concept

VESICLE TRAFFICKING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VESICLE TRAFFICKING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

271Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

VESICLE TRAFFICKING is a concept in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with ALS, Aging, Als. Connected to 161 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	VESICLE TRAFFICKING
Key Genes/Proteins	ACACA, ACTB, ACTG1, AKT, ALS2, ALZHEIMER
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"]
    VESICLE_TRAFFICKING -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    VESICLE_TRAFFICKING -->|"expressed in"| Ms["Ms"]
    VESICLE_TRAFFICKING -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    VESICLE_TRAFFICKING -->|"expressed in"| Dementia["Dementia"]
    VESICLE_TRAFFICKING -->|"activates"| Cancer["Cancer"]
    VESICLE_TRAFFICKING -->|"activates"| Tumor["Tumor"]
    C9ORF72["C9ORF72"] -->|"regulates"| VESICLE_TRAFFICKING
    RAB5["RAB5"] -->|"activates"| VESICLE_TRAFFICKING
    OPTN["OPTN"] -->|"participates in"| VESICLE_TRAFFICKING
    SQSTM1["SQSTM1"] -->|"participates in"| VESICLE_TRAFFICKING
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| VESICLE_TRAFFICKING
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"interacts"| VESICLE_TRAFFICKING
    ATG14["ATG14"] -->|"interacts"| VESICLE_TRAFFICKING
    UVRAG["UVRAG"] -->|"interacts"| VESICLE_TRAFFICKING
    MAP1LC3["MAP1LC3"] -->|"interacts"| VESICLE_TRAFFICKING

Outgoing (166)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	involved_in	disease	0.90
C9Orf72-Associated Neurodegeneration	modulates	mechanism	0.90
Neurodegeneration	modulates	process	0.90
Frontotemporal Dementia	involved_in	disease	0.85
Ferroptosis	involved_in	process	0.80
ALS	associated_with	disease	0.80
FTD	associated_with	disease	0.80
Neurodegeneration	regulates	disease	0.75
Als	associated_with	disease	0.75
Als	regulates	disease	0.75
Inflammation	associated_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Parkinson	regulates	disease	0.65
Als	causes	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
Ms	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Dementia	causes	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Dementia	regulates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	contributes_to	disease	0.65
Als	interacts_with	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
ALS	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Ms	activates	disease	0.65

Incoming (105)

Source	Relation	Type	Str
C9ORF72	regulates	gene	0.95
C9ORF72	regulates	protein	0.95
OPTN	modulates	protein	0.95
RAB7L1	regulates	protein	0.95
C9ORF72	regulates	gene	0.90
SEC24B	involved_in	gene	0.90
C9ORF72	involved_in	protein	0.90
LRRK2	regulates	gene	0.80
RAB5	activates	protein	0.80
CHMP2B	involved_in	gene	0.80
FIG4	involved_in	gene	0.75
SQSTM1	involved_in	gene	0.75
ALS2	involved_in	gene	0.75
OPTN	participates_in	gene	0.70
SQSTM1	participates_in	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
MOTOR NEURONS	interacts_with	gene	0.60
RAB7A	interacts_with	gene	0.60
C9ORF72	transports	gene	0.60
MOTOR NEURONS	activates	gene	0.60
GAIN	activates	gene	0.60
CBL	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
PI3K	activates	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
PARKINSON	regulates	gene	0.60
ALS2	causes	gene	0.60
NEURON	interacts_with	gene	0.60
GAIN	causes	gene	0.60
RAB5	causes	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
SEC24B	regulates	gene	0.60
FASN	associated_with	gene	0.60
ATG14	interacts_with	gene	0.60
UVRAG	interacts_with	gene	0.60
CHMP2B	causes	gene	0.60
FIG4	causes	gene	0.60
C9ORF72 REPEAT EXPANSION	regulates	gene	0.60
CHMP2A	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
SYN1	activates	gene	0.60
MBP	activates	gene	0.60
GFAP	activates	gene	0.60
AXON	activates	gene	0.60
GENES	contributes_to	gene	0.60
LDL	contributes_to	gene	0.60
SREBF1	regulates	gene	0.60
SREBF2	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte CD38-erk Mapk signaling controls mitochondrial tra	0.380	ALS and Alzheimer's disease	Mitochondrial transfer between neurons a

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VESICLE TRAFFICKING in their description or question text

No additional research found