	0.65
Prion	associated_with	disease	0.65
AKT	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
TUBB4B	associated_with	gene	0.60
AND	associated_with	gene	0.60
Dopaminergic	regulates	cell_type	0.60
HUNTINGTON'S DISEASE	interacts_with	gene	0.60
HUNTINGTON	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MIRNAS	interacts_with	gene	0.60
MIR-34A	interacts_with	gene	0.60
SNCA	associated_with	gene	0.60
Rb	regulates	protein	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
Cell Cycle	regulates	pathway	0.60
SLC6A3	associated_with	gene	0.60
TUBB	associated_with	gene	0.60
PI3K	regulates	gene	0.60
NRF1	interacts_with	gene	0.60
PI3K	associated_with	gene	0.60
Akt	associated_with	pathway	0.60
Cell Cycle	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
Actin	therapeutic_target	protein	0.60
HUNTINGTON	therapeutic_target	gene	0.60
Akt	regulates	pathway	0.60
SLC6A3	regulates	entity	0.60
SNCA	regulates	entity	0.60

Incoming (32)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFA9	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
NRF1	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AKT	associated_with	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
TUBB4B	associated_with	gene	0.60
HIP1	interacts_with	gene	0.60
SYNAPSE	regulates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
GENES	interacts_with	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
TUBB	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
IDH2	interacts_with	gene	0.55
NADPH	interacts_with	gene	0.55
TUBB4B	interacts_with	gene	0.50
SNCA	interacts_with	gene	0.50
AKT	co_discussed	protein	0.50
ALZHEIMER	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
HUNTINGTON	co_discussed	gene	0.50
TGM2	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFA9 in their description or question text

No additional research found