concept

LEWY BODY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LEWY BODY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

251Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LEWY BODY
Key Genes/Proteins	Alpha-Synuclein, ALPHA-SYNUCLEIN, AMYLOID, APP
Related Diseases	acetylcholine, aging, ALZHEIMER, ALZHEIMER'S, Alzheimer'S Disease
Related Pathways	Chaperone

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Lewy Body Society

institution · 1988 words

→

Pathway Diagram

graph TD
    LEWY_BODY["LEWY BODY"]
    style LEWY_BODY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    LEWY_BODY -->|"regulates"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    LEWY_BODY -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    LEWY_BODY -->|"causes"| NEURON["/NEURON/"]
    LEWY_BODY -->|"causes"| PRION_LIKE["PRION-LIKE"]
    LEWY_BODY -->|"expressed in"| NEURONS["/NEURONS/"]
    LEWY_BODY -->|"contributes to"| PARKIN([PARKIN])
    LEWY_BODY -->|"contributes to"| PARKINSON["PARKINSON"]
    LEWY_BODY -->|"contributes to"| PARKINSON_S["PARKINSON'S"]
    LEWY_BODY -->|"contributes to"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    __synuclein(["alpha-synuclein"]) -->|"activates"| LEWY_BODY
    DEMENTIA([DEMENTIA]) -->|"contributes to"| LEWY_BODY
    CD4([CD4]) -->|"regulates"| LEWY_BODY
    PARKINSON_S_DISEASE -->|"causes"| LEWY_BODY
    PARKINSON -->|"causes"| LEWY_BODY
    NEURODEGENERATIVE_DISORDERS([NEURODEGENERATIVE DISORDERS]) -->|"causes"| LEWY_BODY
    GUT_BRAIN_AXIS([GUT-BRAIN AXIS]) -->|"causes"| LEWY_BODY
    INFLAMMATION([INFLAMMATION]) -->|"causes"| LEWY_BODY
    NEURODEGENERATION -->|"causes"| LEWY_BODY
    ALPHA_SYNUCLEIN([ALPHA-SYNUCLEIN]) -->|"causes"| LEWY_BODY

Outgoing (60)

Target	Relation	Type	Str
MULTIPLE SCLEROSIS	regulates	disease	0.65
NEURONS	expressed_in	cell_type	0.60
NEURODEGENERATION	causes	disease	0.60
NEURON	causes	cell_type	0.60
NEURODEGENERATION	interacts_with	disease	0.60
NEURON	expressed_in	cell_type	0.60
TEMPORAL LOBE	regulates	brain_region	0.60
LRRK2	activates	gene	0.60
PARKIN	contributes_to	gene	0.60
PARKINSON	contributes_to	disease	0.60
PARKINSON'S	contributes_to	disease	0.60
PARKINSON'S DISEASE	contributes_to	disease	0.60
Dopaminergic	expressed_in	cell_type	0.55
Alpha-Synuclein	activates	pathway	0.55
Mitochondrial Function	causes	pathway	0.55
Microglia	causes	cell_type	0.55
Neuron	stabilizes	cell_type	0.55
Microglia	associated_with	cell_type	0.55
Protein Aggregation	causes	pathway	0.55
Alpha-Synuclein	causes	pathway	0.55
Microglia Activation	activates	pathway	0.55
Alpha-Synuclein	expressed_in	pathway	0.55
Lipid Metabolism	expressed_in	pathway	0.55
Neuron	expressed_in	cell_type	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
T Cell	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Autophagy	associated_with	pathway	0.55
Cholesterol	activates	pathway	0.55
Neuron	therapeutic_target	cell_type	0.55
Dopaminergic	therapeutic_target	cell_type	0.55
Microglia	activates	cell_type	0.55
Macrophage	activates	cell_type	0.55
T Cell	regulates	cell_type	0.55
Neuron	regulates	cell_type	0.55
Dopaminergic	regulates	cell_type	0.55
Neuron	causes	cell_type	0.55
Oxidative Stress	associated_with	pathway	0.55
Amyloid	contributes_to	pathway	0.55
Amyloid	activates	pathway	0.55
Epigenetic	associated_with	pathway	0.55
α-SYNUCLEIN	interacts_with	concept	0.50
TEMPORAL LOBE	activates	concept	0.50
NUCLEUS	regulates	concept	0.50
Temporal Lobe	associated_with	brain_region	0.50
HCRT	associated_with	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
Thalamus	associated_with	brain_region	0.50
Locus Coeruleus	associated_with	brain_region	0.50
Hypothalamus	associated_with	brain_region	0.50

Incoming (191)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	0.74
α-synuclein	activates	protein	0.70
ALZHEIMER'S DISEASE	regulates	disease	0.66
TAU	associated_with	protein	0.66
NEURODEGENERATION	therapeutic_target	gene	0.65
OVERVIEW	therapeutic_target	gene	0.65
MICROGLIA	activates	gene	0.65
GENES	expressed_in	gene	0.65
NEUROINFLAMMATION	expressed_in	gene	0.65
ASTROCYTE	expressed_in	gene	0.65
PARKINSON	expressed_in	gene	0.65
ALZHEIMER	expressed_in	gene	0.65
AND	expressed_in	gene	0.65
ALZHEIMER'S DISEASE	expressed_in	gene	0.65
PARKINSON'S DISEASE	expressed_in	gene	0.65
EPILEPSY	regulates	gene	0.65
MICROGLIA ACTIVATION	activates	gene	0.65
NEUROINFLAMMATION	activates	gene	0.65
ALZHEIMER	regulates	gene	0.65
DISEASE-ASSOCIATED MICROGLIA	activates	gene	0.65
ALZHEIMER'S DISEASE	regulates	gene	0.65
GPNMB	activates	gene	0.65
TAUOPATHY	associated_with	gene	0.65
AMYLOID	contributes_to	gene	0.65
TAU	contributes_to	gene	0.65
PINK1	associated_with	gene	0.65
APP	activates	gene	0.65
PTEN	activates	gene	0.65
AND	activates	gene	0.65
APP/PS1	activates	gene	0.65
AMYLOID	activates	gene	0.65
ANXIETY	associated_with	gene	0.65
ACHE	associated_with	gene	0.65
LRRK2	contributes_to	gene	0.65
SYNUCLEINOPATHY	associated_with	gene	0.65
OXIDATIVE STRESS	associated_with	gene	0.65
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.65
GDNF	associated_with	gene	0.65
P62	expressed_in	gene	0.65
PARKINSON'S DISEASE	causes	gene	0.65
PARKINSON	causes	gene	0.65
NEURODEGENERATIVE DISORDERS	causes	gene	0.65
GUT-BRAIN AXIS	causes	gene	0.65
INFLAMMATION	causes	gene	0.65
NEURODEGENERATION	causes	gene	0.65
ALPHA-SYNUCLEIN	causes	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.65
AGING	causes	gene	0.65
ALZHEIMER	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LEWY BODY in their description or question text

No additional research found