concept

AMYGDALA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYGDALA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

288Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	AMYGDALA
Key Genes/Proteins	AKT, ALZHEIMER, AMPK, AMYLOID, APP
Related Diseases	ACETYLCHOLINE, aging, Alzheimer'S Disease, ALZHEIMER'S DISEASE, ANXIETY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Amygdala

brain · 2721 words

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Pathway Diagram

graph TD
    AMYGDALA["AMYGDALA"]
    AMYGDALA -->|"regulates"| CORTEX["CORTEX"]
    AMYGDALA -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    AMYGDALA -->|"reduces"| FRONTAL["FRONTAL"]
    AMYGDALA -->|"activates"| ANXIETY["ANXIETY"]
    AMYGDALA -->|"activates"| NEURON["NEURON"]
    AMYGDALA -->|"activates"| NEURONS["NEURONS"]
    AMYGDALA -->|"activates"| TUMOR["TUMOR"]
    CRH["CRH"] -->|"expressed in"| AMYGDALA
    CRHR1["CRHR1"] -->|"expressed in"| AMYGDALA
    FKBP5["FKBP5"] -->|"expressed in"| AMYGDALA
    RAMP1["RAMP1"] -->|"expressed in"| AMYGDALA
    GENES["GENES"] -->|"expressed in"| AMYGDALA
    NR3C1["NR3C1"] -->|"expressed in"| AMYGDALA
    CALCA["CALCA"] -->|"expressed in"| AMYGDALA
    IL18["IL18"] -->|"expressed in"| AMYGDALA

Outgoing (108)

Target	Relation	Type	Str
CORTEX	regulates	brain_region	0.80
HIPPOCAMPUS	expressed_in	brain_region	0.80
CORTEX	expressed_in	brain_region	0.80
NEURONS	associated_with	cell_type	0.65
TDP-43	interacts_with	gene	0.65
FRONTAL	reduces	brain_region	0.65
AMYLOID	interacts_with	protein	0.65
STING	targets	gene	0.60
NEURON	inhibits	cell_type	0.60
TUMOR	activates	disease	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
ANXIETY	activates	disease	0.60
PREFRONTAL	regulates	brain_region	0.60
BDNF	biomarker_for	gene	0.60
CORTEX	contributes_to	brain_region	0.60
DEPRESSION	contributes_to	disease	0.60
CORTEX	causes	brain_region	0.60
FRONTAL	regulates	brain_region	0.60
DEPRESSION	implicated_in	disease	0.55
LOCUS COERULEUS	co_discussed	entity	0.50
EPILEPSY	co_discussed	entity	0.50
GRN	co_discussed	entity	0.50
BASAL GANGLIA	co_discussed	entity	0.50
BACE1	co_discussed	entity	0.50
GSK3B	co_discussed	entity	0.50
CORTEX	activates	brain_region	0.50
ANXIETY	regulates	disease	0.50
MITOCHONDRIA	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
P2RY12	co_discussed	entity	0.50
BRAINSTEM	co_discussed	entity	0.50
CHOLINERGIC	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
CIRCADIAN	co_discussed	entity	0.50
FTD	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
SEEDING	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
GABAergic	co_discussed	entity	0.50
GLUTAMATE	co_discussed	entity	0.50
GLUTAMATERGIC	co_discussed	entity	0.50
ENTORHINAL	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
DEPRESSION	co_discussed	entity	0.50

Incoming (180)

Source	Relation	Type	Str
ASTROCYTES	modulates	cell_type	0.85
PTSD	affects	disease	0.80
anxiety	affects	disease	0.80
depression	affects	disease	0.80
CRH	expressed_in	gene	0.70
APP	associated_with	gene	0.66
TEMPORAL LOBE	interacts_with	brain_region	0.65
APP	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
HCRT	expressed_in	gene	0.60
CR1	expressed_in	gene	0.60
DLG4	expressed_in	gene	0.60
schizophrenia	affects	disease	0.60
neuroinflammation	affects	disease	0.60
AR	expressed_in	gene	0.60
Alzheimer's disease	affects	disease	0.60
aging	affects	disease	0.60
dopamine signaling	active_in	pathway	0.60
unfolded protein response	active_in	pathway	0.60
SAPAP3	expressed_in	gene	0.60
synaptic plasticity	active_in	pathway	0.60
GABA	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.56
TNF	associated_with	gene	0.56
BDNF	associated_with	gene	0.56
CAMKII	expressed_in	gene	0.55
CRH	expressed_in	gene	0.55
CRHR1	expressed_in	gene	0.55
FKBP5	expressed_in	gene	0.55
RAMP1	expressed_in	gene	0.55
NR3C1	expressed_in	gene	0.55
CALCA	expressed_in	gene	0.55
IL18	expressed_in	gene	0.55
IL18BP	expressed_in	gene	0.55
BDNF	expressed_in	gene	0.55
DRD2	expressed_in	gene	0.55
Opioid	associated_with	disease	0.55
Addiction	associated_with	disease	0.55
IBA1	expressed_in	gene	0.55
OXIDATIVE STRESS	expressed_in	gene	0.55
AND	expressed_in	gene	0.55
TNF-Α	expressed_in	gene	0.55
EXERCISE	expressed_in	gene	0.55
AMPK	expressed_in	gene	0.55
NEURON	expressed_in	gene	0.55
RNA	expressed_in	gene	0.55
GABA	expressed_in	gene	0.55
AGING	expressed_in	gene	0.55
NEUROINFLAMMATION	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Age-dependent downregulation of KPNA2 creates limbic neuron-	0.452	neurodegeneration	What mechanisms drive TDP-43 pathology s

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AMYGDALA in their description or question text

No additional research found