gene

IL12B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL12B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

IL12B is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, inhibits. Associated with ALS, Als, Atherosclerosis. Connected to 53 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL12B
Aliases	Page for IL12B Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	Er Stress, Blood-Brain Barrier, Autophagy
Ensembl ID	ENSG00000167299
GeneCards	IL12B
Human Protein Atlas	IL12B
IL-12p70 formation	Pairs with IL-12p35
IL-23 formation	Pairs with IL-23p19
p40 homodimer	Acts as IL-12 antagonist
Cellular sources	Dendritic cells, macrophages, monocytes, microglia
Induction	By LPS, TNF-α, IFN-γ
Brain	Elevated in neuroinflammatory conditions
Associated Diseases	primary_Sjogren_disease
Interactions	AND, ATF4, Chemokine, CLDN5, CXCL1, CXCL2
KG Connections	87 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL12B Gene - Interleukin 12 Beta

gene · 695 words

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Pathway Diagram

graph TD
    IL12B["IL12B"]
    primary_Sjogren_disease{"primary_Sjogren_disease"}
    IL12B -->|"decreases risk"| primary_Sjogren_disease
    Ms{"Ms"}
    IL12B -->|"therapeutic target"| Ms
    Als{"Als"}
    IL12B -->|"therapeutic target"| Als
    IL12B -->|"activates"| Als
    Atherosclerosis{"Atherosclerosis"}
    IL12B -->|"expressed in"| Atherosclerosis
    IL12B -->|"expressed in"| Ms
    Tumor{"Tumor"}
    IL12B -->|"expressed in"| Tumor
    ALS{"ALS"}
    IL12B -->|"activates"| ALS
    XBP1["XBP1"]
    IL12B -->|"therapeutic target"| XBP1
    CXCL1["CXCL1"]
    IL12B -->|"inhibits"| CXCL1
    DDIT3["DDIT3"]
    IL12B -->|"therapeutic target"| DDIT3
    CLDN5["CLDN5"]
    IL12B -->|"inhibits"| CLDN5
    CXCL2["CXCL2"]
    CXCL2 -->|"inhibits"| IL12B
    IL6["IL6"]
    IL6 -->|"inhibits"| IL12B
    ATF4["ATF4"]
    ATF4 -->|"therapeutic target"| IL12B
    PPP1R15A["PPP1R15A"]
    PPP1R15A -->|"therapeutic target"| IL12B
    ATF4 -->|"activates"| IL12B
    CLDN5 -->|"inhibits"| IL12B
    DMSO["DMSO"]
    DMSO -->|"expressed in"| IL12B
    TNF["TNF"]
    TNF -->|"activates"| IL12B
    ZFP36L2["ZFP36L2"]
    ZFP36L2 -->|"expressed in"| IL12B
    ZFP36["ZFP36"]
    ZFP36 -->|"expressed in"| IL12B
    XBP1 -->|"activates"| IL12B
    HSPA5["HSPA5"]
    HSPA5 -->|"activates"| IL12B
    style IL12B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
Microglial Activation	associated_with	process	0.80
primary_Sjogren_disease	decreases_risk	disease	0.80
ALS	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Er Stress	inhibits	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
ITPR1	expressed_in	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
MAP1LC3B	expressed_in	gene	0.60
TIMP1	expressed_in	gene	0.60
CYTOKINES	inhibits	gene	0.60
AND	inhibits	gene	0.60
Endothelial	therapeutic_target	cell_type	0.60
Autophagy	expressed_in	pathway	0.60
AUTOPHAGY	expressed_in	gene	0.60
IL6	inhibits	gene	0.60
CXCL2	inhibits	gene	0.60
PPP1R15A	therapeutic_target	gene	0.60
IRE1	activates	gene	0.60
Chemokine	inhibits	protein	0.60
Cytokine	inhibits	protein	0.60
IL23A	activates	entity	0.60
RNA	activates	gene	0.60
OCLN	activates	entity	0.60
PERK	therapeutic_target	gene	0.60
IRE1	therapeutic_target	gene	0.60
IL6	activates	entity	0.60
DDIT3	therapeutic_target	gene	0.60
CLDN5	inhibits	gene	0.60
HSPA5	therapeutic_target	gene	0.60
OCLN	inhibits	gene	0.60
IL23A	inhibits	gene	0.60
HSPA5	activates	gene	0.60
XBP1	activates	gene	0.60
DDIT3	activates	gene	0.60
PERK	activates	gene	0.60
ATF4	activates	gene	0.60
PPP1R15A	activates	gene	0.60
ATF4	therapeutic_target	gene	0.60
GENES	expressed_in	gene	0.60
RNA	therapeutic_target	gene	0.60
Erk	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60
XBP1	therapeutic_target	gene	0.60
CXCL1	inhibits	gene	0.60

Incoming (32)

Source	Relation	Type	Str
DTG	upregulates	entity	0.90
Microglia-like cells	downregulates	cell_type	0.80
extracellular vesicles	upregulates	compound	0.75
IL6	inhibits	gene	0.60
ATF4	therapeutic_target	gene	0.60
PPP1R15A	therapeutic_target	gene	0.60
ATF4	activates	gene	0.60
CLDN5	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
IRE1	therapeutic_target	gene	0.60
PERK	therapeutic_target	gene	0.60
XBP1	therapeutic_target	gene	0.60
DDIT3	therapeutic_target	gene	0.60
HSPA5	therapeutic_target	gene	0.60
CXCL2	inhibits	gene	0.60
XBP1	activates	gene	0.60
HSPA5	activates	gene	0.60
IL23A	inhibits	gene	0.60
PERK	activates	gene	0.60
PPP1R15A	activates	gene	0.60
DDIT3	activates	gene	0.60
IRE1	activates	gene	0.60
CXCL1	inhibits	gene	0.60
DMSO	expressed_in	gene	0.60
ZFP36	expressed_in	gene	0.60
CLDN5	activates	entity	0.60
CXCL1	activates	entity	0.60
CXCL2	activates	entity	0.60
RNA	therapeutic_target	gene	0.60
TNF	activates	gene	0.60
ZFP36L2	expressed_in	gene	0.60
OCLN	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL12B in their description or question text

No additional research found