gene

TYMP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TYMP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

34Outgoing

11Incoming

0Experiments

0Debates

Summary

TYMP (Thymidine Phosphorylase) is essential for mitochondrial DNA maintenance and nucleotide metabolism. Mutations cause MNGIE, a severe mitochondrial disorder with neurogastrointestinal and neurological manifestations.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TYMP
Full Name	Thymidine Phosphorylase
Protein Type	Protein
Function	Thymidine phosphorylase (TYMP) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate.
Amino Acids	482 aa
UniProt ID	Search UniProt
GeneCards	TYMP
Human Protein Atlas	TYMP
Associated Diseases	Neuropathy
Interactions	IL1B, VEGFA
KG Connections	45 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TYMP — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TYMP Gene

gene · 2318 words

→

Pathway Diagram

graph TD
    TYMP["TYMP"]
    Ms{"Ms"}
    TYMP -->|"therapeutic target"| Ms
    TNF["TNF"]
    TYMP -->|"biomarker for"| TNF
    DISC1["DISC1"]
    TYMP -->|"biomarker for"| DISC1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    TYMP -->|"therapeutic target"| OXIDATIVE_STRESS
    PRDM1["PRDM1"]
    TYMP -->|"biomarker for"| PRDM1
    Oxidative_Stress(["Oxidative Stress"])
    TYMP -->|"therapeutic target"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    TYMP -->|"implicated in"| neurodegeneration
    style TYMP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Neuropathy	associated_with	disease	0.65
MITOCHONDRIAL DNA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
MPV17	expressed_in	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
multiple sclerosis	expressed_in	disease	0.60
RRM2B	associated_with	gene	0.60
TK2	associated_with	gene	0.60
SUCLA2	associated_with	gene	0.60
SUCLG1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
RNASEH1	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
MPV17	associated_with	gene	0.60
DGUOK	associated_with	gene	0.60
VEGFA	activates	gene	0.60
VEGFA	causes	gene	0.60
VEGFA	expressed_in	gene	0.60
endothelial cells	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
TNF	biomarker_for	gene	0.60
DISC1	biomarker_for	gene	0.60
PRDM1	biomarker_for	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
blood-brain barrier	participates_in	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
astrocytes	expressed_in	cell_type	0.55

Incoming (11)

Source	Relation	Type	Str
DGUOK	associated_with	gene	0.60
SUCLG1	associated_with	gene	0.60
TK2	associated_with	gene	0.60
IL1B	activates	gene	0.60
POLG2	associated_with	gene	0.60
SLC25A4	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
MTDNA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TYMP in their description or question text

No additional research found