concept

INSULIN SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

836Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

INSULIN SIGNALING is a concept in neurodegeneration research. Key relationships include: transports, co discussed, causes. Associated with NEURODEGENERATION. Connected to 14 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	INSULIN SIGNALING
Key Genes/Proteins	AD, AKT, AMPK, AMYLOID, APC, APP
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
Related Pathways	APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Brain Insulin Signaling Pathway

mechanism · 2316 words

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Pathway Diagram

graph TD
    INSULIN_SIGNALING["INSULIN SIGNALING"]
    INSULIN_SIGNALING -->|"interacts"| Cholesterol["Cholesterol"]
    INSULIN_SIGNALING -->|"interacts"| Glycolysis["Glycolysis"]
    INSULIN_SIGNALING -->|"interacts"| Mtor["Mtor"]
    INSULIN_SIGNALING -->|"interacts"| Synaptic_Plasticity["Synaptic Plasticity"]
    INSULIN_SIGNALING -->|"interacts"| Nf__b["Nf-Kappab"]
    IRS1["IRS1"] -->|"regulates"| INSULIN_SIGNALING
    PI3K_Akt_mTOR["PI3K-Akt-mTOR"] -->|"interacts"| INSULIN_SIGNALING
    PI3K_Akt_mTOR_pathway["PI3K-Akt/mTOR pathway"] -->|"interacts"| INSULIN_SIGNALING
    IGF_1["IGF-1"] -->|"regulates"| INSULIN_SIGNALING
    JUN["JUN"] -->|"activates"| INSULIN_SIGNALING
    MTOR["MTOR"] -->|"activates"| INSULIN_SIGNALING
    AKT["AKT"] -->|"activates"| INSULIN_SIGNALING
    GENES["GENES"] -->|"activates"| INSULIN_SIGNALING
    Obesity["Obesity"] -->|"activates"| INSULIN_SIGNALING
    Diabetes["Diabetes"] -->|"activates"| INSULIN_SIGNALING

Outgoing (179)

Target	Relation	Type	Str
Mitochondrial Dysfunction	regulates	process	0.90
Cognitive Function	regulates	phenotype	0.90
Insulin Resistance	involved_in	phenotype	0.90
Parkinson's Disease	involved_in	disease	0.90
Glucose Disposal	regulates	phenotype	0.90
Alzheimer's Disease	involved_in	disease	0.90
NEURODEGENERATION	protects_against	process	0.88
TAU	regulates	protein	0.85
neurons	active_in	cell_type	0.80
Insulin Resistance	causes	phenotype	0.80
neural stem cells	active_in	cell_type	0.80
Autophagy	regulates	process	0.80
Tau Hyperphosphorylation	inhibits	process	0.80
Retinal Ganglion Cell Neuroprotection	involved_in	mechanism	0.80
MTOR	upstream_of	gene	0.80
Retinal Ganglion Cell	modulates	cell_type	0.75
MICROGLIA	expresses	cell_type	0.70
TAU	activates	gene	0.70
TAU	disrupts	gene	0.70
NLRP3	transports	gene	0.70
MICROGLIA	targets	cell_type	0.70
PI3K/AKT/MTOR	causes	pathway	0.70
PSEN2	regulates	gene	0.70
TLR4	activates	gene	0.70
PSEN2	activates	gene	0.70
TAU	inhibits	gene	0.70
STING	inhibits	gene	0.70
blood-brain barrier	active_in	brain_region	0.70
TNF	activates	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
astrocytes	active_in	cell_type	0.70
ALZHEIMER'S DISEASE	treats	disease	0.65
APP	regulates	gene	0.65
NEURONS	activates	cell_type	0.65
INSULIN RESISTANCE	treats	phenotype	0.65
PICALM	mediates	gene	0.60
SRC	regulates	gene	0.60
MTOR	inhibits	gene	0.60
NEURON	expresses	cell_type	0.60
MAPK	expresses	gene	0.60
MAPK	associated_with	gene	0.60
MTOR	causes	gene	0.60
hippocampus	active_in	brain_region	0.60
endothelial cells	active_in	cell_type	0.60
NEURON	transports	cell_type	0.60
MTOR	activates	gene	0.60
MTOR	regulates	gene	0.60
OXIDATIVE STRESS	associated_with	pathway	0.60
STING	activates	gene	0.60
PARKINSON'S DISEASE	regulates	disease	0.60

Incoming (657)

Source	Relation	Type	Str
Als	activates	disease	1.00
PI3K	activates	gene	1.00
Inflammation	activates	disease	1.00
INSULIN RESISTANCE	activates	gene	1.00
Insulin Resistance	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
Aging	activates	disease	1.00
AKT	mediates	protein	0.95
GLP-1	associated_with	protein	0.95
AKT	component_of	protein	0.90
GLP-1R	activates	receptor	0.90
insulin receptor	activates	receptor	0.90
diabetes	involves	disease	0.90
AMPK	regulates	protein	0.90
MTOR	component_of	protein	0.90
Alzheimer's disease	involves	disease	0.90
AGING	activates	gene	0.90
AKT	activates	gene	0.90
GENES	activates	gene	0.90
MTOR	activates	gene	0.90
Aging	therapeutic_target	disease	0.90
Alzheimer	activates	disease	0.90
Glp-1 Receptor Agonists	associated_with	drug	0.87
neurons	active_in	cell_type	0.85
APOE4	participates_in	gene	0.85
resveratrol	activates	drug	0.85
astrocytes	active_in	cell_type	0.85
microglia	active_in	cell_type	0.85
PI3K	participates_in	gene	0.80
neurodegeneration	involves	disease	0.80
MTOR	inhibits	gene	0.80
OXIDATIVE STRESS	contributes_to	gene	0.80
ALZHEIMER'S DISEASE	activates	gene	0.80
Diabetes	activates	disease	0.80
Diabetes	associated_with	disease	0.80
ALZHEIMER	activates	gene	0.80
Alzheimer	associated_with	disease	0.80
APOPTOSIS	activates	gene	0.80
TAU	activates	gene	0.80
Obesity	activates	disease	0.80
AKT	regulates	gene	0.80
AMYLOID	activates	gene	0.80
ALZHEIMER	associated_with	gene	0.80
Neurodegeneration	associated_with	disease	0.80
Diabetes	therapeutic_target	disease	0.80
NEURODEGENERATION	associated_with	gene	0.80
INSULIN RESISTANCE	associated_with	gene	0.80
Cardiovascular	activates	disease	0.80
INSULIN RESISTANCE	therapeutic_target	gene	0.80
Insulin Resistance	associated_with	disease	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.585

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning INSULIN SIGNALING in their description or question text

No additional research found