protein

NUCLEOLIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUCLEOLIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

46Outgoing

14Incoming

0Experiments

0Debates

Summary

NUCLEOLIN is a protein involved in neurodegeneration research. Key relationships include: biomarker for, expressed in, implicated in. Associated with ALS, Alzheimer, Autoimmune. Connected to 13 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NCL
Aliases	NUCLEOLIN
Protein Family	Nucleolin Family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	proliferating cancer cells - Promotes angiogenesis via VEGF - Cell surface nucleolin targeted by anticancer drugs (e
Subcellular Localization	Nucleolus, Nucleus, Cytoplasm, Cell Surface
Molecular Weight	76 kDa
Pathways	Apoptosis, Chromatin Remodeling, DNA Replication
UniProt ID	P19367
GeneCards	NCL
Human Protein Atlas	NCL
N-terminal Domain	Acidic stretches (aspartate/glutamate-rich) for protein-protein interactions
Central Region	Contains four RNA recognition motifs (RRMs)
C-terminal Domain	Arginine-glycine-glycine (RGG) repeats for RNA binding
Nuclear Localization Signals (NLS)	Multiple NLS sequences
Associated Diseases	Alzheimer'S Disease, Autoimmune, cancer, disease, DISEASES
Interactions	Actin, AND, DNA, HNRNPA2B1, HNRPU, Proteins
KG Connections	60 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NUCLEOLIN — AlphaFold P19367 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Nucleolin Protein

protein · 576 words

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Pathway Diagram

graph TD
    NUCLEOLIN["NUCLEOLIN"]
    Autoimmune{"Autoimmune"}
    NUCLEOLIN -->|"biomarker for"| Autoimmune
    ALS{"ALS"}
    NUCLEOLIN -->|"biomarker for"| ALS
    Alzheimer{"Alzheimer"}
    NUCLEOLIN -->|"biomarker for"| Alzheimer
    Cancer{"Cancer"}
    NUCLEOLIN -->|"biomarker for"| Cancer
    Apoptosis(["Apoptosis"])
    NUCLEOLIN -->|"expressed in"| Apoptosis
    CANCER["CANCER"]
    NUCLEOLIN -->|"biomarker for"| CANCER
    neurodegeneration["neurodegeneration"]
    NUCLEOLIN -->|"implicated in"| neurodegeneration
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| NUCLEOLIN
    DNA["DNA"]
    DNA -->|"expressed in"| NUCLEOLIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"biomarker for"| NUCLEOLIN
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"biomarker for"| NUCLEOLIN
    VIRAL_INFECTIONS["VIRAL INFECTIONS"]
    VIRAL_INFECTIONS -->|"biomarker for"| NUCLEOLIN
    CANCER -->|"biomarker for"| NUCLEOLIN
    AND["AND"]
    AND -->|"expressed in"| NUCLEOLIN
    style NUCLEOLIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Chromatin Remodeling	involved_in	process	0.90
Gene Expression	regulates	process	0.88
Cell Proliferation	modulates	process	0.87
DNA Replication	involved_in	process	0.85
Apoptosis	involved_in	process	0.80
DISEASES	implicated_in	disease	0.70
Cancer	biomarker_for	disease	0.65
Autoimmune	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
ALS	inhibits	disease	0.65
DNA	inhibits	gene	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
Dna Repair	inhibits	pathway	0.60
RNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
VIRAL INFECTIONS	biomarker_for	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
Cytokine	expressed_in	protein	0.60
Actin	inhibits	protein	0.60
SRPK1	inhibits	gene	0.60
Ras	expressed_in	protein	0.60
TAF15	inhibits	gene	0.60
HNRPU	inhibits	gene	0.60
HNRNPA2B1	inhibits	gene	0.60
Apoptosis	expressed_in	pathway	0.60
CANCER	biomarker_for	gene	0.60
DNA	expressed_in	gene	0.60
cancer	associated_with	disease	0.50
cancer	inhibits	disease	0.50
Proteins	inhibits	protein	0.50
Alzheimer'S Disease	associated_with	disease	0.50
Autoimmune	associated_with	disease	0.50
VIRAL INFECTIONS	associated_with	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
Drug Resistance	associated_with	pathway	0.50
Chaperone	associated_with	pathway	0.50
disease	associated_with	disease	0.50
Proteins	associated_with	protein	0.50
apoptosis	expressed_in	process	0.50
GENE EXPRESSION	expressed_in	concept	0.50
ALZHEIMER	associated_with	gene	0.50

Incoming (14)

Source	Relation	Type	Str
TAF15	inhibits	gene	0.60
HNRNPA2B1	inhibits	gene	0.60
HNRPU	inhibits	gene	0.60
SRPK1	inhibits	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
VIRAL INFECTIONS	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60
RNA	expressed_in	gene	0.60
DNA	inhibits	gene	0.60
RNA	inhibits	gene	0.60
CANCER	inhibits	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NUCLEOLIN in their description or question text

No additional research found