concept

PD-L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PD-L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

382Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PD-L1
Key Genes/Proteins	Akt, AND, APOB, APOPTOSIS, App, ARG1
Related Diseases	Aging, Als, ALS
Related Pathways	Apoptosis, Autophagy

Wiki Pages (1)

Knowledge base pages for this entity

PD-1/PD-L1 Immune Checkpoint Signaling in Neurodegeneration

mechanism · 3120 words

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Pathway Diagram

graph TD
    PD_L1["PD-L1"]
    PD_L1 -->|"promotes"| IL_6["IL-6"]
    PD_L1 -->|"inhibits"| T_Cell_Activity["T Cell Activity"]
    PD_L1 -->|"activates"| Jak2_Stat3_signaling["Jak2/Stat3 signaling"]
    PD_L1 -->|"binds"| PD_1["PD-1"]
    PD_L1 -->|"inhibits"| T_cells["T cells"]
    PD_L1 -->|"promotes"| oral_squamous_cell_carcinoma["oral squamous cell carcinoma"]
    PD_L1 -->|"inhibits"| PTPN1["PTPN1"]
    PD_L1 -->|"inhibits"| T_cell_function["T-cell function"]
    PER2["PER2"] -->|"inhibits"| PD_L1
    PINK1["PINK1"] -->|"recruits_to_mitochondria"| PD_L1
    OMA1["OMA1"] -->|"upregulates"| PD_L1
    PD_1 -->|"inhibits"| PD_L1
    TCe6_Cu_TP5_NPs["TCe6@Cu/TP5 NPs"] -->|"downregulates"| PD_L1
    NF__B["NF-kappaB"] -->|"activates"| PD_L1
    SMARCAL1["SMARCAL1"] -->|"promotes"| PD_L1
    Atezolizumab["Atezolizumab"] -->|"targets"| PD_L1

Outgoing (226)

Target	Relation	Type	Str
IL-6	promotes	protein	0.95
T Cell Activity	inhibits	process	0.95
Jak2/Stat3 signaling	activates	pathway	0.93
Immunotherapy	regulates	process	0.90
PTPN1	inhibits	protein	0.90
T-cell function	inhibits	process	0.90
T cells	inhibits	cell_type	0.90
oral squamous cell carcinoma	promotes	disease	0.90
STAT3	binds_to	protein	0.89
Cancer Cell Proliferation	involved_in	process	0.85
T Cell Cytotoxicity	inhibits	process	0.85
Systemic Immune Suppression	mediates	process	0.80
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Tumor	degrades	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	degrades	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	biomarker_for	disease	0.65
Als	activates	disease	0.65
Glioblastoma	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
AND	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TERT	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
Wnt	inhibits	pathway	0.60
MDM4	inhibits	gene	0.60
RNA	inhibits	gene	0.60
P53	inhibits	gene	0.60
Immune Response	inhibits	pathway	0.60
EEF1A1	inhibits	gene	0.60
Dna Methylation	inhibits	pathway	0.60
Endocytosis	activates	pathway	0.60
APOB	inhibits	gene	0.60

Incoming (156)

Source	Relation	Type	Str
PER2	inhibits	gene	0.95
OMA1	upregulates	protein	0.95
PD-1	inhibits	gene	0.95
PINK1	recruits_to_mitochondria	protein	0.95
Atezolizumab	targets	drug	0.90
Durvalumab	targets	drug	0.90
SMARCAL1	promotes	gene	0.90
TCe6@Cu/TP5 NPs	downregulates	compound	0.90
NF-κB	activates	pathway	0.90
Avelumab	targets	drug	0.90
cGAS-STING Pathway	upregulates	pathway	0.90
STING1	associated_with	protein	0.90
type I interferon	associated_with	protein	0.90
JUN	interacts_with	protein	0.85
NUPR1	upregulates	gene	0.85
brain metastases	associated_with	disease	0.70
PD-1	activates	gene	0.65
GBM	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
OMA1	interacts_with	gene	0.60
MITOPHAGY	activates	gene	0.60
OMA1	activates	gene	0.60
HSPA9	therapeutic_target	gene	0.60
DNA	activates	gene	0.60
LC3	degrades	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CGAS-STING	therapeutic_target	gene	0.60
FASN	activates	gene	0.60
ARG1	activates	gene	0.60
IL-10	activates	gene	0.60
CHI3L1	activates	gene	0.60
MMP9	activates	gene	0.60
LCN2	activates	gene	0.60
HBB	activates	gene	0.60
IL-17	activates	gene	0.60
IL-18	expressed_in	gene	0.60
ERBB2	activates	gene	0.60
SF3B1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
HSPA9	associated_with	gene	0.60
CD8	inhibits	gene	0.60
HDAC	inhibits	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PD-L1 in their description or question text

No additional research found