concept

B CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

206Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	B CELLS
Key Genes/Proteins	AKT, AMPK, AQP4, BAX, BCL2, BDNF
Related Diseases	AGING, CANCER

Pathway Diagram

graph TD
    B_CELLS["B CELLS"]
    B_CELLS -->|"mediates"| Tolerance_To_AQP4["Tolerance To AQP4"]
    B_CELLS -->|"activates"| NF_KB["NF-KB"]
    B_CELLS -->|"regulates"| Immune_Tolerance["Immune Tolerance"]
    B_CELLS -->|"contributes to"| Salivary_Gland_Damage["Salivary Gland Damage"]
    B_CELLS -->|"regulates"| AQP4["AQP4"]
    B_CELLS -->|"involved_in"| Neuromyelitis_Optica["Neuromyelitis Optica"]
    DDX5["DDX5"] -->|"regulates"| B_CELLS
    APOPTOSIS["APOPTOSIS"] -->|"activates"| B_CELLS
    AQP4 -->|"activates"| B_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| B_CELLS
    AKT["AKT"] -->|"activates"| B_CELLS

Outgoing (93)

Target	Relation	Type	Str
Tolerance To AQP4	mediates	process	0.95
Tolerance	mediates	process	0.95
NF-KB	activates	gene	0.95
Immune Tolerance	regulates	process	0.90
AQP4	regulates	protein	0.90
AQP4	regulates	protein	0.90
Salivary Gland Damage	contributes_to	phenotype	0.90
Autoimmune Response	suppresses	process	0.85
AQP4	interacts_with	protein	0.85
AQP4	associated_with	protein	0.85
Neuromyelitis Optica	involved_in	disease	0.85
Immune Tolerance	mediates	process	0.85
Autoimmune Tolerance	regulates	process	0.85
Neuromyelitis Optica	protects_against	disease	0.85
LYMPHOMA	activates	disease	0.80
Immune Tolerance	mediates	process	0.80
T CELLS	interacts_with	cell_type	0.80
MS	associated_with	disease	0.80
central nervous system	involved_in	brain_region	0.80
Autoimmune Disease	participates_in	disease	0.80
neuromyelitis optica spectrum disorder	biomarker_for	disease	0.80
MACROPHAGES	treats	cell_type	0.70
Neuromyelitis optica spectrum disorder activity	related_to	disease	0.70
LYMPHOMA	interacts_with	disease	0.65
INFLAMMATION	activates	process	0.65
LYMPHOMA	regulates	disease	0.65
LYMPHOMA	inhibits	disease	0.65
T CELLS	activates	cell_type	0.65
MULTIPLE SCLEROSIS	implicated_in	disease	0.55
LYMPHOMA	associated_with	disease	0.55
CASP3	activates	gene	0.50
BCL2	interacts_with	gene	0.50
BAX	interacts_with	gene	0.50
IL-6	activates	gene	0.50
BCL2	activates	gene	0.50
ENDOTHELIAL CELLS	interacts_with	cell_type	0.50
FIBROBLASTS	interacts_with	cell_type	0.50
MACROPHAGES	activates	cell_type	0.50
DENDRITIC CELLS	associated_with	concept	0.50
IL-10	activates	gene	0.35
GLIOBLASTOMA	interacts_with	disease	0.35
CD8	interacts_with	gene	0.35
CANCER	associated_with	disease	0.35
MACROPHAGES	interacts_with	cell_type	0.35
NEUTROPHILS	interacts_with	cell_type	0.35
BCL2	inhibits	gene	0.35
P53	inhibits	gene	0.35
BCL2	regulates	gene	0.35
FERROPTOSIS	interacts_with	process	0.35
FERROPTOSIS	associated_with	process	0.35

Incoming (113)

Source	Relation	Type	Str
NF-kB signaling	active_in	pathway	0.90
spinal muscular atrophy	affects	disease	0.80
DDX5	regulates	gene	0.80
unfolded protein response	active_in	pathway	0.70
MOG	exacerbates	gene	0.70
CD8	associated_with	gene	0.70
CD4	associated_with	gene	0.70
BDNF	activates	gene	0.65
AQP4	treats	gene	0.65
AGING	activates	phenotype	0.65
CXCL10	activates	gene	0.65
ROS	activates	phenotype	0.65
AMPK signaling	active_in	pathway	0.60
BCL2	releases	gene	0.60
AQP4	activates	gene	0.60
BCL2	regulates	gene	0.60
AQP4	expressed_in	gene	0.60
AQP4	associated_with	gene	0.60
GFAP	regulates	gene	0.60
multiple sclerosis	affects	disease	0.60
TLR	activates	gene	0.60
RNA	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
Golgi apparatus	found_in	organelle	0.60
CD38	regulates	gene	0.60
MTOR	regulates	gene	0.60
ATP	activates	gene	0.60
NAMPT	activates	gene	0.60
glioblastoma	affects	disease	0.60
NAD	activates	gene	0.60
AMPK	activates	gene	0.60
DNA	regulates	gene	0.60
NMDA receptor	expressed_in	receptor	0.60
MYC	activates	gene	0.60
glutamate signaling	active_in	pathway	0.60
MYC	expressed_in	gene	0.60
IL1B	associated_with	gene	0.60
AQP4	inhibits	gene	0.60
DNA	modulates	gene	0.60
AQP4	treats	gene	0.60
GFAP	activates	gene	0.60
ATP	regulates	gene	0.60
AGING	participates_in	phenotype	0.55
AQP4	associated_with	gene	0.50
inflammation	activates	pathway	0.50
disease	expressed_in	disease	0.50
B Cell	activates	cell_type	0.50
Microrna	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
DICER1	interacts_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B CELLS in their description or question text

No additional research found