gene

TMEM173

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM173: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TMEM173 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 92 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TMEM173
Full Name	Stimulator of Interferon Genes (STING)
Chromosome	5q31.2
Protein Type	Receptor
Function	is a critical innate immune receptor that plays a central role in detecting cytosolic DNA and initiating type I interferon responses.
Molecular Weight	42 kDa
Amino Acids	379 aa
Pathways	NF-κB
UniProt ID	Q86WV1
NCBI Gene ID	340061
Ensembl ID	ENSG00000184515
OMIM	612374
GeneCards	TMEM173
Human Protein Atlas	TMEM173
Associated Diseases	Als, Carcinoma, Ms
Interactions	ALOX, AND, APOPTOSIS, ATG, AUTOPHAGY, CANCER
SciDEX Hypotheses	STING-Mediated NLRP3 Inflammasome Priming in ALS M
KG Connections	131 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TMEM173 — AlphaFold Q86WV1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TMEM173 (STING)

gene · 882 words

→

Pathway Diagram

graph TD
    TMEM173["TMEM173"]
    TMEM173 -->|"activates"| Cancer["Cancer"]
    TMEM173 -->|"activates"| Als["Als"]
    TMEM173 -->|"target for"| Inflammation["Inflammation"]
    TMEM173 -->|"activates"| Aging["Aging"]
    TMEM173 -->|"activates"| Ms["Ms"]
    TMEM173 -->|"activates"| Tumor["Tumor"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| TMEM173
    PER["PER"] -->|"activates"| TMEM173
    TFAM["TFAM"] -->|"activates"| TMEM173
    IRF3["IRF3"] -->|"activates"| TMEM173
    STING["STING"] -->|"activates"| TMEM173
    MTDNA["MTDNA"] -->|"activates"| TMEM173
    CGAS_STING["CGAS-STING"] -->|"interacts"| TMEM173
    IL6["IL6"] -->|"activates"| TMEM173
    JAK["JAK"] -->|"activates"| TMEM173
    TNF["TNF"] -->|"activates"| TMEM173

Outgoing (77)

Target	Relation	Type	Str
DNA Sensing Pathway	mediates	pathway	0.90
DNA Sensing Pathway	component_of	pathway	0.85
Inflammation	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Pancreatic Cancer	activates	disease	0.65
Infection	activates	disease	0.65
Tumor	activates	disease	0.65
Inflammation	activates	disease	0.65
ALS	activates	disease	0.65
NCOA4	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
LC3	associated_with	gene	0.60
STING	activates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
FERROPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Apoptosis	activates	pathway	0.60
GENES	activates	gene	0.60
BMAL1	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
Innate Immunity	activates	pathway	0.60
Oxidative Phosphorylation	activates	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Immune Response	activates	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
STING	associated_with	gene	0.60
Complement	associated_with	pathway	0.60
Ferroptosis	activates	pathway	0.60
Autophagy	activates	pathway	0.60
MTDNA	associated_with	gene	0.60
DNA	activates	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
ATM	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
STING1	regulates	gene	0.60
TNFAIP3	regulates	gene	0.60
RIPK3	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60

Incoming (54)

Source	Relation	Type	Str
MITOCHONDRIAL DNA	activates	gene	0.60
ALOX	associated_with	gene	0.60
ATG	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
STING	associated_with	gene	0.60
TFAM	activates	gene	0.60
IRF3	activates	gene	0.60
STING	activates	gene	0.60
ARNTL	activates	entity	0.60
ATM	activates	entity	0.60
BMAL1	activates	entity	0.60
CGAS	activates	entity	0.60
FANCD2	activates	entity	0.60
GPX4	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
NCOA4	activates	entity	0.60
POLG	activates	entity	0.60
SLC7A11	activates	entity	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
JAK	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
ATM	associated_with	gene	0.60
IL6	activates	gene	0.60
TNF	activates	gene	0.60
STAT1	activates	gene	0.60
STING1	activates	gene	0.60
PER	activates	gene	0.60
MTDNA	activates	gene	0.60
CGAS-STING	interacts_with	gene	0.60
ALOX	activates	gene	0.60
ATG	activates	gene	0.60
ROS	activates	gene	0.60
LC3	activates	gene	0.60
DNA	activates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia	0.380	Neuroinflammation	Immune atlas neuroinflammation analysis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TMEM173 in their description or question text

No additional research found