concept

AMYLOID-Β

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID-Β: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

364Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	AMYLOID-Β
Key Genes/Proteins	APP, CLU, PSEN1
Related Diseases	Alzheimer Disease, Alzheimer's disease, Alzheimer's Disease, neurodegenerative diseases

Pathway Diagram

graph TD
    AMYLOID__["AMYLOID-Beta"]
    AMYLOID__ -->|"contributes to"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    AMYLOID__ -.biomarker for.-> Alzheimer_S_Disease["Alzheimer'S Disease"]
    AMYLOID__ -->|"causes"| Neurofibrillary_Tangles["Neurofibrillary Tangles"]
    AMYLOID__ -->|"modulates"| Astrocytes["Astrocytes"]
    AMYLOID__ -->|"involved_in"| Intracellular_Aggregation["Intracellular Aggregation"]
    LRP1["LRP1"] -->|"regulates"| AMYLOID__
    LRP1_targeted_Polymersomes["LRP1-targeted Polymersomes"] -->|"targets"| AMYLOID__
    Modified_Antibody["Modified Antibody"] -->|"targets"| AMYLOID__

Outgoing (73)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.95
ALZHEIMER'S DISEASE	contributes_to	entity	0.95
Inflammation	associated_with	process	0.95
Neurofibrillary Tangles	causes	biomarker	0.95
alzheimer_disease	biomarker_for	disease	0.95
Alzheimer's Disease	involved_in	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.95
Alzheimer'S Disease	biomarker_for	disease	0.95
Alzheimer Disease	associated_with	disease	0.95
Alzheimer Disease	biomarker_for	disease	0.95
ALZHEIMER	causes	disease	0.95
PANoptosis	activates	process	0.92
Microglia	activates	cell_type	0.90
Amyloid Plaques	associated_with	entity	0.90
Alzheimer's Disease	causes	disease	0.90
Astrocytes	modulates	cell_type	0.90
Alzheimer's disease	associated_with	disease	0.90
Alzheimer's disease	biomarker_for	disease	0.90
Alzheimer's Disease	involved_in	disease	0.90
ALZHEIMER'S DISEASE	biomarker_for	disease	0.90
Post-Stroke Cognitive Impairment	involved_in	disease	0.89
pathological seeds	associated_with	protein	0.85
tau	promotes	protein	0.85
Tau Phosphorylation	associated_with	process	0.85
Microglia	activates	cell_type	0.85
synaptopathy	causes	process	0.85
cognitive decline	drives	phenotype	0.85
Intracellular Aggregation	involved_in	process	0.85
Proteostasis dysfunction	contributes_to	process	0.85
Alzheimer'S Disease	causes	disease	0.85
plasma biomarkers	biomarker_for	process	0.85
Mitochondrial Stress	causes	process	0.85
synapse loss	causes	process	0.80
neurodegenerative diseases	implicated_in	disease	0.80
microglial_activation	activates	mechanism	0.80
amyloid-related imaging abnormalities	causes	phenotype	0.80
MICROGLIA	activates	cell_type	0.80
Alzheimer's Disease	causes	disease	0.80
Alzheimer's disease	causes	disease	0.80
synaptic dysfunction	causes	process	0.80
Alzheimer's disease	implicated_in	disease	0.80
apoptosis	activates	process	0.70
protein aggregates	causes	process	0.70
mitophagy	inhibits	process	0.70
Alzheimer's disease	associated_with	disease	0.70
Alzheimer's disease	causes	disease	0.70
Alzheimer's disease	causes	disease	0.70
Tau	mediates	protein	0.70
Tau	associated_with	protein	0.70
lipid droplet formation	activates	process	0.70

Incoming (291)

Source	Relation	Type	Str
LRP1-targeted Polymersomes	targets	drug	0.95
Modified Antibody	targets	drug	0.95
APP	associated_with	protein	0.95
Lecanemab	targets	drug	0.95
Donanemab	targets	drug	0.95
BACE1	associated_with	entity	0.95
Lecanemab	targets	drug	0.95
Donanemab	targets	drug	0.95
APP	associated_with	gene	0.95
APP	produces	gene	0.95
donanemab	binds_to	drug	0.95
Γ-SECRETASE	produces	enzyme	0.95
LRP1	regulates	entity	0.95
Modified Antibody	targets	drug	0.95
Lecanemab	targets	drug	0.92
Donanemab	targets	drug	0.92
Ceramide	contributes_to	compound	0.90
aducanumab	targets	drug	0.90
APOE	interacts_with	gene	0.90
TAU	interacts_with	protein	0.90
Presenilin Complex	associated_with	entity	0.90
Amyloid Precursor Protein	associated_with	protein	0.90
APOE ε2	inhibits	gene	0.90
PSEN1	associated_with	protein	0.90
APOE	associated_with	gene	0.90
MTOR	promotes	gene	0.90
apoE	interacts_with	protein	0.90
CLU	interacts_with	protein	0.90
PSEN1	upregulates	gene	0.90
APOE	associated_with	protein	0.85
GLP-1R	prevents	protein	0.85
TFEB	promotes	protein	0.85
amyloid hypothesis	associated_with	pathway	0.85
Hdac3 Inhibition	associated_with	mechanism	0.85
Aducanumab	targets	drug	0.85
PSEN1	upregulates	gene	0.85
PSEN2	upregulates	gene	0.85
Lysosomal Degradation	degrades	process	0.85
Mtor Inhibition	associated_with	mechanism	0.85
CYP46A1	regulates	gene	0.80
HMGCR	regulates	gene	0.80
VDAC1	interacts_with	gene	0.80
ABCA7	transports	gene	0.80
Alzheimer's Disease	causes	disease	0.80
CROCETIN	promotes clearance of	compound	0.80
Alzheimer's disease	biomarker_for	disease	0.70
PSEN1	regulates	gene	0.70
APOE	regulates	protein	0.70
APOE4	interacts_with	protein	0.70
APP	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed conflicting therapeutic approaches - enhancing DNA repair ve

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Related Research

Hypotheses and analyses mentioning AMYLOID-Β in their description or question text

No additional research found